Results 91 to 100 of about 2,084,616 (297)
Cardiac Sodium Channel Nav1.5 Mechanosensitivity is Inhibited by Ranolazine
, 2012 The cardiac action potential (AP) is initiated by the depolarizing inward sodium current (I(Na)). The pore-forming subunit of the cardiac sodium channel, Na(v)1.5, is the main ion channel that conducts I(Na) in cardiac cells.
Abriel, Hugues
core +1 more source
A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]
, 2013 TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars +14 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang +13 more
wiley +1 more source
Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy
, 2012 Sodium channel gene aberrations are associated with a wide range of seizure disorders, particularly Dravet syndrome. They usually consist of missense or truncating gene mutations or deletions.
Tschumi, Sibylle +6 more
core +1 more source
Knockdown of zebrafish Nav1.6 sodium channel impairs embryonic locomotor activities [PDF]
, 2009 Although multiple subtypes of sodium channels are expressed in most neurons, the specific contributions of the individual sodium channels remain to be studied.
陳曜鴻; Chen, Yau-hung; Huang, F. L.; Cheng, Y. C.; Wu, C. J.; Yang, C. N.; Tsay, H. J.
core +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Na1.7 and Na1.8: Role in the pathophysiology of pain
Molecular Pain, 2019 Chronic pain is a significant unmet medical problem. Current research regarding sodium channel function in pathological pain is advancing with the hope that it will enable the development of isoform-specific sodium channel blockers, a promising treatment
Shaila Hameed
doaj +1 more source
Marine Toxins That Target Voltage-gated Sodium Channels
Marine Drugs, 2006 : Eukaryotic, voltage-gated sodium (NaV) channels are large membrane proteins which underlie generation and propagation of rapid electrical signals in nerve, muscle and heart. Nine different NaV receptor sites, for natural ligands and/or drugs, have been
Robert J. French +3 more
doaj +1 more source
Kinetic model based on molecular mechanism for action potential [PDF]
, 2011 The Hodgkin-Huxley model for action potentials has been widely used but was not built on a microscopic description of the neuronal membrane. Through molecular dynamics simulations, the molecular mechanism of the channel currents is becoming clear ...
Lizhong Xu
core
Fabrication Routes for Ionic Conducting Fiber Strain Sensors
Advanced Engineering Materials, EarlyView.Ionic conducting fiber strain sensors (ICFSs) offer compliant, textile‐integrable sensing. Thus far, the commercialization of ICFSs has been constrained by fiber fabrication routes. This review provides a fabrication‐centric analysis of ICFSs correlating processing strategies with material properties and scalability.
Leo John Kershaw +3 more
wiley +1 more source