Results 111 to 120 of about 331,376 (161)
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Journal of Medicinal Chemistry, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Donald J, Kyle, Victor I, Ilyin
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Donald J, Kyle, Victor I, Ilyin
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Current Opinion in Nephrology and Hypertension, 1994
The highly selective amiloride-sensitive epithelial sodium channel is expressed in the distal part of the nephron, the distal colon, and the lung. It plays a critical role in the control of sodium balance, extracellular volume, blood pressure, and of fluid reabsorption in the lung. The primary structure of the rat epithelial sodium channel has recently
Rossier BC +3 more
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The highly selective amiloride-sensitive epithelial sodium channel is expressed in the distal part of the nephron, the distal colon, and the lung. It plays a critical role in the control of sodium balance, extracellular volume, blood pressure, and of fluid reabsorption in the lung. The primary structure of the rat epithelial sodium channel has recently
Rossier BC +3 more
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Amiloride and the sodium channel
Naunyn-Schmiedeberg's Archives of Pharmacology, 1974Amiloride and the sodium channel. The diuretic drugs amiloride and triamterene have been used as probes for sodium channels in the mucosal surface of isolated frog skin. Both substances interact competitively with sodium for the channel. Using 14C-amiloride measurements were made of the number of channels present in the mucosal surface under a variety ...
A W, Cuthbert, W K, Shum
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Cardiac Sodium Channel Diseases
Clinical Chemistry and Laboratory Medicine, 2003In the last few years, a very active line of research took place after the first identification of SCN5A mutations associated with an inherited form of cardiac arrhythmias and sudden death, the LQT3 variant of the long QT syndrome. Subsequently, two allelic diseases additional to LQT3 were shown to be due to mutations in the same gene, the Brugada ...
Napolitano,C, Rivolta, I, Priori, SG
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Introduction to Sodium Channels
2014Voltage-gated sodium channels (VGSCs) are present in many tissue types within the human body including both cardiac and neuronal tissues. Like other channels, VGSCs activate, deactivate, and inactivate in response to changes in membrane potential.
Colin H, Peters, Peter C, Ruben
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2017
Voltage-gated sodium channels (VGSC) are critical determinants of cellular electrical activity through the control of initiation and propagation of action potential. To ensure this role, these proteins are not consistently delivered to the plasma membrane but undergo drastic quality controls throughout various adaptive processes such as biosynthesis ...
Mercier, Aurélie +2 more
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Voltage-gated sodium channels (VGSC) are critical determinants of cellular electrical activity through the control of initiation and propagation of action potential. To ensure this role, these proteins are not consistently delivered to the plasma membrane but undergo drastic quality controls throughout various adaptive processes such as biosynthesis ...
Mercier, Aurélie +2 more
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2015
Human and mouse genetic studies have led to significant advances in our understanding of the role of voltage-gated sodium channels in pain pathways. In this chapter, we focus on Nav1.7, Nav1.8, Nav1.9 and Nav1.3 and describe the insights gained from the detailed analyses of global and conditional transgenic Nav knockout mice in terms of pain behaviour.
Abdella M, Habib +2 more
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Human and mouse genetic studies have led to significant advances in our understanding of the role of voltage-gated sodium channels in pain pathways. In this chapter, we focus on Nav1.7, Nav1.8, Nav1.9 and Nav1.3 and describe the insights gained from the detailed analyses of global and conditional transgenic Nav knockout mice in terms of pain behaviour.
Abdella M, Habib +2 more
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Neurology, 2007
Voltage-gated sodium (Na+) channels play a key role in membrane excitation in neurons. These channels have a critical role in the development and maintenance of several pain syndromes, including inflammatory pain, neuropathic pain, and central pain associated with spinal cord injury.1–4 The increasing understanding of the molecular organization ...
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Voltage-gated sodium (Na+) channels play a key role in membrane excitation in neurons. These channels have a critical role in the development and maintenance of several pain syndromes, including inflammatory pain, neuropathic pain, and central pain associated with spinal cord injury.1–4 The increasing understanding of the molecular organization ...
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Sodium channels and transporters in the myometrium
Current Opinion in Physiology, 2020In excitable cells such as neurons and cardiomyocytes, sodium influx across the plasma membrane contributes to the resting membrane potential, and sodium is the key ion for generating action potentials. In myometrial smooth muscle cells, however, the functions of sodium influx have not been fully elucidated.
Chinwendu Amazu +3 more
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Bacterial Sodium Channels: Models for Eukaryotic Sodium and Calcium Channels
2014Eukaryotic sodium and calcium channels are made up of four linked homologous but different transmembrane domains. Bacteria express sodium channels comprised of four identical subunits, each being analogous to a single homologous domain of their eukaryotic counterparts.
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