Results 121 to 130 of about 331,376 (161)

Epithelial Sodium Channel: A Ligand-Gated Channel?

Nephron Physiology, 2004
The epithelial sodium channel (ENaC) is a key component of the transepithelial Na⁺ transport. In epithelia, it is responsible for the maintenance of Na⁺ balance (which in turn controls extracellular fluid volume and arterial blood pressure) and the regulation of airway surface fluid. While the regulation of
Jean-Daniel, Horisberger, Ahmed, Chraïbi   +1 more
openaire   +2 more sources

Sodium channel mutations and arrhythmias

Nature Reviews Cardiology, 2009
Since the identification of the first SCN5A mutation associated with long QT syndrome in 1995, several mutations in this gene for the alpha subunit of the cardiac sodium channel have been identified in a heterogeneous subset of cardiac rhythm syndromes, including Brugada syndrome, progressive cardiac conduction defect, sick sinus node syndrome, atrial ...
Ruan Y, Liu N, PRIORI, SILVIA GIULIANA
openaire   +2 more sources

Gating of sodium and potassium channels

The Journal of Membrane Biology, 1985
Voltage-dependent conductances play a fundamental role in the generation and propagation of the action potential. Hodgkin and Huxley (1952c) made a complete description of the membrane currents underlying the generation of the impulse. Their description introduced the concepts of separate pathways for sodium and potassium (today called Na and K ...
openaire   +2 more sources

Epithelial Sodium Channels (ENaCs)

2015
Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
openaire   +1 more source

Gating in Sodium Channels of Nerve

Annual Review of Physiology, 1976
During the period 1937-1952 the study of electrical excitability mechanisms in axons matured from discoveries of membrane impedance changes to a complete kinetic description of ionic permeability changes in the squid giant axon (35). There followed a period of relative stagnation while the results on squid were rechecked and new voltage clamp methods ...
openaire   +2 more sources

Open-state structure and pore gating mechanism of the cardiac sodium channel

Cell, 2021
Daohua Jiang, Richard Banh, Tamer M Gamal El-Din   +2 more
exaly  

A Sodium Channel Model

Annals of the New York Academy of Sciences, 1993
C, Sato, G, Matsumoto
openaire   +2 more sources

Structure of the Cardiac Sodium Channel

Cell, 2020
Daohua Jiang, Hui Shi, Lige Tonggu
exaly  

Sodium Channels

2020
Jannis Körner, Angelika Lampert
openaire   +1 more source

Inactivation of the sodium channel. I. Sodium current experiments.

Journal of General Physiology, 1977
FRANCISCO Bezanilla, Bezanilla F, Armstrong C M   +2 more
exaly