Results 21 to 30 of about 2,084,616 (297)
Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy
Frontiers in Neuroscience, 2023 Developmental and epileptic encephalopathies (DEEs) are severe seizure disorders with inadequate treatment options. Gain- or loss-of-function mutations of neuronal ion channel genes, including potassium channels and voltage-gated sodium channels, are ...
Sophie F. Hill +6 more
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Channels, 2023 One of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion ...
J. David Spafford
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Frontiers in Neurology, 2021 Genetic epilepsy occurs as a result of mutations in either a single gene or an interplay of different genes. These mutations have been detected in ion channel and non-ion channel genes. A noteworthy class of ion channel genes are the voltage gated sodium
Ibitayo Abigail Ademuwagun +8 more
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Sodium channels and pain [PDF]
Proceedings of the National Academy of Sciences, 1999 Although it is well established that hyperexcitability and/or increased baseline sensitivity of primary sensory neurons can lead to abnormal burst activity associated with pain, the underlying molecular mechanisms are not fully understood. Early studies demonstrated that, after injury to their axons, neurons can display changes in excitability ...
S G, Waxman +3 more
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Excitability constraints on voltage-gated sodium channels. [PDF]
PLoS Computational Biology, 2007 We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
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Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]
, 1992 The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
Quasthoff, Stefan +3 more
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The R563Q Mutation of the Beta Subunit of the Epithelial Sodium Channel: Prevalence and Effect [PDF]
, 2009 Hypertension is a major worldwide predictor of morbidity and mortality. The search for genes that contribute to blood pressure is ongoing. The epithelial sodium channel genes were implicated when the beta subunit (SCNN1B, gene ID 6338) was found to have ...
Jones, Dr Erika Sherad Wilshire +1 more
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Molecular Pain, 2011 Background Voltage-gated sodium channels play key roles in acute and chronic pain processing. The molecular, biophysical, and pharmacological properties of sodium channel currents have been extensively studied for peripheral nociceptors while the ...
Smith Paula L +5 more
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Theoretical implication of liganding reactions in axonal sodium channel gating [PDF]
, 1980 Dorogi PL, Neumann E. Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International. 1980;2:45-51.Mathematical simulation models for measured permeability properties of axonal Na+ channels point to the ...
Dorogi, Peter L., Neumann, Eberhard
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Altered sodium channel-protein associations in critical illness myopathy
Skeletal Muscle, 2012 Background During the acute phase of critical illness myopathy (CIM) there is inexcitability of skeletal muscle. In a rat model of CIM, muscle inexcitability is due to inactivation of sodium channels.
Kraner Susan D +4 more
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