Results 21 to 30 of about 331,376 (161)

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. [PDF]

PLoS ONE, 2016
Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine
Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W Mason, Philip T Sager, Esther Pueyo, David G Strauss   +6 more
doaj   +1 more source

Sodium Current Measurements in HEK293 Cells

Bio-Protocol, 2013
This protocol is used to measure sodium currents from heterologously transfected cells lines, such as HEK293 cells. Standard whole cell patch clamp technique is used to assess ion channel function. This protocol has been used to study cardiac type Nav1.5
Helena Riuró, Anna Tarradas, Elisabet Selga, Ramon Brugada, Fabiana Scornik, Guillermo Pérez   +5 more
doaj   +1 more source

Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model.

PLoS Computational Biology, 2021
State-dependent sodium channel blockers are often prescribed to treat cardiac arrhythmias, but many sodium channel blockers are known to have pro-arrhythmic side effects.
Steffen S Docken, Colleen E Clancy, Timothy J Lewis   +2 more
doaj   +1 more source

On Conduction in a Bacterial Sodium Channel

PLoS Computational Biology, 2012
Voltage-gated Na⁺-channels are transmembrane proteins that are responsible for the fast depolarizing phase of the action potential in nerve and muscular cells. Selective permeability of Na⁺ over Ca²⁺ or K⁺ ions is essential for the biological function of Na⁺-channels.
Simone Furini, Carmen Domene
openaire   +5 more sources

Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms

Cell Reports, 2016
Twelve sodium-activated potassium channel (KCNT1, Slack) genetic mutants have been identified from severe early-onset epilepsy patients. The changes in biophysical properties of these mutants and the underlying mechanisms causing disease remain elusive ...
Qiong-Yao Tang, Fei-Fei Zhang, Jie Xu, Ran Wang, Jian Chen, Diomedes E. Logothetis, Zhe Zhang   +6 more
doaj   +1 more source

Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.

PLoS ONE, 2011
BackgroundDuchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is associated with severe cardiac complications including cardiomyopathy and cardiac arrhythmias.
Xaver Koenig, Sandra Dysek, Stefanie Kimbacher, Agnes K Mike, Rene Cervenka, Peter Lukacs, Katrin Nagl, Xuan B Dang, Hannes Todt, Reginald E Bittner, Karlheinz Hilber   +10 more
doaj   +1 more source

New Theoretical Model of Nerve Conduction in Unmyelinated Nerves

Frontiers in Physiology, 2017
Nerve conduction in unmyelinated fibers has long been described based on the equivalent circuit model and cable theory. However, without the change in ionic concentration gradient across the membrane, there would be no generation or propagation of the ...
Tetsuya Akaishi, Tetsuya Akaishi
doaj   +1 more source

A Heart Failure-Associated SCN5A Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel

Frontiers in Physiology, 2021
Nav1.5, encoded by the gene SCN5A, is the predominant voltage-gated sodium channel expressed in the heart. It initiates the cardiac action potential and thus is crucial for normal heart rhythm and function.
Yang Zheng, Yang Zheng, Xiaoping Wan, Dandan Yang, Angelina Ramirez-Navarro, Haiyan Liu, Ji-Dong Fu, Isabelle Deschênes   +7 more
doaj   +1 more source

Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease

Reviews in Cardiovascular Medicine
Myocardial infarction (MI)-related arrhythmias are an essential risk factor in sudden cardiac death. Aberrant cardiac the cardiac voltage-gated sodium channel (Nav1.5) is important in the development of ventricular arrhythmias after an MI.
Xiao-Lu Zhang, Tian-Peng Wei, Fan Yang, Huan-Huan Liu, Ling-Ling Qian, Ru-Xing Wang   +5 more
doaj   +1 more source

Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti

Insects, 2016
Pyrethroid insecticides are widely used to control insect pests and human disease vectors. Voltage-gated sodium channels are the primary targets of pyrethroid insecticides.
Yuzhe Du, Yoshiko Nomura, Boris S. Zhorov, Ke Dong   +3 more
doaj   +1 more source