Results 11 to 20 of about 331,376 (161)
Channels, 2023 One of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion ...
J. David Spafford
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Frontiers in Neurology, 2021 Genetic epilepsy occurs as a result of mutations in either a single gene or an interplay of different genes. These mutations have been detected in ion channel and non-ion channel genes. A noteworthy class of ion channel genes are the voltage gated sodium
Ibitayo Abigail Ademuwagun +8 more
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Excitability constraints on voltage-gated sodium channels. [PDF]
PLoS Computational Biology, 2007 We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
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Molecular Pain, 2011 Background Voltage-gated sodium channels play key roles in acute and chronic pain processing. The molecular, biophysical, and pharmacological properties of sodium channel currents have been extensively studied for peripheral nociceptors while the ...
Smith Paula L +5 more
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Altered sodium channel-protein associations in critical illness myopathy
Skeletal Muscle, 2012 Background During the acute phase of critical illness myopathy (CIM) there is inexcitability of skeletal muscle. In a rat model of CIM, muscle inexcitability is due to inactivation of sodium channels.
Kraner Susan D +4 more
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 2005 We have explored the permeation and blockage of ions in sodium channels, relating the channel structure to function using electrostatic profiles and Brownian dynamics simulations. The model used resembles the KcsA potassium channel with an added external vestibule and a shorter selectivity filter.
Vora, Taira, Corry, Ben, Chung, Shin-Ho
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BMC Neuroscience, 2010 Background Antillatoxin (ATX) is a structurally unique lipopeptide produced by the marine cyanobacterium Lyngbya majuscula. ATX activates voltage-gated sodium channel α-subunits at an undefined recognition site and stimulates sodium influx in neurons ...
Gerwick William H +2 more
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Frontiers in Pharmacology, 2011 Chronic and neuropathic pain constitute significant health problems affecting millions of individuals each year. Pain sensations typically originate in sensory neurons of the peripheral nervous system (PNS) which relay information to the central nervous
Jonathan W. Theile, Theodore R Cummins
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Cannabidiol interactions with voltage-gated sodium channels
eLife, 2020 Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two
Lily Goodyer Sait +5 more
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Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. [PDF]
PLoS Genetics, 2008 In many mammalian neurons, dense clusters of ion channels at the axonal initial segment and nodes of Ranvier underlie action potential generation and rapid conduction.
Alexis S Hill +7 more
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