Results 11 to 20 of about 2,084,616 (297)

Molecular basis of sodium channel inactivation [PDF]

Nature Communications
Voltage-gated sodium channels initiate action potentials and control electrical signaling throughout the animal kingdom. Fast inactivation is an essential auto-inhibitory mechanism and requisite component of sodium channel physiology.
Yichen Liu, Jason D. Galpin, Christopher A. Ahern, Francisco Bezanilla   +3 more
doaj   +2 more sources

Sodium Channel mRNA Binding Proteins [PDF]

JACC: Basic to Translational Science
Barry London, MD, PhD
doaj   +2 more sources

How Sodium and Calcium Ions Pass Through Batrachotoxin-Bound Sodium Channel [PDF]

Toxins
Steroidal sodium channel agonist batrachotoxin (BTX), one of the most potent animal toxins, dramatically increases calcium permeation and alters other channel characteristics.
Boris S. Zhorov
doaj   +2 more sources

The Cardiac Sodium Channel Safety Profile of Cenobamate at Therapeutic Concentrations: In Vitro Analyses [PDF]

Clinical and Translational Science
The US Food and Drug Administration (FDA) issued a Drug Safety Communication for the antiseizure drug lamotrigine (Lamictal), warning of the risk of QRS prolongation and cardiac arrhythmias.
William J. Crumb Jr, Susan M. Melnick, Kelli J. Glenn   +2 more
doaj   +2 more sources

Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

Drug Design, Development and Therapy, 2017
Marawan Ahmed,1 Horia Jalily Hasani,1,* Aravindhan Ganesan,1,* Michael Houghton,2–4 Khaled Barakat1–3 1Faculty of Pharmacy and Pharmaceutical Sciences, 2Li Ka Shing Institute of Virology, 3Li Ka Shing Applied Virology Institute, 4Department ...
Ahmed M, Jalily Hasani H, Ganesan A, Houghton M, Barakat K   +4 more
doaj   +1 more source

Drug binding sites on Nat1.8 sodium channels [PDF]

, 2008
The voltage-gated sodium channel, Nav 1.8, is known to play an important role in pain signalling. In this thesis, the functional properties and drug binding sites of wild type and mutant Nav 1.8 sodium channel currents were studied in mammalian sensory ...
Browne, Liam Edward
core   +6 more sources

Neuroplastic alteration of TTX-resistant sodium channel with visceral pain and morphine-induced hyperalgesia

Journal of Pain Research, 2012
Jinghong Chen,1,2,4 Ze-hui Gong,4 Hao Yan,2 Zhijun Qiao,3 Bo-yi Qin41Department of Internal Medicine, Neuroscience Program, The University of Texas Medical Branch, Galveston, TX, USA; 2The Divisions of Pharmacy, Pharmacology core lab, MD Anderson Cancer ...
Chen J, Gong Z, Yan H, Qiao Z, Qin B
doaj   +1 more source

Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

BMC Neurology, 2021
Background Many antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect the response to ASMs due to altering the effect of ASMs on blocking sodium channels.
Chih-Hsiang Lin, Chen-Jui Ho, Yan-Ting Lu, Meng-Han Tsai   +3 more
doaj   +1 more source

Sodium channels [PDF]

Brain and Neuroscience Advances, 2018
In 2000, with the completion of the human genome project, nine related channels were found to comprise the complete voltage-gated sodium gene family and they were renamed Na V 1.1–Na V 1.9.
Wood, JN, Iseppon, F
openaire   +3 more sources

Highly Sensitive and Selective Sodium Ion Sensor Based on Silicon Nanowire Dual Gate Field-Effect Transistor

Sensors, 2021
In this study, a highly sensitive and selective sodium ion sensor consisting of a dual-gate (DG) structured silicon nanowire (SiNW) field-effect transistor (FET) as the transducer and a sodium-selective membrane extended gate (EG) as the sensing unit was
Seong-Kun Cho, Won-Ju Cho
doaj   +1 more source