Results 1 to 10 of about 61,667 (115)

Voltage-gated sodium channel, Nav 1.8, regulates calcium dynamics in the dorsal root ganglion induced by cold nociceptive stimulus. [PDF]

PLoS ONE
Nociceptive pain responses are mediated by neurons in the dorsal root ganglion. Certain voltage-gated sodium channels, such as Nav 1.8, are necessary for action potential firing and sensing pain.
Moushumi Rani Dey, Baolin Li, John Heddleston, Eitaro Aihara   +3 more
doaj   +2 more sources

Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins [PDF]

Toxins
µ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and putative leads for analgesic development.
Kirsten L. McMahon, Irina Vetter, Christina I. Schroeder   +2 more
doaj   +2 more sources

Voltage-Gated Sodium Channel Dysfunction in Epilepsy: Zebrafish Models for Therapeutics [PDF]

Biomedicines
Voltage-gated sodium channels (VGSCs) play pivotal roles in cellular function, particularly in the regulation of electrical signaling. Structural defects in these channels cause deleterious effects in a myriad of cell types, leading to various diseases ...
Angela Gyamfi, Priyadharshini Manikandan, William A. Cisneros, Theodore R. Cummins, James A. Marrs   +4 more
doaj   +2 more sources

Structural mechanism of voltage-gated sodium channel slow inactivation [PDF]

Nature Communications
Voltage-gated sodium (NaV) channels mediate a plethora of electrical activities. NaV channels govern cellular excitability in response to depolarizing stimuli.
Huiwen Chen, Zhanyi Xia, Jie Dong, Bo Huang, Jiangtao Zhang, Feng Zhou, Rui Yan, Yiqiang Shi, Jianke Gong, Juquan Jiang, Zhuo Huang, Daohua Jiang   +11 more
doaj   +2 more sources

Genetic epilepsy with febrile seizures plus – an overview [PDF]

Romanian Journal of Neurology, 2021
Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu, Eugenia Roza, Daniel Mihai Teleanu, Raluca Ioana Teleanu   +3 more
doaj   +1 more source

In-Silico Computational Analysis Of [6-(2, 3-Dichlorophenyl)-1, 2, 4-Triazine-3, 5-Diamine] Metal Complexes on Voltage Gated Sodium Channel and Dihydrofolate Reductase Enzyme

Pakistan Journal of Pharmaceutical Sciences, 2020
Epilepsy is the disease associated with seizures and convulsions. Various antiepileptic drugs have been used widely to treat these disorders. Lamotrigine [6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine] shows certain adverse effects at small doses, to
Saima Najm, Humaira Naureen, Kishwar Sultana, Fareeha Sattar, Sara Daud, Najm-ul-Hassan, Muhammad Mubbashir Khan   +6 more
doaj   +3 more sources

Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels

Frontiers in Physiology, 2023
Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the treatment of epilepsy.
Carol J. Milligan, Lyndsey L. Anderson, Lyndsey L. Anderson, Lyndsey L. Anderson, Iain S. McGregor, Iain S. McGregor, Iain S. McGregor, Jonathon C. Arnold, Jonathon C. Arnold, Jonathon C. Arnold, Steven Petrou, Steven Petrou   +11 more
doaj   +1 more source

Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels

Marine Drugs, 2023
Marine toxins have potent actions on diverse sodium ion channels regulated by transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic acetylcholine receptor channels).
James R. Groome
doaj   +1 more source

Voltage-Gated Sodium Channel Dysfunctions in Neurological Disorders

Life, 2023
The pore-forming subunits (α subunits) of voltage-gated sodium channels (VGSC) are encoded in humans by a family of nine highly conserved genes. Among them, SCN1A, SCN2A, SCN3A, and SCN8A are primarily expressed in the central nervous system. The encoded
Raffaella Barbieri, Mario Nizzari, Ilaria Zanardi, Michael Pusch, Paola Gavazzo   +4 more
doaj   +1 more source

Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites

Frontiers in Pharmacology, 2022
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri, Tamer M. Gamal El-Din   +1 more
doaj   +1 more source