Results 11 to 20 of about 66,157 (301)

Calmodulin Interactions with Voltage-Gated Sodium Channels [PDF]

International Journal of Molecular Sciences, 2021
Calmodulin (CaM) is a small protein that acts as a ubiquitous signal transducer and regulates neuronal plasticity, muscle contraction, and immune response. It interacts with ion channels and plays regulatory roles in cellular electrophysiology. CaM modulates the voltage-gated sodium channel gating process, alters sodium current density, and regulates ...
Xin Wu, Liang Hong
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Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels

Frontiers in Physiology, 2023
Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the treatment of epilepsy.
Carol J. Milligan, Lyndsey L. Anderson, Lyndsey L. Anderson, Lyndsey L. Anderson, Iain S. McGregor, Iain S. McGregor, Iain S. McGregor, Jonathon C. Arnold, Jonathon C. Arnold, Jonathon C. Arnold, Steven Petrou, Steven Petrou   +11 more
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Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels

Marine Drugs, 2023
Marine toxins have potent actions on diverse sodium ion channels regulated by transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic acetylcholine receptor channels).
James R. Groome
doaj   +1 more source

Nomenclature of Voltage-Gated Sodium Channels [PDF]

Neuron, 2000
Voltage-gated Ca2+ channels mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression. They are members of a gene superfamily of transmembrane ion channel proteins that includes voltage-gated K+ and Na+ channels.
Goldin, Alan L., Barchi, Robert L., Caldwell, John H., Hofmann, Franz, Howe, James R., Hunter, John C., Kallen, Roland G., Mandel, Gail, Meisler, Miriam H., Netter, Yoheved Berwald, Noda, Masahara, Tamkun, Michael M., Waxman, Steven G., Wood, John N., Catterall, William A.   +14 more
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Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites

Frontiers in Pharmacology, 2022
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri, Tamer M. Gamal El-Din   +1 more
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The crystal structure of a voltage-gated sodium channel [PDF]

Nature, 2011
Voltage-gated sodium (Na(V)) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is unknown. Here we report the crystal structure of a voltage-gated Na(+) channel from Arcobacter butzleri (
Payandeh, Jian, Scheuer, Todd, Zheng, Ning, Catterall, William A.   +3 more
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Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]

, 2013
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E., Hall, Benjamin A., Wallace, Bonnie A., Claire E. Naylor, Christopher W. M. Kay, Paul G. Decaen, Clapham, David, Hall, B.A., Wallace, B. A., DeCaen, P.G., Naylor, Claire E., Benjamin A. Hall, B. A. Wallace, Bagneris, Claire, Kay, C.W.M., DeCaen, Paul, David E. Clapham, Kay, Christopher W. M.   +17 more
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Voltage-Gated Sodium Channels in Neocortical Pyramidal Neurons Display Cole-Moore Activation Kinetics

Frontiers in Cellular Neuroscience, 2018
Exploring the properties of action potentials is a crucial step toward a better understanding of the computational properties of single neurons and neural networks. The voltage-gated sodium channel is a key player in action potential generation.
Mara Almog, Tal Barkai, Angelika Lampert, Alon Korngreen, Alon Korngreen   +4 more
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Molecular mechanisms of the coupling of gating to voltage sensing in transmembrane proteins [PDF]

, 2014
Voltage gated potassium ion (Kv) channels regulate action potentials of the nervous system by responding to changes in transmembrane voltage, enabling K+ transport across the membrane to restore cells to their resting potential.
Starek, Greg
core   +1 more source

Inhibition by Pregnenolone Sulphate, a Metabolite of the Neurosteroid Pregnenolone, of Voltage-Gated Sodium Channels Expressed in Xenopus Oocytes

Journal of Pharmacological Sciences, 2012
Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Nav) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Nav,
Takafumi Horishita, Susumu Ueno, Nobuyuki Yanagihara, Yuka Sudo, Yasuhito Uezono, Dan Okura, Takeyoshi Sata   +6 more
doaj   +1 more source