Results 11 to 20 of about 2,526,088 (292)
Cannabidiol interactions with voltage-gated sodium channels [PDF]
eLife, 2020 Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two
Lily Goodyer Sait +5 more
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Excitability constraints on voltage-gated sodium channels. [PDF]
PLoS Computational Biology, 2007 We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
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Ubiquitylation of Voltage-Gated Sodium Channels
, 2014 Ion channel proteins are regulated by different types of posttranslational modifications. The focus of this review is the regulation of voltage-gated sodium channels (Navs) upon their ubiquitylation. The amiloride-sensitive epithelial sodium channel (ENaC) was the first ion channel shown to be regulated upon ubiquitylation.
Laedermann, Cédric J +2 more
openaire +5 more sources
Drug binding sites on Nat1.8 sodium channels [PDF]
, 2008 The voltage-gated sodium channel, Nav 1.8, is known to play an important role in pain signalling. In this thesis, the functional properties and drug binding sites of wild type and mutant Nav 1.8 sodium channel currents were studied in mammalian sensory ...
Browne, Liam Edward
core +6 more sources
Fenestropathy of Voltage-Gated Sodium Channels [PDF]
Frontiers in Pharmacology, 2022 Voltage-gated sodium channels (Nav) are responsible for the initiation and propagation of action potentials in excitable cells. From pain to heartbeat, these integral membrane proteins are the ignition stations for every sensation and action in human bodies.
Tamer M. Gamal El-Din +2 more
openaire +3 more sources
Nomenclature of Voltage-Gated Sodium Channels [PDF]
Neuron, 2000 Voltage-gated Ca2+ channels mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression. They are members of a gene superfamily of transmembrane ion channel proteins that includes voltage-gated K+ and Na+ channels.
Goldin, Alan L. +14 more
openaire +2 more sources
The crystal structure of a voltage-gated sodium channel [PDF]
Nature, 2011 Voltage-gated sodium (Na(V)) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is unknown. Here we report the crystal structure of a voltage-gated Na(+) channel from Arcobacter butzleri (
Payandeh, Jian +3 more
openaire +2 more sources
Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]
, 2013 Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E. +17 more
core +2 more sources
Frontiers in Cellular Neuroscience, 2018 Exploring the properties of action potentials is a crucial step toward a better understanding of the computational properties of single neurons and neural networks. The voltage-gated sodium channel is a key player in action potential generation.
Mara Almog +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2012 Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Nav) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Nav,
Takafumi Horishita +6 more
doaj +1 more source