Results 31 to 40 of about 66,157 (301)

Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene [PDF]

, 2004
Dynamic changes in synaptic connectivity and strength, which occur during both embryonic development and learning, have the tendency to destabilize neural circuits.
Baines, Richard A.; id_orcid, Baines, Richard A., Mee, Christopher J., Moffat, Kevin G., Pym, Edward C G, Pym, Edward C. G.   +5 more
core   +1 more source

Functional correlates of clinical phenotype and severity in recurrent SCN2A variants

Communications Biology, 2022
A comprehensive biophysical analysis of disease-associated mutations in the voltage-gated sodium channel gene, SCN2A, suggests that dynamic action potential clamp may be a better predictor than voltage clamp of how these mutations alter neuronal ...
Géza Berecki, Katherine B. Howell, Jacqueline Heighway, Nelson Olivier, Jill Rodda, Isabella Overmars, Danique R. M. Vlaskamp, Tyson L. Ware, Simone Ardern-Holmes, Gaetan Lesca, Michael Alber, Pierangelo Veggiotti, Ingrid E. Scheffer, Samuel F. Berkovic, Markus Wolff, Steven Petrou   +15 more
doaj   +1 more source

Pumilio binds para mRNA and requires nanos and brat to regulate sodium current in drosophila motoneurons [PDF]

, 2008
Homeostatic regulation of ionic currents is of paramount importance during periods of synaptic growth or remodeling. Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of sodium current (INa) and excitability in ...
Moffat, K G, Weston, Andrew J., Baines, Richard A., Gerber, Andre P., Baines, R A, Muraro, Nara I., Luschnig, Stefan, Gerber, A P, Baines, Richard A.; id_orcid, Weston, A J, Moffat, Kevin G., Muraro, N I, Luschnig, S   +12 more
core   +1 more source

Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]

, 1992
The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
Quasthoff, Stefan, Mitrović, N., Strupp, Michael, Grafe, Peter   +3 more
core   +1 more source

Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease

Reviews in Cardiovascular Medicine
Myocardial infarction (MI)-related arrhythmias are an essential risk factor in sudden cardiac death. Aberrant cardiac the cardiac voltage-gated sodium channel (Nav1.5) is important in the development of ventricular arrhythmias after an MI.
Xiao-Lu Zhang, Tian-Peng Wei, Fan Yang, Huan-Huan Liu, Ling-Ling Qian, Ru-Xing Wang   +5 more
doaj   +1 more source

Voltage-gated sodium channels dysfunction in depression: the hypothesis

Psychiatry and Behavioral Sciences, 2016
Voltage-gated sodium (Na+) channels (VGSCs) are responsible for action potential initiation and propagation in most electrically excitable cells which are implicated in a wide range physiological functions including neuronal signalling, muscle ...
Osman Ozdemir
doaj   +1 more source

A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm.

PLoS Computational Biology, 2007
The activity of trans-membrane proteins such as ion channels is the essence of neuronal transmission. The currently most accurate method for determining ion channel kinetic mechanisms is single-channel recording and analysis.
Meron Gurkiewicz, Alon Korngreen
doaj   +1 more source

Determining the structure of the bacterial voltage-gated sodium channel NaChBac embedded in liposomes by cryo electron tomography and subtomogram averaging

Scientific Reports, 2023
Voltage-gated sodium channels shape action potentials that propagate signals along cells. When the membrane potential reaches a certain threshold, the channels open and allow sodium ions to flow through the membrane depolarizing it, followed by the ...
Shih-Ying Scott Chang, Patricia M. Dijkman, Simon A. Wiessing, Misha Kudryashev   +3 more
doaj   +1 more source

Voltage-gated sodium channels in cancers

Biomarker Research
AbstractVoltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate classic action potentials, showing potential as a promising pharmacological target for cancer ...
Hengrui Liu, Jieling Weng, Christopher L.-H. Huang, Antony P. Jackson   +3 more
openaire   +5 more sources

Voltage-Gated Sodium Channel expression and cancer [PDF]

, 2011
Deep insight on Voltage-Gated Sodium Channel expression and ...
Wang, Z
core   +1 more source