Results 21 to 30 of about 2,526,088 (292)
Voltage‐gated Sodium Channels in Epilepsy [PDF]
Epilepsia, 2002 Summary: Animal experiments, and particularly functional investigations on human chronically epileptic tissue as well as genetic studies in epilepsy patients and their families strongly suggest that some forms of epilepsy may share a pathogenetic mechanism: an alteration of voltage‐gated sodium channels. This review summarizes recent data on changes of
openaire +2 more sources
Toxins, 2016 The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez +5 more
doaj +1 more source
Frontiers in Physiology, 2015 Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH +1 more
doaj +1 more source
Structural Advances in Voltage-Gated Sodium Channels
Frontiers in Pharmacology, 2022 Voltage-gated sodium (NaV) channels are responsible for the rapid rising-phase of action potentials in excitable cells. Over 1,000 mutations in NaV channels are associated with human diseases including epilepsy, periodic paralysis, arrhythmias and pain disorders.
Daohua Jiang +5 more
openaire +3 more sources
Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel
Nature Communications, 2022 NaX is an atypical member of the voltage-gated sodium channel family that may contribute to Na+ homeostasis. Here, the authors describe the structural and functional attributes of the human NaX channel to reveal new insights into its physiology.
Cameron L. Noland +11 more
doaj +1 more source
Molecular mechanisms of the coupling of gating to voltage sensing in transmembrane proteins [PDF]
, 2014 Voltage gated potassium ion (Kv) channels regulate action potentials of the nervous system by responding to changes in transmembrane voltage, enabling K+ transport across the membrane to restore cells to their resting potential.
Starek, Greg
core +1 more source
Calmodulin Interactions with Voltage-Gated Sodium Channels [PDF]
International Journal of Molecular Sciences, 2021 Calmodulin (CaM) is a small protein that acts as a ubiquitous signal transducer and regulates neuronal plasticity, muscle contraction, and immune response. It interacts with ion channels and plays regulatory roles in cellular electrophysiology. CaM modulates the voltage-gated sodium channel gating process, alters sodium current density, and regulates ...
Xin Wu, Liang Hong
openaire +2 more sources
Can the Thermodynamic Hodgkin-Huxley Model of Voltage-Dependent Conductance Extrapolate for Temperature? [PDF]
, 2014 Hodgkin and Huxley (H-H) fitted their model of voltage-dependent conductances to experimental data using empirical functions of voltage. The thermodynamic H-H model of voltage dependent conductances is more physically plausible, as it constrains and ...
Michael D. Forrest +2 more
core +1 more source
Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. [PDF]
PLoS Genetics, 2008 In many mammalian neurons, dense clusters of ion channels at the axonal initial segment and nodes of Ranvier underlie action potential generation and rapid conduction.
Alexis S Hill +7 more
doaj +1 more source
Sodium channel inactivation kinetics of rat sensory and motor nerve fibres and their modulation by glutathione [PDF]
, 1993 Na+ channel currents of rat motor and sensory nerve fibres were studied with the patch-clamp technique on enzymatically demyelinated axons. Differences between motor and sensory fibres in multi-channel inactivation kinetics and the gating of late single ...
Quasthoff, Stefan +2 more
core +1 more source