Excitability constraints on voltage-gated sodium channels. [PDF]
PLoS Computational Biology, 2007 We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
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Fenestropathy of Voltage-Gated Sodium Channels [PDF]
Frontiers in Pharmacology, 2022 Voltage-gated sodium channels (Nav) are responsible for the initiation and propagation of action potentials in excitable cells. From pain to heartbeat, these integral membrane proteins are the ignition stations for every sensation and action in human ...
Tamer M. Gamal El-Din +2 more
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Voltage-gated sodium channels in cancers [PDF]
Biomarker ResearchVoltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate ...
Hengrui Liu +3 more
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Cannabidiol interactions with voltage-gated sodium channels [PDF]
eLife, 2020 Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two
Lily Goodyer Sait +5 more
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Structural Advances in Voltage-Gated Sodium Channels [PDF]
Frontiers in Pharmacology, 2022 Voltage-gated sodium (NaV) channels are responsible for the rapid rising-phase of action potentials in excitable cells. Over 1,000 mutations in NaV channels are associated with human diseases including epilepsy, periodic paralysis, arrhythmias and pain ...
Daohua Jiang +5 more
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Calmodulin Interactions with Voltage-Gated Sodium Channels. [PDF]
Int J Mol Sci, 2021 Calmodulin (CaM) is a small protein that acts as a ubiquitous signal transducer and regulates neuronal plasticity, muscle contraction, and immune response. It interacts with ion channels and plays regulatory roles in cellular electrophysiology. CaM modulates the voltage-gated sodium channel gating process, alters sodium current density, and regulates ...
Wu X, Hong L.
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Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels [PDF]
Marine Drugs, 2023 Marine toxins have potent actions on diverse sodium ion channels regulated by transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic acetylcholine receptor channels).
James R. Groome
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Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels [PDF]
Frontiers in Physiology, 2023 Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the treatment of epilepsy.
Carol J. Milligan +11 more
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Voltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions [PDF]
Neural Regeneration ResearchVoltage-gated sodium channels are essential ionic-conductance pathways in the nervous system, which play an irreplaceable role in modulating neuronal excitability and signal transduction.
Ni Li +5 more
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Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy [PDF]
Neurobiology of DiseaseSummary: Guanine nucleotide-binding protein Gβγ subunits are ubiquitous signaling molecules that interact with numerous effector proteins in neurons, including voltage-gated sodium, calcium, and potassium channels.
Nicholas Denomme +11 more
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