Fenestropathy of Voltage-Gated Sodium Channels [PDF]
Frontiers in Pharmacology, 2022 Voltage-gated sodium channels (Nav) are responsible for the initiation and propagation of action potentials in excitable cells. From pain to heartbeat, these integral membrane proteins are the ignition stations for every sensation and action in human ...
Tamer M. Gamal El-Din +2 more
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Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels [PDF]
Marine Drugs, 2023 Marine toxins have potent actions on diverse sodium ion channels regulated by transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic acetylcholine receptor channels).
James R. Groome
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Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites [PDF]
Frontiers in Pharmacology, 2022 Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri +1 more
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Structural Advances in Voltage-Gated Sodium Channels [PDF]
Frontiers in Pharmacology, 2022 Voltage-gated sodium (NaV) channels are responsible for the rapid rising-phase of action potentials in excitable cells. Over 1,000 mutations in NaV channels are associated with human diseases including epilepsy, periodic paralysis, arrhythmias and pain ...
Daohua Jiang +5 more
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Differential lipid dependence of the function of bacterial sodium channels. [PDF]
PLoS ONE, 2013 The lipid bilayer is important for maintaining the integrity of cellular compartments and plays a vital role in providing the hydrophobic and charged interactions necessary for membrane protein structure, conformational flexibility and function.
Nazzareno D'Avanzo +5 more
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Voltage-gated sodium channels in cancers [PDF]
Biomarker ResearchVoltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate ...
Hengrui Liu +3 more
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Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels [PDF]
Frontiers in Physiology, 2023 Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the treatment of epilepsy.
Carol J. Milligan +11 more
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Excitability constraints on voltage-gated sodium channels. [PDF]
PLoS Computational Biology, 2007 We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
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Sodium channels and mammalian sensory mechanotransduction [PDF]
Molecular Pain, 2012 Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin +7 more
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Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
Circulation Research, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Christopher A Ahern, Dennis A Dougherty
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