Results 11 to 20 of about 62,302 (192)

Voltage-gated sodium channels gene expression in Burning Mouth Syndrome: a case-control study

Brazilian Oral Research, 2023
Burning mouth syndrome (BMS) is a condition characterized by painful symptoms of the oral mucosa, despite the absence of any clinical signs. Its etiology is unknown, and there is still no effective treatment to date.
Carina DOMANESCHI, Vanessa Juliana Gomes CARVALHO, Bruno Munhoz MAROTTA, Norberto Nobuo SUGAYA, Fábio Daumas NUNES, Camila de Barros GALLO   +5 more
doaj   +2 more sources

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels [PDF]

Frontiers in Physiology, 2015
Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH, Hugues eAbriel   +1 more
doaj   +2 more sources

Inhibition of Voltage-Gated Sodium Channels by Animal Toxins [PDF]

Structural Dynamics
Voltage-gated sodium channels (NaVs) play important roles in propagating action potentials and their structure and function can be modulated by a variety of factors, including animal toxins.
Shane Gonen
doaj   +2 more sources

Voltage-gated sodium channels in taste bud cells [PDF]

BMC Neuroscience, 2009
Background Taste bud cells transmit information regarding the contents of food from taste receptors embedded in apical microvilli to gustatory nerve fibers innervating basolateral membranes.
Williams Mark E, Kalabat Dalia, Laita Bianca, Echeverri Fernando, Lu Min, Gao Na, Hevezi Peter, Zlotnik Albert, Moyer Bryan D   +8 more
doaj   +2 more sources

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres [PDF]

Frontiers in Pharmacology, 2015
Voltage-gated sodium channels are known to play a pivotal role in perception and transmission of pain sensations. Gain-of-function mutations in the genes encoding the peripheral neuronal sodium channels, hNav1.7-1.9, cause human painful diseases.
Roberta eCarbonara, Alessia eCarocci, Julien eRoussel, Giuseppe eCrescenzo, Canio eBuonavoglia, Carlo eFranchini, Giovanni eLentini, Diana eConte Camerino, Jean-François eDesaphy   +8 more
doaj   +2 more sources

Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites

Frontiers in Pharmacology, 2022
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri, Tamer M. Gamal El-Din   +1 more
doaj   +1 more source

Unmasking of Brugada syndrome by lamotrigine in a patient with pre-existing epilepsy: A case report with review of the literature

Frontiers in Cardiovascular Medicine, 2022
Brugada syndrome is an inherited cardiac channelopathy arising from mutations in voltage-gated cardiac sodium channels. Idiopathic epilepsy portrays a coalescent underlying pathophysiological mechanism pertaining to the premature excitation of neuronal ...
Hafiz Omer, Hafiz Omer, Mohamed H. Omer, Abdulmohsen R. Alyousef, Ali M. Alzammam, Omar Ahmad, Haitham A. Alanazi, Haitham A. Alanazi, Haitham A. Alanazi   +8 more
doaj   +1 more source

Nomenclature of Voltage-Gated Sodium Channels [PDF]

Neuron, 2000
Voltage-gated Ca2+ channels mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression. They are members of a gene superfamily of transmembrane ion channel proteins that includes voltage-gated K+ and Na+ channels.
Goldin, Alan L., Barchi, Robert L., Caldwell, John H., Hofmann, Franz, Howe, James R., Hunter, John C., Kallen, Roland G., Mandel, Gail, Meisler, Miriam H., Netter, Yoheved Berwald, Noda, Masahara, Tamkun, Michael M., Waxman, Steven G., Wood, John N., Catterall, William A.   +14 more
openaire   +2 more sources

The crystal structure of a voltage-gated sodium channel [PDF]

Nature, 2011
Voltage-gated sodium (Na(V)) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is unknown. Here we report the crystal structure of a voltage-gated Na(+) channel from Arcobacter butzleri (
Payandeh, Jian, Scheuer, Todd, Zheng, Ning, Catterall, William A.   +3 more
openaire   +2 more sources

Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]

, 2013
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E., Hall, Benjamin A., Wallace, Bonnie A., Claire E. Naylor, Christopher W. M. Kay, Paul G. Decaen, Clapham, David, Hall, B.A., Wallace, B. A., DeCaen, P.G., Naylor, Claire E., Benjamin A. Hall, B. A. Wallace, Bagneris, Claire, Kay, C.W.M., DeCaen, Paul, David E. Clapham, Kay, Christopher W. M.   +17 more
core   +1 more source