Results 1 to 10 of about 49,773 (253)

Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. [PDF]

PLoS ONE, 2016
Fever can increase the susceptibility to supraventricular and ventricular arrhythmias, in which sodium channel dysfunction has been implicated. Whether fever influences the efficacy of sodium channel blocking drugs is unknown.
Ibrahim El-Battrawy, Siegfried Lang, Zhihan Zhao, Ibrahim Akin, Gökhan Yücel, Sophie Meister, Bence Patocskai, Michael Behnes, Boris Rudic, Erol Tülümen, Volker Liebe, Malte Tiburcy, Jennifer Dworacek, Wolfram-Hubertus Zimmermann, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou   +17 more
doaj   +1 more source

Dihydropyridine Calcium Channel Blocker Therapy and Risk of CKD Progression in Type 2 Diabetes Treated With Renin Angiotensin System Inhibitors and SGLT2 Inhibitors: A Real-World Retrospective Cohort Study

Kidney Medicine
Rationale & Objective: Optimal antihypertensive therapy with renoprotective effects is essential to slow diabetic kidney disease progression. We evaluated the impact of dihydropyridine calcium channel blockers on kidney outcomes in patients with type
Timna Agur, Tali Steinmetz, Shira Goldman, Boris Zingerman, Dana Bielopolski, Eviatar Nesher, Ittai Fattal, Eshcar Meisel, Benaya Rozen-Zvi   +8 more
doaj   +1 more source

Anticonvulsant-induced downbeat nystagmus in epilepsy

Epilepsy and Behavior Case Reports, 2015
We report data from two patients who developed reversible downbeat nystagmus (DBN) while using AEDs within the therapeutic range. All previous reported cases of epilepsy with drug-induced DBN related to toxic levels of AEDs were summarized, and DBN was ...
Dongyan Wu, Roland D. Thijs
doaj   +1 more source

Synthesis and Evaluation of Novel α-Aminoamides Containing an Indole Moiety for the Treatment of Neuropathic Pain

Molecules, 2016
The α-aminoamide family of sodium ion channel blockers have exhibited analgesic effects on neuropathic pain. Here, a series of novel α-aminoamides containing an indole ring were designed and synthesized.
Haotian Li, Shiyong Fan, Jingchao Cheng, Ping Zhang, Bohua Zhong, Weiguo Shi   +5 more
doaj   +1 more source

Use of Ion-Channel Modulating Agents to Study Cyanobacterial Na⁺ - K⁺ Fluxes

Biological Procedures Online, 2004
Here we describe an experimental design aimed to investigate changes in total cellular levels of Na+ and K+ ions in cultures of freshwater filamentous cyanobacteria. Ion concentrations were measured in whole cells by flame photometry. Cellular Na+ levels
Pomati Francesco, Burns Brendan P., Neilan Brett A.   +2 more
doaj   +1 more source

Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation

eLife, 2019
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor.
Seungkyu Lee, Sooyeon Jo, Sébastien Talbot, Han-Xiong Bear Zhang, Masakazu Kotoda, Nick A Andrews, Michelino Puopolo, Pin W Liu, Thomas Jacquemont, Maud Pascal, Laurel M Heckman, Aakanksha Jain, Jinbo Lee, Clifford J Woolf, Bruce P Bean   +14 more
doaj   +1 more source

Gastroesophageal reflux disease and esophagitis associated with the use of drugs: the modern state of the problem [PDF]

Терапевтический архив, 2019
From the standpoint of evidence - based medicine, the ability of various drugs to induce the development of gastroesophageal reflux disease and esophagitis is considered.
A M Osadchuk, I L Davydkin, T A Gricenko, M A Osadchuk   +3 more
doaj   +1 more source

Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications

Clinical and Translational Science, 2022
Lamotrigine, approved for use as an antiseizure medication as well as the treatment of bipolar disorder, inhibits sodium channels in the brain to reduce repetitive neuronal firing and pathological release of glutamate.
Lindsey Ingleby‐Talecki, Sven C. vanDijkman, Sean P. Oosterholt, Oscar Della Pasqua, Christina Winter, Marianne Cunnington, Linda Rebar, Sergio Forero‐Schwanhaeuser, Vickas Patel, James A. Cooper, Anthony Bahinski, Khuram W. Chaudhary   +11 more
doaj   +1 more source

Pyridoxine‐responsive KCNQ2 epileptic encephalopathy: Additional cases and literature review

Molecular Genetics & Genomic Medicine, 2022
Background Typical patients with KCNQ2 (OMIM# 602235) epileptic encephalopathy present early neonatal‐onset intractable seizures with a burst suppression EEG pattern and severe developmental delay or regression, and those patients always fail first‐line ...
Jun Chen, Qiuji Tao, Lijuan Fan, Yajun Shen, Jinfeng Liu, Huan Luo, Zuozhen Yang, Mengmeng Liang, Jing Gan   +8 more
doaj   +1 more source

Clinical outcomes and immune benefits of anti-epileptic drug therapy in HIV/AIDS

BMC Neurology, 2010
Background Anti-epileptic drugs (AEDs) are frequently prescribed to persons with HIV/AIDS receiving combination antiretroviral therapy (cART) although the extent of AED use and their interactions with cART are uncertain.
Krentz Hartmut B, Siemieniuk Reed A, Vivithanaporn Pornpun, Lee Kathy, Maingat Ferdinand, Gill M John, Power Christopher   +6 more
doaj   +1 more source