Results 11 to 20 of about 49,773 (253)
Sodium Channel Blockers for Vestibular Paroxysmia in Children [PDF]
Audiology ResearchBackground/Objectives: As vestibular paroxysmia (VP) has recently been described in children, with an incidence of up to 4% of vertigo, and a promising therapeutic response to sodium-channel-blocking drugs has also been reported, the aim of this paper is
Pierre Reynard +5 more
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Cannabidiol combined with GABAergic drugs but not with sodium channel blockers prevents the development of drug-resistance seizures in a preclinical model [PDF]
Frontiers in PharmacologyDrug resistance affects 30% of patients with epilepsy. Cannabidiol (CBD) decreases the expression of drug-resistant seizures in specific syndromes. However, it is unknown if CBD prevents the development of drug-resistant condition in epilepsy.
Monserrat Fuentes-Mejia +5 more
doaj +2 more sources
Familial SCN1A‐Related Epilepsy in Palestinian Siblings: Challenges of Genetic Testing in Resource‐Limited Settings: A Case Report [PDF]
Clinical Case ReportsSCN1A‐related epilepsy may present in siblings with febrile and afebrile seizures. In resource‐limited settings, diagnosis relies heavily on clinical recognition and established criteria.
Anwar Abu Hetta +5 more
doaj +2 more sources
Sodium channel blockers for cystic fibrosis. [PDF]
Cochrane Database Syst Rev, 2014 People with cystic fibrosis (CF) have increased transport of the salt, sodium across their airway lining. Over-absorption of sodium results in the dehydration of the liquid that lines the airway surface and is a primary defect in people with CF.To determine whether the topical administration of drugs that block sodium transport improves the respiratory
Burrows EF, Southern KW, Noone PG.
europepmc +6 more sources
Magnesium in Aconitine‐Induced Electrical Storm—Mechanism Yes, Mandate No [PDF]
Annals of Noninvasive ElectrocardiologyAconitine poisoning produces lethal ventricular arrhythmias through persistent activation of cardiac sodium channels. We critically comment on a recent case report describing 28 biphasic shocks for aconitine‐induced electrical storm, addressing three ...
Zhong‐Qun Zhan, Hai‐Jun Xu
doaj +2 more sources
Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers
Фармакокинетика и Фармакодинамика, 2022 This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a range of sodium channel blockers. Among voltage-gated sodium channels, the Nav1.5 isoform is the
G. V. Mokrov
doaj +1 more source
Brain Sciences, 2022 Approximately 30% of epileptic patients develop Drug-Resistant Epilepsy. Based on evidence that shows a loss of efficacy in some sodium channel blocker antiseizure drugs in epilepsy, we focus our study on assessing the anticonvulsant efficacy of ...
Cecilia Zavala-Tecuapetla +3 more
doaj +1 more source
Sodium channel blockers for neuroprotection in multiple sclerosis. [PDF]
Cochrane Database Syst Rev, 2015 Multiple sclerosis (MS) is an autoimmune, inflammatory, demyelinating disease of the central nervous system (CNS), which can occur in many parts of the CNS and result in a wide range of symptoms including sensory impairment, fatigue, walking or balance problems, visual impairment, vertigo and cognitive disabilities.
Yang C, Hao Z, Zhang L, Zeng L, Wen J.
europepmc +3 more sources
Cardiac Sodium Channel Blockade Due to Antiepileptic Drug Combination
European Journal of Case Reports in Internal Medicine, 2021 Drugs that inhibit voltage-dependent sodium channels are commonly used to treat epilepsy. Old and novel antiepileptic drugs are used either as monotherapy or in combination to control epilepsy.
Ossama Maadarani +8 more
doaj +1 more source