Neonatal Episodic Laryngospasm Treated with Sodium Channel Blockers [PDF]
Pediatric Neurology Briefs, 2010 Three male neonates with episodic laryngospasms responsive to sodium channel blockers are reported by researchers at centres in Lyon, Paris and Rennes, France.
J Gordon Millichap
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Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes [PDF]
Frontiers in Pharmacology, 2011 Chronic and neuropathic pain constitute significant health problems affecting millions of individuals each year. Pain sensations typically originate in sensory neurons of the peripheral nervous system (PNS) which relay information to the central nervous
Jonathan W. Theile, Theodore R Cummins
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Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade [PDF]
Drug Design, Development and Therapy, 2017 Marawan Ahmed,1 Horia Jalily Hasani,1,* Aravindhan Ganesan,1,* Michael Houghton,2–4 Khaled Barakat1–3 1Faculty of Pharmacy and Pharmaceutical Sciences, 2Li Ka Shing Institute of Virology, 3Li Ka Shing Applied Virology Institute, 4Department ...
Ahmed M +4 more
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Sodium Channel Blockers Modulate Abnormal Activity of Regenerating Nociceptive Corneal Nerves After Surgical Lesion. [PDF]
Invest Ophthalmol Vis Sci, 2021 [Purpose]: To test the effect of different sodium channel blockers on the electrical activity of corneal nociceptors in intact and surgically injured corneas.[Methods]: In anesthetized guinea pigs, a 4-mm diameter corneal flap was performed in one eye at
Luna C +6 more
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PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers. [PDF]
J Am Coll Cardiol, 2016 BackgroundAntiarrhythmic drugs are widely used to treat patients with atrial fibrillation (AF), but the mechanisms conveying their variable effectiveness are not known.
Syeda F +14 more
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PRRT2-positive self-limited infantile epilepsy: Initial seizure characteristics and response to sodium channel blockers. [PDF]
Epilepsia Open, 2023 Objective Self‐limited infantile epilepsy (SeLIE) has distinctive clinical features, and the PRRT2 gene is known to be a considerable genetic cause.
Lee J, Kim YO, Lim BC, Lee J.
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Substituted pyridines as sodium channel blockers: patent highlight. [PDF]
ACS Med Chem Lett, 2012 Blass B.
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PLoS Computational Biology, 2021 State-dependent sodium channel blockers are often prescribed to treat cardiac arrhythmias, but many sodium channel blockers are known to have pro-arrhythmic side effects.
Steffen S Docken +2 more
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Locating the route of entry and binding sites of benzocaine and phenytoin in a bacterial voltage gated sodium channel. [PDF]
PLoS Computational Biology, 2014 Sodium channel blockers are used to control electrical excitability in cells as a treatment for epileptic seizures and cardiac arrhythmia, and to provide short term control of pain.
Lewis J Martin, Ben Corry
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Pharmaceuticals, 2023 Ischemia–reperfusion injury (IRI) is a common phenomenon that develops both from natural causes and during major operations. Many intracellular processes mediated by calcium ions are involved in the development of IRI. Currently, chemical calcium channel
Elena Iurova +8 more
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