Results 31 to 40 of about 49,773 (253)

Antiarrhythmic drug usage and prostate cancer: a population-based cohort study

Asian Journal of Andrology, 2018
Even though the relationship between antiarrhythmic drug usage and subsequent prostate cancer (PCa) risk has recently been highlighted, relevant findings in the previous literature are still inconsistent.
Li-Ting Kao, Chung-Chien Huang, Herng-Ching Lin, Chao-Yuan Huang   +3 more
doaj   +1 more source

Malignant Purkinje ectopy induced by sodium channel blockers

Heart Rhythm, 2022
Sodium channel blocker (SCB) infusion is used to unmask the electrocardiographic pattern of Brugada syndrome. The test may also induce premature ventricular complexes (PVCs) in individuals without Brugada pattern, the clinical relevance of which is little known.The purpose of this study was to describe the prevalence of short-coupled (Sc) PVCs induced ...
Escande, William, Gourraud, Jean-Baptiste, Haissaguerre, Michel, Gandjbakhch, Estelle, Lavergne, Thomas, Martins, Raphaël, Cheniti, Ghassen, Krisai, Philipp, Hermida, Jean Sylvain, Maury, Philippe, Merino, Jose-Louis, Pasquié, Jean Luc, Combes, Nicolas, Surget, Elodie, Duchâteau, Josselin, Pambrun, Thomas, Derval, Nicolas, Hocini, Meleze, Jaïs, Pierre, Postema, Pieter, Nademanee, Koonlawee, Vigmond, Ed, Bernus, Olivier, Sacher, Frédéric, Probst, Vincent   +24 more
openaire   +3 more sources

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. [PDF]

PLoS ONE, 2016
Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine
Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W Mason, Philip T Sager, Esther Pueyo, David G Strauss   +6 more
doaj   +1 more source

Na1.7 and Na1.8: Role in the pathophysiology of pain

Molecular Pain, 2019
Chronic pain is a significant unmet medical problem. Current research regarding sodium channel function in pathological pain is advancing with the hope that it will enable the development of isoform-specific sodium channel blockers, a promising treatment
Shaila Hameed
doaj   +1 more source

The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats [PDF]

Acute and Critical Care, 2018
Background Flecainide acetate is a drug used primarily for cardiac arrhythmia. Some studies also imply that flecainide acetate has the potential to regulate inflammatory-immune responses; however, its mechanism of action is contended.
Shi Young Chung, Jinyoung Kim, Hong Bum Bae, Tran Duc Tin, Wan Ju, Sang Hyun Kwak   +5 more
doaj   +1 more source

Efficacy and Safety of Lacosamide in Adolescents with Lennox-Gastaut Syndrome [PDF]

Annals of Child Neurology, 2020
Purpose We aimed to assess the efficacy and safety of lacosamide in Korean adolescents with Lennox-Gastaut syndrome (LGS), especially in those who concomitantly used other sodium channel blockers (SCBs).
Han Som Choi, Se Hee Kim, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim   +4 more
doaj   +1 more source

Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels [PDF]

Pesticide Biochemistry and Physiology, 2010
Sodium channel blocker insecticides (SCBIs) are a relatively new class of insecticides, with a mechanism of action different from those of other classes of insecticides that target voltage-gated sodium channels. These compounds have no effect at hyperpolarized membrane potentials, but cause a voltage-dependent, nearly irreversible block as the membrane
Kristopher S, Silver, Weizhong, Song, Yoshiko, Nomura, Vincent L, Salgado, Ke, Dong   +4 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source