Electrical plasticity and cardioprotection in myocardial ischemia--role of selective sodium channel blockers. [PDF]
Clin Cardiol, 2013 The concept of electrical protection of the ischemic myocardium is in constant evolution and has recently been supported by experimental and clinical studies.
Madonna R, Cevik C, Nasser M.
europepmc +2 more sources
Management of untreatable ventricular arrhythmias during pharmacologic challenges with sodium channel blockers for suspected Brugada syndrome [PDF]
, 2017 Pharmacologic challenge with sodium channel blockers is part of the diagnostic workout in patients with suspected Brugada syndrome. The test is overall considered safe but both ajmaline and flecainide detain well known pro-arrhythmic properties. Moreover,
Carlo Napolitano +23 more
core +1 more source
Na1.7 and Na1.8: Role in the pathophysiology of pain
Molecular Pain, 2019 Chronic pain is a significant unmet medical problem. Current research regarding sodium channel function in pathological pain is advancing with the hope that it will enable the development of isoform-specific sodium channel blockers, a promising treatment
Shaila Hameed
doaj +1 more source
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. [PDF]
PLoS ONE, 2016 Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine
Jose Vicente +6 more
doaj +1 more source
Efficacy and Safety of Lacosamide in Adolescents with Lennox-Gastaut Syndrome [PDF]
Annals of Child Neurology, 2020 Purpose We aimed to assess the efficacy and safety of lacosamide in Korean adolescents with Lennox-Gastaut syndrome (LGS), especially in those who concomitantly used other sodium channel blockers (SCBs).
Han Som Choi +4 more
doaj +1 more source
Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. [PDF]
PLoS ONE, 2016 Fever can increase the susceptibility to supraventricular and ventricular arrhythmias, in which sodium channel dysfunction has been implicated. Whether fever influences the efficacy of sodium channel blocking drugs is unknown.
Ibrahim El-Battrawy +17 more
doaj +1 more source
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers [PDF]
, 2007 A simple and convenient procedure for the preparation of beta-proline like derivatives in their racemic and optically active forms has been reported.
SCILIMATI A +8 more
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Kidney MedicineRationale & Objective: Optimal antihypertensive therapy with renoprotective effects is essential to slow diabetic kidney disease progression. We evaluated the impact of dihydropyridine calcium channel blockers on kidney outcomes in patients with type
Timna Agur +8 more
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Anticonvulsant-induced downbeat nystagmus in epilepsy
Epilepsy and Behavior Case Reports, 2015 We report data from two patients who developed reversible downbeat nystagmus (DBN) while using AEDs within the therapeutic range. All previous reported cases of epilepsy with drug-induced DBN related to toxic levels of AEDs were summarized, and DBN was ...
Dongyan Wu, Roland D. Thijs
doaj +1 more source
Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]
, 2013 Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P +31 more
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