Results 21 to 30 of about 49,773 (253)

Substituted pyridines as sodium channel blockers: patent highlight. [PDF]

ACS Med Chem Lett, 2012
Blass B.
europepmc   +4 more sources

Locating the route of entry and binding sites of benzocaine and phenytoin in a bacterial voltage gated sodium channel. [PDF]

PLoS Computational Biology, 2014
Sodium channel blockers are used to control electrical excitability in cells as a treatment for epileptic seizures and cardiac arrhythmia, and to provide short term control of pain.
Lewis J Martin, Ben Corry
doaj   +1 more source

Protective Effect of Peptide Calcium Channel Blocker Omega-Hexatoxin-Hv1a on Epithelial Cell during Ischemia–Reperfusion Injury

Pharmaceuticals, 2023
Ischemia–reperfusion injury (IRI) is a common phenomenon that develops both from natural causes and during major operations. Many intracellular processes mediated by calcium ions are involved in the development of IRI. Currently, chemical calcium channel
Elena Iurova, Eugenia Rastorgueva, Evgenii Beloborodov, Evgeniya Pogodina, Aleksandr Fomin, Dmitrii Sugak, Denis Viktorov, Ivan Tumozov, Yury Saenko   +8 more
doaj   +1 more source

Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model.

PLoS Computational Biology, 2021
State-dependent sodium channel blockers are often prescribed to treat cardiac arrhythmias, but many sodium channel blockers are known to have pro-arrhythmic side effects.
Steffen S Docken, Colleen E Clancy, Timothy J Lewis   +2 more
doaj   +1 more source

Pharmacological Treatment for Atrial Fibrillation

Journal of Arrhythmia, 2005
Pharmacological treatment for atrial fibrillation has a variety of purposes, such as pharmacological defibrillation, maintenance of sinus rhythm, heart rate control to prevent congestive heart failure and prevention of both cerebral infarction and atrial
Kaoru Sugi, MD PhD, Mahito Noro, MD PhD, Takao Sakata, MD PhD, Naoki Tezuka, MD, Takeshi Nakae, MD, Kenta Kumagai, MD, Tsuyoshi Sakai, MD PhD, Ayaka Numata, MD PhD, Hidetoshi Itakura, MD, Akiyoshi Moriyama, MD, Shingo Kujime, MD   +10 more
doaj   +1 more source

Influence of antihypertensive therapy, sodium intake and the concentration of potassium in plasma on concentration of aldosterone and plasma renin activity [PDF]

Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2013
Introduction: Primary aldosteronism (PA) is a group of disorders which are characterized by inadequate and non-suppressible production of aldosterone. The prevalence of PA is increasing in hypertensive population.
Lalić Tijana
doaj   +1 more source

Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes

Frontiers in Pharmacology, 2011
Chronic and neuropathic pain constitute significant health problems affecting millions of individuals each year. Pain sensations typically originate in sensory neurons of the peripheral nervous system (PNS) which relay information to the central nervous
Jonathan W. Theile, Theodore R Cummins
doaj   +1 more source

Neonatal Episodic Laryngospasm Treated with Sodium Channel Blockers

Pediatric Neurology Briefs, 2010
Three male neonates with episodic laryngospasms responsive to sodium channel blockers are reported by researchers at centres in Lyon, Paris and Rennes, France.
J Gordon Millichap
doaj   +1 more source

Tuning Sodium Channel Blockers to the Near-Atomic Level. [PDF]

Epilepsy Curr
[Box: see text]
Eyal S.
europepmc   +3 more sources

Computational Design of High-Affinity Blockers for Sodium Channel Na_V1.2 from μ-Conotoxin KIIIA

Marine Drugs, 2022
The voltage-gated sodium channel subtype 1.2 (NaV1.2) is instrumental in the initiation of action potentials in the nervous system, making it a natural drug target for neurological diseases.
Guangsi Meng, Serdar Kuyucak
doaj   +1 more source