Results 41 to 50 of about 110,652 (333)
Spider neurotoxins targeting voltage-gated sodium channels [PDF]
, 2005 The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides, and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate sodium channel gating and/or kinetics.
Little, MJ, Nicholson, GM
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Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome [PDF]
Jichu yixue yu linchuang, 2020 Ion channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS).
LAN Fei, LIU Tai-yang, YANG Jie
doaj
Molecular basis of ion permeability in a voltage-gated sodium channel [PDF]
, 2016 Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events associated with action potentials.
Altin Sula +11 more
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Molecular Pain, 2011 Neuropathic pain is a common clinical condition. Current treatments are often inadequate, ineffective, or produce potentially severe adverse effects. Understanding the mechanisms that underlie the development and maintenance of neuropathic pain will be ...
Li Yun-Qing +3 more
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Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels [PDF]
, 2017 Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential.
Ahern +36 more
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, 2008 Voltage-gated ion channels are key molecules for the generation and propagation of electrical signals in excitable cell membranes. The voltage-dependent switching of these channels between conducting and nonconducting states is a major factor in ...
A. L. Hodgkin +6 more
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A Cation-π Interaction Discriminates among Sodium Channels That Are Either Sensitive or Resistant to Tetrodotoxin Block [PDF]
, 2007 Voltage-gated sodium channels control the upstroke of the action potential in excitable cells of nerve and muscle tissue, making them ideal targets for exogenous toxins that aim to squelch electrical excitability.
Ahern, Christopher A. +4 more
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The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia [PDF]
, 2015 BACKGROUND: Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG).
Kopach, O +3 more
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Voltage-gated sodium channels in taste bud cells
BMC Neuroscience, 2009 Background Taste bud cells transmit information regarding the contents of food from taste receptors embedded in apical microvilli to gustatory nerve fibers innervating basolateral membranes.
Williams Mark E +8 more
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Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling
eLife, 2020 Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer +5 more
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