Structural biology of voltage-gated calcium channels [PDF]
Channels, 2023 Voltage-gated calcium (Cav) channels mediate Ca2+ influx in response to membrane depolarization, playing critical roles in diverse physiological processes. Dysfunction or aberrant regulation of Cav channels can lead to life-threatening consequences.
Xia Yao, Shuai Gao, Nieng Yan
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Functions of Presynaptic Voltage-gated Calcium Channels [PDF]
Function, 2021 Voltage-gated calcium channels are the principal conduits for depolarization-mediated Ca2+ entry into excitable cells. In this review, the biophysical properties of the relevant members of this family of channels, those that are present in presynaptic ...
Annette C Dolphin
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Voltage-gated calcium channels in genetic epilepsies. [PDF]
J Neurochem, 2023 Abstract Voltage‐gated calcium channels (VGCC) are abundant in the central nervous system and serve a broad spectrum of functions, either directly in cellular excitability or indirectly to regulate Ca 2+ homeostasis.
Lauerer RJ, Lerche H.
europepmc +3 more sources
Voltage-Gated Calcium Channels in Nonexcitable Tissues. [PDF]
Annu Rev Physiol, 2021 The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted roles for the L-type voltage-gated Ca2+channel CaV1.2 in nonexcitable cells.
Pitt GS, Matsui M, Cao C.
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Regulation of GABAA Receptors Induced by the Activation of L-Type Voltage-Gated Calcium Channels [PDF]
Membranes, 2021 GABAA receptors are pentameric ion channels that mediate most synaptic and tonic extrasynaptic inhibitory transmissions in the central nervous system.
María Clara Gravielle
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Intercommunication between Voltage-Gated Calcium Channels and Estrogen Receptor/Estrogen Signaling: Insights into Physiological and Pathological Conditions [PDF]
Cells, 2022 Anamika Bhargava
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The Role of Voltage-Gated Calcium Channels in Basal Ganglia Neurodegenerative Disorders [PDF]
Current Neuropharmacology, 2023 Michael E Hildebrand
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Role of L-Type Voltage-Gated Calcium Channels in Epileptiform Activity of Neurons [PDF]
International Journal of Molecular Sciences, 2021 Artem Kosenkov +2 more
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Voltage-Gated Calcium Channels [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Voltage-gated calcium (Ca(2+)) channels are key transducers of membrane potential changes into intracellular Ca(2+) transients that initiate many physiological events. There are ten members of the voltage-gated Ca(2+) channel family in mammals, and they serve distinct roles in cellular signal transduction.
Paul R. Pentel +29 more
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Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function
Nature Communications, 2022 The function of voltage-gated calcium channels in T cells is not well understood and controversial. Here the authors report that a regulatory beta subunit of voltage-gated calcium channels regulates T cell function despite no evidence that these channels
Serap Erdogmus +14 more
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