Functions of Presynaptic Voltage-gated Calcium Channels [PDF]
Function, 2021 Voltage-gated calcium channels are the principal conduits for depolarization-mediated Ca2+ entry into excitable cells. In this review, the biophysical properties of the relevant members of this family of channels, those that are present in presynaptic ...
Annette C Dolphin
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Emerging roles of L-type voltage gated and other calcium channels in T lymphocytes. [PDF]
Frontiers in Immunology, 2013 In T lymphocytes, calcium ion controls a variety of biological processes including development, survival, proliferation, and effector functions. These distinct and specific roles are regulated by different calcium signals, which are generated by various ...
Abdallah eBadou +4 more
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Voltage-gated calcium channels in genetic epilepsies. [PDF]
J Neurochem, 2023 Abstract Voltage‐gated calcium channels (VGCC) are abundant in the central nervous system and serve a broad spectrum of functions, either directly in cellular excitability or indirectly to regulate Ca 2+ homeostasis.
Lauerer RJ, Lerche H.
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Structural biology of voltage-gated calcium channels [PDF]
ChannelsVoltage-gated calcium (Cav) channels mediate Ca2+ influx in response to membrane depolarization, playing critical roles in diverse physiological processes. Dysfunction or aberrant regulation of Cav channels can lead to life-threatening consequences.
Xia Yao, Shuai Gao, Nieng Yan
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Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels [PDF]
eLife, 2016 The auxiliary α2δ subunits of voltage-gated calcium channels are extracellular membrane-associated proteins, which are post-translationally cleaved into disulfide-linked polypeptides α2 and δ.
Ivan Kadurin +11 more
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Neurobiology of Disease, 2004 Prions are transmissible pathogens that cause neurodegenerative diseases, although the mechanisms behind the nervous system dysfunctions are unclear.
Malin K Sandberg +3 more
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Regulation of GABAA Receptors Induced by the Activation of L-Type Voltage-Gated Calcium Channels [PDF]
Membranes, 2021 GABAA receptors are pentameric ion channels that mediate most synaptic and tonic extrasynaptic inhibitory transmissions in the central nervous system.
María Clara Gravielle
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Voltage-Gated Calcium Channels in Nonexcitable Tissues. [PDF]
Annu Rev Physiol, 2021 The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted roles for the L-type voltage-gated Ca2+channel CaV1.2 in nonexcitable cells.
Pitt GS, Matsui M, Cao C.
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A subfraction obtained from the venom of the tarantula Poecilotheria regalis contains inhibitor cystine knot peptides and induces relaxation of rat aorta by inhibiting L-type voltage-gated calcium channels [PDF]
Toxicon: X, 2023 Venoms from tarantulas contain low molecular weight vasodilatory compounds whose biological action is conceived as part of the envenomation strategy due to its propagative effects. However, some properties of venom-induced vasodilation do not match those
Luis Fernando Díaz-Peña +8 more
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<i>In vivo</i> silencing of the thalamic Ca<sub>V</sub>3.1 voltage-gated calcium channels demonstrates their region-specific role in anesthetic mediated hypnosis. [PDF]
Exp Biol Med (Maywood)Timic Stamenic T +4 more
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