Results 11 to 20 of about 116,855 (342)

Voltage-Gated Calcium Channels [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
Voltage-gated calcium (Ca(2+)) channels are key transducers of membrane potential changes into intracellular Ca(2+) transients that initiate many physiological events. There are ten members of the voltage-gated Ca(2+) channel family in mammals, and they serve distinct roles in cellular signal transduction.
Paul R. Pentel, Mark G. LeSage, Mark G. LeSage, Paul R. Pentel, Lawrence H. Price, Tomasz Schneider, Maria-Inés López-Ibor, Juan J. López-Ibor, Mohammed Shoaib, Paul Newhouse, Heather Wilkins, Huaiyu Yang, George I. Papakostas, Tara L. White, Richard A. Depue, Brian L. Odlaug, Jon E. Grant, Joachim Liepert, Ian Hindmarch, Rosa M. M. de Almeida, Klaus A. Miczek, Joachim Liepert, Rodrigo Andrade, Barbara J. Mason, Charles J. Heyser, Michael M. Morgan, MacDonald J. Christie, Kim Wolff, Michael M. Morgan, MacDonald J. Christie   +29 more
openaire   +3 more sources

Voltage-gated calcium channels generate blastema Ca2+ fluxes restraining zebrafish fin regenerative outgrowth. [PDF]

Development
Le Bleu HK, Kioussi RG, Henner AL, Lewis VM, Stewart S, Stankunas K.   +5 more
europepmc   +3 more sources

Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function

Nature Communications, 2022
The function of voltage-gated calcium channels in T cells is not well understood and controversial. Here the authors report that a regulatory beta subunit of voltage-gated calcium channels regulates T cell function despite no evidence that these channels
Serap Erdogmus, Axel R. Concepcion, Megumi Yamashita, Ikjot Sidhu, Anthony Y. Tao, Wenyi Li, Pedro P. Rocha, Bonnie Huang, Ralph Garippa, Boram Lee, Amy Lee, Johannes W. Hell, Richard S. Lewis, Murali Prakriya, Stefan Feske   +14 more
doaj   +1 more source

Potential binding modes of the gut bacterial metabolite, 5-hydroxyindole, to the intestinal L-type calcium channels and its impact on the microbiota in rats

Gut Microbes, 2023
Intestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via its modulation ...
Barbora Waclawiková, Paulo Cesar Telles de Souza, Markus Schwalbe, Constantinos G. Neochoritis, Warner Hoornenborg, Sieger A. Nelemans, Siewert J. Marrink, Sahar El Aidy   +7 more
doaj   +1 more source

A Sea Anemone Lebrunia neglecta Venom Fraction Decreases Boar Sperm Cells Capacitation: Possible Involvement of HVA Calcium Channels

Toxins, 2022
Sea anemones produce venoms characterized by a complex mixture of low molecular weight compounds, proteins and peptides acting on voltage-gated ion channels. Mammal sperm cells, like neurons, are characterized by their ion channels. Calcium channels seem
Fernando Lazcano-Pérez, Karina Bermeo, Héctor Castro, Zayil Salazar Campos, Isabel Arenas, Ariana Zavala-Moreno, Sheila Narayán Chávez-Villela, Irma Jiménez, Roberto Arreguín-Espinosa, Reyna Fierro, Humberto González-Márquez, David E. Garcia, Judith Sánchez-Rodríguez   +12 more
doaj   +1 more source

Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review

Heliyon, 2023
Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
doaj   +1 more source

Characterization of voltage-gated Ca(2+) conductances in layer 5 neocortical pyramidal neurons from rats. [PDF]

PLoS ONE, 2009
Neuronal voltage-gated Ca(2+) channels are involved in electrical signalling and in converting these signals into cytoplasmic calcium changes. One important function of voltage-gated Ca(2+) channels is generating regenerative dendritic Ca(2+) spikes ...
Mara Almog, Alon Korngreen
doaj   +1 more source

Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

eLife, 2020
Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer, Marko A Popovic, Xante Wilders, Sara Grasman, Oriol Pavón Arocas, Maarten HP Kole   +5 more
doaj   +1 more source

Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases

Frontiers in Pharmacology, 2021
Dysfunctional skin barrier and impaired skin homeostasis may lead to or aggravate a series of dermatologic diseases. A large variety of biological events and bioactive molecules are involved in the process of skin wound healing and functional recovery ...
Min Wang, Yaoxiang Sun, Linli Li, Peipei Wu, Ocansey DKW, Ocansey DKW, Hui Shi   +6 more
doaj   +1 more source

Structural determinants of voltage-gating properties in calcium channels

eLife, 2021
Voltage-gated calcium channels control key functions of excitable cells, like synaptic transmission in neurons and the contraction of heart and skeletal muscles.
Monica L Fernández-Quintero, Yousra El Ghaleb, Petronel Tuluc, Marta Campiglio, Klaus R Liedl, Bernhard E Flucher   +5 more
doaj   +1 more source