Results 41 to 50 of about 64,891 (258)

Optogenetic Control of Voltage‐Gated Calcium Channels [PDF]

Angewandte Chemie, 2018
AbstractVoltage‐gated Ca2+ (CaV) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo‐tunable modulation of CaV channel activity in excitable mammalian cells.
Guolin Ma, Jindou Liu, Yuepeng Ke, Xin Liu, Minyong Li, Fen Wang, Gang Han, Yun Huang, Youjun Wang, Yubin Zhou   +9 more
openaire   +4 more sources

Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Cav 2.2) which is ameliorated by quinacrine treatment

Neurobiology of Disease, 2004
Prions are transmissible pathogens that cause neurodegenerative diseases, although the mechanisms behind the nervous system dysfunctions are unclear.
Malin K Sandberg, Peter Wallén, Martin A Wikström, Krister Kristensson   +3 more
doaj   +1 more source

Trafficking and stability of voltage-gated calcium channels [PDF]

Cellular and Molecular Life Sciences, 2011
Voltage-gated calcium channels are important mediators of calcium influx into electrically excitable cells. The amount of calcium entering through this family of channel proteins is not only determined by the functional properties of channels embedded in the plasma membrane but also by the numbers of channels that are expressed at the cell surface. The
Brett A, Simms, Gerald W, Zamponi
openaire   +2 more sources

Active dendrites regulate the spatiotemporal spread of signaling microdomains. [PDF]

PLoS Computational Biology, 2018
Microdomains that emerge from spatially constricted spread of biochemical signaling components play a central role in several neuronal computations.
Reshma Basak, Rishikesh Narayanan
doaj   +1 more source

A subfraction obtained from the venom of the tarantula Poecilotheria regalis contains inhibitor cystine knot peptides and induces relaxation of rat aorta by inhibiting L-type voltage-gated calcium channels

Toxicon: X, 2023
Venoms from tarantulas contain low molecular weight vasodilatory compounds whose biological action is conceived as part of the envenomation strategy due to its propagative effects. However, some properties of venom-induced vasodilation do not match those
Luis Fernando Díaz-Peña, Torres-Ortiz Daniela, Manuel B. Aguilar, Enoch Luis, Fernando Lazcano-Pérez, Roberto Arreguín-Espinosa, Arturo Hernandez-Cruz, César Ibarra-Alvarado, Alejandro García-Arredondo   +8 more
doaj   +1 more source

Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores. [PDF]

PLoS ONE, 2017
Decreased leptin-induced endothelium-dependent vasodilation has been reported in spontaneously hypertensive rats (SHR). Here, we report leptin-induced vasoconstriction in endothelium-denuded pulmonary artery and thoracic aorta from SHR and sought to ...
Samantha Gomart, Caroline Gaudreau-Ménard, Pascale Jespers, Omer Gurkan Dilek, Emeline Hupkens, Aliénor Hanthazi, Robert Naeije, Christian Melot, Nathalie Labranche, Laurence Dewachter, Kathleen Mc Entee   +10 more
doaj   +1 more source

Ion channel molecular complexes in vascular smooth muscle

Frontiers in Physiology, 2022
Ion channels that influence membrane potential and intracellular calcium concentration control vascular smooth muscle excitability. Voltage-gated calcium channels (VGCC), transient receptor potential (TRP) channels, voltage (KV), and Ca2+-activated K ...
Eric A. Pereira da Silva, Miguel Martín-Aragón Baudel, Manuel F. Navedo, Madeline Nieves-Cintrón   +3 more
doaj   +1 more source

Role of voltage-gated calcium channels in epilepsy [PDF]

Pflügers Archiv - European Journal of Physiology, 2009
It is well established that idiopathic generalized epilepsies (IGEs) show a polygenic origin and may arise from dysfunction of various types of voltage- and ligand-gated ion channels. There is an increasing body of literature implicating both high- and low-voltage-activated (HVA and LVA) calcium channels and their ancillary subunits in IGEs.
Gerald W, Zamponi, Philippe, Lory, Edward, Perez-Reyes   +2 more
openaire   +2 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source