Results 61 to 70 of about 62,302 (192)

Differential lipid dependence of the function of bacterial sodium channels.

PLoS ONE, 2013
The lipid bilayer is important for maintaining the integrity of cellular compartments and plays a vital role in providing the hydrophobic and charged interactions necessary for membrane protein structure, conformational flexibility and function.
Nazzareno D'Avanzo, Emily C McCusker, Andrew M Powl, Andrew J Miles, Colin G Nichols, B A Wallace   +5 more
doaj   +1 more source

Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability

, 2012
PubMed ID: 22870192This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Baker, MD, Alessandro Pristerà (146521), Kenji Okuse (146542), Pristera, A, Mark D Baker, Mark D. Baker (146531), Okuse, K, Kenji Okuse, Alessandro Pristerà   +8 more
core   +1 more source

Identification of putative potassium channel homologues in pathogenic protozoa [PDF]

, 2012
K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
Prole, D L, Neil V Marrion, Marrion, NV, David L Prole   +3 more
core   +1 more source

Inherited disorders of voltage-gated sodium channels [PDF]

Journal of Clinical Investigation, 2005
A variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm, and nervous system function have been traced to mutations in genes encoding voltage-gated sodium channels. Clinical severity among these conditions ranges from mild or even latent disease to life-threatening or incapacitating conditions.
openaire   +2 more sources

The actions of chloride channel blockers, barbiturates and a benzodiazepine on Caenorhabditis elegans glutamate- and ivermectin-gated chloride channel subunits expressed in Xenopus oocytes [PDF]

, 2009
The pharmacology of Caenorhabditis elegans glutamate-gated chloride (GluCl) channels was determined by making intracellular voltage-clamp recordings from Xenopus oocytes expressing GluCl subunits. As previously reported (Cully et al.
Bush, Elizabeth, Holden-Dye, Lindy, Foreman, Richard, Walker, Robert J.   +3 more
core   +1 more source

Sodium channels and mammalian sensory mechanotransduction

Molecular Pain, 2012
Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin, Rugiero Francois, Kiesewetter Hannes, Hatch Rachel, Hummler Edith, Nassar Mohammed A, Wang Fan, Wood John N   +7 more
doaj   +1 more source

Self-organized enhancement of conductivity in biological ion channels [PDF]

, 2013
We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels.
Kaufman, Igor, Khovanov, I. A., Khovanov, Igor A., McClintock, P. V. E., Eisenberg, Robert S., Luchinsky, Dmittri G., McClintock, Peter V. E., Eisenberg, R. S., Luchinsky, Dmitrii G., Tindjong, Rodrigue   +9 more
core   +1 more source

Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

eLife, 2014
Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for cation/proton antiporters ...
Paul G DeCaen, Yuka Takahashi, Terry A Krulwich, Masahiro Ito, David E Clapham   +4 more
doaj   +1 more source

Voltage-gated sodium channels in the mammalian heart

Global Cardiology Science and Practice, 2014
Mammalian species express nine functional voltage-gated Na(+) channels. Three of them, the cardiac-specific isoform Nav1.5 and the neuronal isoforms Nav1.8 and Nav1.9, are relatively resistant to the neurotoxin tetrodotoxin (TTX; IC50 ≥ 1 μM). The other six isoforms are highly sensitive to TTX with IC50 values in the nanomolar range. These isoforms are
Zimmer, Thomas, Haufe, Volker, Blechschmidt, Steve   +2 more
openaire   +2 more sources

Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies

Frontiers in Pharmacology, 2012
Voltage-gated sodium channels (VGSC) are multi-molecular protein complexes expressed in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi-spanning integral membrane glycoprotein (α-subunit) that can be associated ...
Eleonora eSavio Galimberti, Michael eGollob, Dawood eDarbar   +2 more
doaj   +1 more source