Results 51 to 60 of about 2,526,088 (292)

Neurological perspectives on voltage-gated sodium channels [PDF]

Brain, 2012
The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders.
Eijkelkamp, N, Linley, JE, Baker, MD, Minett, MS, Cregg, R, Werdehausen, R, Rugiero, F, Wood, JN   +7 more
openaire   +3 more sources

Developmental changes in voltage-gated calcium channel α(2)δ-subunit expression in the canine dorsal root ganglion [PDF]

, 2012
The voltage-gated calcium channel subunit (128 plays a fundamental role in propagation of excitatory signals associated with release of glutamate and neuropeptides substance P (SP) and calcitonin gene-related protein (CGRP).
K. Matiasek, Matiasek, K, Gualtiereo, G, Goedde, Th, F. Steffen, Reese, S, Rosati, M, T. Goedde, Steffen, Frank, Goedde, Thomas, Steffen, F, S. Reese, Rosati, Marco, Reese, Sven, De Risio, Luisa, Matiasek, Kaspar, L. De Risio, DeRisio, L, Gandini, Gualtiero   +18 more
core   +1 more source

Emerging Post‐CMOS Hardware Neurons for Brain‐Inspired Computing: Devices, Circuits, and System Integration

Advanced Functional Materials, EarlyView.
The physical realization of artificial neurons is a critical challenge for energy‐efficient neuromorphic computing. This review presents a comprehensive analysis of the evolution of artificial neuron implementations from conventional CMOS to emerging post‐CMOS technologies.
Kannan Udaya Mohanan, Hocheon Yoo, Benoît H. Lessard, Ioannis Kymissis, Chang‐Hyun Kim   +4 more
wiley   +1 more source

Bio‐Inspired Artificial Ionic Mechanoreceptor

Advanced Functional Materials, EarlyView.
A skin‐inspired artificial mechanoreceptor based on ionic interactions is presented for biomimetic tactile sensing. Pressure‐driven ionic redistribution within microfluidic channels generates a self‐powered electrical signal without external bias. The generated waveform exhibits mechanoreceptor‐like temporal features, including overshoot and undershoot,
Mohammad Akbari, Jeppe Don, Lasse A. N. Pedersen, John Noee, Rassoul Tabassian   +4 more
wiley   +1 more source

Photocontrol of Voltage-Gated Ion Channel Activity by Azobenzene Trimethylammonium Bromide in Neonatal Rat Cardiomyocytes. [PDF]

PLoS ONE, 2016
The ability of azobenzene trimethylammonium bromide (azoTAB) to sensitize cardiac tissue excitability to light was recently reported. The dark, thermally relaxed trans- isomer of azoTAB suppressed spontaneous activity and excitation propagation speed ...
Sheyda R Frolova, Olga Gaiko, Valeriya A Tsvelaya, Oleg Y Pimenov, Konstantin I Agladze   +4 more
doaj   +1 more source

Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channels [PDF]

, 2003
To understand functions of a single neuron, such as propagation and generation of synaptic or action potentials, a detailed description of the kinetics and distribution of the underlying ionic conductances is essential.
Korngreen, A, Helmstaedter, M., Helmstaedter, Moritz, Schaefer, AT, Korngreen, A., Schaefer, A., Sakmann, Bert, Helmstaedter, M, Sakmann, B, Schaefer, Andreas T., Korngreen, Alon, Sakmann, B., Helmstädter, Moritz   +12 more
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold

Channels
Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and ...
Phuong Tran Nguyen, Brandon John Harris, Diego Lopez Mateos, Adriana Hernández González, Adam Michael Murray, Vladimir Yarov-Yarovoy   +5 more
doaj   +1 more source

Covalent Functionalization of 2D Semiconductors: A Roadmap to Advanced Electronic Devices

Advanced Functional Materials, EarlyView.
This Review presents recent advances in the covalent functionalization strategies for two‐dimensional semiconductors and their implementation in modern technologies. Layered materials are modified through diverse molecular chemistries (e.g., thiols, diazonium salts, alkyl halides, and electron‐deficient species) to tailor their surface properties ...
Ramiro Quirós‐Ovies, Bin Han, Paolo Samorì   +2 more
wiley   +1 more source

Zur Wirkung des Seeanemonen Toxins II (ATX-II) auf spannungsgesteuerte Natriumionenkanäle neuronaler Zellen und zu den dadurch erreichten Änderungen im Schmerzempfinden [PDF]

, 2013
ATX-II wurde ursprünglich aus dem Gift der Seeanemone Anemonia sulcata isoliert und ist als potenter Aktivator spannungsgesteuerter Natriumionenkanäle (Navs) bekannt, da es einen persistierenden Na+-Strom induziert.
Klinger, Alexandra Birgit
core   +1 more source