Results 61 to 70 of about 2,526,088 (292)

Voltage-Gated Sodium Channels as Insecticide Targets [PDF]

, 2014
Voltage-gated sodium channels are critical for the generation and propagation of action potentials. They are the primary target of several classes of insecticides, including DDT, pyrethroids and sodium channel blocker insecticides (SCBIs). DDT and pyrethroids preferably bind to open sodium channels and stabilize the open state, causing prolonged ...
Kristopher S, Silver, Yuzhe, Du, Yoshiko, Nomura, Eugenio E, Oliveira, Vincent L, Salgado, Boris S, Zhorov, Ke, Dong   +6 more
openaire   +2 more sources

VKCDB: Voltage-gated potassium channel database

, 2004
Background: The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based component of the membrane potential and are thus central to many critical ...
Li, B., Gallin, W.J.
core   +1 more source

Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]

, 1992
The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
Quasthoff, Stefan, Mitrović, N., Strupp, Michael, Grafe, Peter   +3 more
core   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

Advanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker, Yuchen Liu, Miguel Baños, Rosanne Schmachtenberg, Mahmudul Hasan, Claudia Fink‐Straube, Luai R. Khoury, Wilfried Weber   +7 more
wiley   +1 more source

Adaptive evolution of scn4aa in Takifugu and Tetraodon

Aquaculture and Fisheries
Tetrodotoxin (TTX) is a potent neurotoxin firstly discovered in the ovary of pufferfish. The genetic basis of voltage-gated sodium channel resistance to TTX has been widely studied, but it remains unclear in the evolution history of voltage-gated sodium ...
Hexing Wu, Yonglai Hu, Jing Wang, Xiaoling Gong, Baolong Bao   +4 more
doaj   +1 more source

Voltage-Gated Sodium Channel expression and cancer [PDF]

, 2011
Deep insight on Voltage-Gated Sodium Channel expression and ...
Wang, Z
core   +1 more source

Nitride MXenes Beyond Carbides: Bridging the Gap Between Computational Prediction and Experimental Realization

Advanced Functional Materials, EarlyView.
Nitride MXenes remain constrained by a persistent gap between computational prediction and experimental realization. This Review identifies the thermodynamic, kinetic, and chemical barriers limiting their synthesis, critically evaluates emerging fabrication routes, and proposes a multidimensional computational‐experimental framework to accelerate the ...
Naresh Varnakavi, Masoud Soroush
wiley   +1 more source

Sudden cardiac arrest due to a single sodium channel mutation producing a mixed phenotype of Brugada and Long QT3 syndromes

Indian Pacing and Electrophysiology Journal, 2016
Inherited arrhythmia syndromes are a known, albeit rare, cause of sudden cardiac arrest which may present with characteristic electrocardiogram changes in patients with structurally normal heart.
U. Lakshmanadoss, A. Mertens, M. Gallagher, I. Kutinsky, B. Williamson   +4 more
doaj   +1 more source

Pyrethroid resistance in Sitophilus zeamais is associated with a mutation (T9291) in the voltage-gated sodium channel

, 2011
The maize weevil, Sitophilus zeamais, is the most important pest affecting stored grain in Brazil and its control relies heavily on the use of insecticides.
Field, L. M., Araujo, R. A., Martin S. Williamson, Ian R. Duce, Duce, I. R., Bass, C. G., Christopher Bass, Rúbia A. Araújo, Williamson, M. S., Linda M. Field   +9 more
core   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source