Results 61 to 70 of about 66,157 (301)

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Voltage-Gated Sodium Channels as Insecticide Targets [PDF]

, 2014
Voltage-gated sodium channels are critical for the generation and propagation of action potentials. They are the primary target of several classes of insecticides, including DDT, pyrethroids and sodium channel blocker insecticides (SCBIs). DDT and pyrethroids preferably bind to open sodium channels and stabilize the open state, causing prolonged ...
Kristopher S, Silver, Yuzhe, Du, Yoshiko, Nomura, Eugenio E, Oliveira, Vincent L, Salgado, Boris S, Zhorov, Ke, Dong   +6 more
openaire   +2 more sources

A Superfamily of Voltage-gated Sodium Channels in Bacteria [PDF]

Journal of Biological Chemistry, 2004
NaChBac, a six-alpha-helical transmembrane-spanning protein cloned from Bacillus halodurans, is the first functionally characterized bacterial voltage-gated Na(+)-selective channel. As a highly expressing ion channel protein, NaChBac is an ideal candidate for high resolution structural determination and structure-function studies.
Ryuta, Koishi, Haoxing, Xu, Dejian, Ren, Betsy, Navarro, Benjamin W, Spiller, Qing, Shi, David E, Clapham   +6 more
openaire   +2 more sources

Fructose‐Based Single‐Chain Polymer Nanoparticles for GLUT1–Mediated Delivery: Impact of Polymer Design on Uptake and In Vivo Performance

Advanced Healthcare Materials, EarlyView.
Single‐chain nanoparticles have been proposed as drug delivery carriers, but adding a tail can significantly enhance their performance. This was demonstrated using a tadpole‐like structure comprising a head prepared from a UV‐crosslinked fructose‐based glycopolymer capable of targeting GLUT receptors, combined with a PEG‐based tail. Compared with other
Hoang Yen Vo, Linqing Tian, Qiaoyun Wang, Evelyn Szabo, Rebecca Y. Lai, Fariba Dehghani, Martina H. Stenzel   +6 more
wiley   +1 more source

Gellan Gum Fluid Gel System for Controlled‐Delivery of Cytokine‐Licensed MSC‐EVs to Enhance Corneal Repair in Limbal Stem Cell Deficiency

Advanced Healthcare Materials, EarlyView.
Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh, Ava Dashti, Thomas E. Robinson, Robyn Gaffey, Richard Moakes, Neil Lagali, Liam Grover, Thomas Ritter   +7 more
wiley   +1 more source

The neurosteroid allopregnanolone sulfate inhibits Nav1.3 α subunit-containing voltage-gated sodium channels, expressed in Xenopus oocytes

Journal of Pharmacological Sciences, 2018
The neurosteroid allopregnanolone has potent analgesic effects, and its potential use for neuropathic pain is supported by recent reports. However, the analgesic mechanisms are obscure.
Takafumi Horishita, Nobuyuki Yanagihara, Susumu Ueno, Dan Okura, Reiko Horishita, Tomoko Minami, Yuichi Ogata, Yuka Sudo, Yasuhito Uezono, Takashi Kawasaki   +9 more
doaj   +1 more source

An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids [PDF]

, 2015
We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin.
T. G. E. Davies (7694750), Joanna S. Amey, O'Reilly, Andrias O., Mellor, I. R., Burton, Mark J., M. S. Williamson (7694747), Martin S. Williamson, Duce, I. R., Mellor, I.R., B.A. Wallace, Andrias O. O'Reilly, O'Reilly, A. O., Mark J. Burton, Burton, M. J., Field, L.M., A. O. O'Reilly (7694732), Amey, Joanna S., Puinean, A. M., Davies, T.G. Emyr, T.G. Emyr Davies, A. M. Puinean (7694735), O’Reilly, Andrias O., Williamson, Martin S., Amey, J.S., Duce, Ian R., Williamson, M.S., I. R. Mellor (7694738), Duce, I.R., Field, Linda M., Linda M. Field, Mark J. Burton (7691339), Field, L. M., Alin M. Puinean, Ian R. Duce, Amey, J. S., Wallace, B.A., Ian R. Mellor, J. S. Amey (7694729), Davies, T. G. E., Williamson, M. S., B. A. Wallace (148558), I. R. Duce (7694741), Wallace, Bonnie A., Puinean, Alin M., Mellor, Ian R., L. M. Field (7694744), Wallace, B. A., Davies, T.G.E., Burton, M.J., Puinean, A.M.   +49 more
core   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Identification of Navβ1 residues involved in the modulation of the sodium channel Nav1.4.

PLoS ONE, 2013
Voltage-gated sodium channels (VGSCs) are heteromeric protein complexes that initiate action potentials in excitable cells. The voltage-gated sodium channel accessory subunit, Navβ1, allosterically modulates the α subunit pore structure upon binding.
Angel A Islas, Alfredo Sánchez-Solano, Thomas Scior, Lourdes Millan-PerezPeña, Eduardo M Salinas-Stefanon   +4 more
doaj   +1 more source

Structure and function of voltage‐gated sodium channels

The Journal of Physiology, 1998
Sodium channels mediate fast depolarization and conduct electrical impulses throughout nerve, muscle and heart. This paper reviews the links between sodium channel structure and function. Sodium channels have a modular architecture, with distinct regions for the pore and the gates.
E, Marban, T, Yamagishi, G F, Tomaselli
openaire   +3 more sources