Results 41 to 50 of about 256,495 (250)

Fast-slow asymptotics for a Markov chain model of fast sodium current [PDF]

, 2017
We explore the feasibility of using fast-slow asymptotic to eliminate the computational stiffness of the discrete-state, continuous-time deterministic Markov chain models of ionic channels underlying cardiac excitability. We focus on a Markov chain model
Biktashev, V. N., Stary, T.
core   +2 more sources

Neurotoxins and their binding areas on voltage-gated sodium channels

Frontiers in Pharmacology, 2011
Voltage-gated Sodium Channels (VGSCs) are large transmembrane proteins that conduct sodium ions across the membrane and by doing so they generate signals of communication between many kinds of tissues.
Marijke eStevens, Steve ePeigneur, Jan eTytgat   +2 more
doaj   +1 more source

Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice [PDF]

, 2019
Potassium (K+) channels shape the response properties of neurons. Although enormous progress has been made to characterize K+ channels in the primary auditory neurons, the molecular identities of many of these channels and their contributions to hearing ...
Gratton, Michael Anne, Jones, Sherri M., Jones, Timothy A., Lee, Jeong Han, Park, Seojin, Pyott, Sonja J., Reijntjes, Daniël O. J., Schubert, Nick M. A., van Tuinen, Marcel, Vijayakumar, Sarath, Xia, Xiao-Ming, Yamoah, Ebenezer N.   +11 more
core   +5 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Shellfish Toxins Targeting Voltage-Gated Sodium Channels

Marine Drugs, 2013
Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in excitable neurons and other cells and are targeted by commonly used local anesthetics, antiarrhythmics, and anticonvulsants. They are also
Fan Zhang, Xunxun Xu, Tingting Li, Zhonghua Liu   +3 more
doaj   +1 more source

Channel diffusion of sodium in a silicate glass

, 2001
We use classical molecular dynamics simulations to study the dynamics of sodium atoms in amorphous Na$_2$O-4SiO$_2$. We find that the sodium trajectories form a well connected network of pockets and channels. Inside these channels the motion of the atoms
A.K. Jonscher, B. Roling, D.E. Day, D.L. Sidebottom, G.J. Kramer, G.N. Greaves, G.N. Greaves, G.N. Greaves, H. Kahnt, J. Horbach, J. Horbach, J. Oviedo, J.P. Hansen, K. Funke, K. Funke, M.D. Ingram, M.D. Ingram, N. Bansal, P. Jund, P. Maass, P. Maass, Philippe Jund, Rémi Jullien, S. Sen, S. Sen, S.R. Elliott, Walter Kob   +26 more
core   +1 more source

Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels [PDF]

, 2017
Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential.
Ahern, Ahuja, Altin Sula, Arrigoni, B.A. Wallace, Bagnéris, Bagnéris, Charalambous, DeCaen, DeCaen, Depienne, Fukuma, Gardella, Hille, Ito, Kapplinger, Koishi, Lenaeus, Li, McCusker, McNicholas, Mio, Naylor, Oelstrom, Payandeh, Payandeh, Powl, Qu, Ren, Shaya, Shen, Smart, Sula, Tang, Ulmschneider, Villalba-Galea, Zhang   +36 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background Mutations in the coding sequence of SCN5A, which encodes the cardiac Na+ channel α subunit, have been associated with inherited susceptibility to various arrhythmias.
Nobue Yagihara, Hiroshi Watanabe, Phil Barnett, Laetitia Duboscq‐Bidot, Atack C. Thomas, Ping Yang, Seiko Ohno, Kanae Hasegawa, Ryozo Kuwano, Stéphanie Chatel, Richard Redon, Jean‐Jacques Schott, Vincent Probst, Tamara T. Koopmann, Connie R. Bezzina, Arthur A. M. Wilde, Yukiko Nakano, Takeshi Aiba, Yoshihiro Miyamoto, Shiro Kamakura, Dawood Darbar, Brian S. Donahue, Daichi Shigemizu, Toshihiro Tanaka, Tatsuhiko Tsunoda, Masayoshi Suda, Akinori Sato, Tohru Minamino, Naoto Endo, Wataru Shimizu, Minoru Horie, Dan M. Roden, Naomasa Makita   +32 more
doaj   +1 more source