Results 51 to 60 of about 256,495 (250)

Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]

, 2019
As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M, Nguyen, Hai M, Wulff, Heike   +2 more
core   +1 more source

Slow Dynamics in Ion-Conducting Sodium Silicate Melts: Simulation and Mode-Coupling Theory

, 2005
A combination of molecular-dynamics (MD) computer simulation and mode-coupling theory (MCT) is used to elucidate the structure-dynamics relation in sodium-silicate melts (NSx) of varying sodium concentration.
Angell C. A., Götze W., Horbach J., Horbach J., J Horbach, Th Voigtmann   +5 more
core   +1 more source

Effects of Ranolazine on Wild-Type and Mutant hNav1.7 Channels and on DRG Neuron Excitability [PDF]

, 2010
Background: A direct role of sodium channels in pain has recently been confirmed by establishing a monogenic link between SCN9A, the gene which encodes sodium channel Nav1.7, and pain disorders in humans, with gain-of-function mutations causing severe ...
Mark Estacion, Stephen G Waxman, Sulayman D Dib-Hajj   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Dynamics of Sodium in Sodium Disilicate: Channel Relaxation and Sodium Diffusion [PDF]

Physical Review Letters, 2002
We use molecular dynamics computer simulations to study the dynamics of amorphous (Na_2O)2(SiO_2). We find that the Na ions move in channels embedded in a SiO_2 matrix. The characteristic distance between these channels gives rise to a prepeak in the structure factor at around q=0.95 A^-1.
Horbach, Juergen, Kob, Walter, Binder, Kurt   +2 more
openaire   +3 more sources

Behavior of ion channels controlled by electric potential difference and of Toll-type receptors in neuropathic pain pathophysiology

Revista Dor
BACKGROUND AND OBJECTIVES: Neuropathic pain is a severe and refractory medical condition, for which only partially effective treatments are currently available.
André Prato Schmidt, Sérgio Renato Guimarães Schmidt   +1 more
doaj   +1 more source

Strong G-Protein-Mediated Inhibition of Sodium Channels

Cell Reports, 2018
Voltage-gated sodium channels (VGSCs) are strategically positioned to mediate neuronal plasticity because of their influence on action potential waveform.
Glynis B. Mattheisen, Timur Tsintsadze, Stephen M. Smith   +2 more
doaj   +1 more source

Keratinocyte Biomarkers Distinguish Painful Diabetic Peripheral Neuropathy Patients and Correlate With Topical Lidocaine Responsiveness

Frontiers in Pain Research, 2021
This study investigated quantifiable measures of cutaneous innervation and algesic keratinocyte biomarkers to determine correlations with clinical measures of patient pain perception, with the intent to better discriminate between diabetic patients with ...
Phillip J. Albrecht, Phillip J. Albrecht, George Houk, Elizabeth Ruggiero, Marilyn Dockum, Margaret Czerwinski, Joseph Betts, James P. Wymer, Charles E. Argoff, Frank L. Rice, Frank L. Rice   +10 more
doaj   +1 more source

Energy-efficient coding with discrete stochastic events [PDF]

, 2002
We investigate the energy efficiency of signaling mechanisms that transfer information by means of discrete stochastic events, such as the opening or closing of an ion channel.
Herz, Andreas V. M., Laughlin, Simon B., Machens, Christian K., Schreiber, Susanne   +3 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source