Results 31 to 40 of about 256,495 (250)
Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart [PDF]
, 2015 With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes.
Close, Graeme L. +6 more
core +2 more sources
On Conduction in a Bacterial Sodium Channel
PLoS Computational Biology, 2012 Voltage-gated Na⁺-channels are transmembrane proteins that are responsible for the fast depolarizing phase of the action potential in nerve and muscular cells. Selective permeability of Na⁺ over Ca²⁺ or K⁺ ions is essential for the biological function of Na⁺-channels.
Simone Furini, Carmen Domene
openaire +5 more sources
Amiloride-Sensitive Sodium Channels and Pulmonary Edema
Pulmonary Medicine, 2011 The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance.
Mike Althaus +2 more
doaj +1 more source
Frontiers in Physiology, 2015 Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH +1 more
doaj +1 more source
Cannabidiol interactions with voltage-gated sodium channels
eLife, 2020 Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two
Lily Goodyer Sait +5 more
doaj +1 more source
Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. [PDF]
PLoS Computational Biology, 2010 Sodium channels are one of the most intensively studied drug targets. Sodium channel inhibitors (e.g., local anesthetics, anticonvulsants, antiarrhythmics and analgesics) exert their effect by stabilizing an inactivated conformation of the channels ...
Robert Karoly +4 more
doaj +1 more source
Molecular basis of ion permeability in a voltage-gated sodium channel [PDF]
, 2016 Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events associated with action potentials.
Altin Sula +11 more
core +2 more sources
Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme. [PDF]
, 2017 In this issue of EMBO Molecular Medicine, Decher et al (2017) identify a point mutation in the K2P2 (TREK‐1) potassium (K+) channel that changes function in just those ways expected to predispose to right ventricular outflow tract (RVOT) ventricular
Goldstein, Steve An
core +2 more sources
Matrix controlled channel diffusion of sodium in amorphous silica
, 2002 To find the origin of the diffusion channels observed in sodium-silicate glasses, we have performed classical molecular dynamics simulations of Na$_2$O--4SiO$_2$ during which the mass of the Si and O atoms has been multiplied by a tuning coefficient.
Bansal N +29 more
core +1 more source
New patents on topical anesthetics. [PDF]
, 2014 Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano +6 more
core +1 more source