Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA
Marine Drugs, 2019 µ-Conotoxin PIIIA, in the sub-picomolar, range inhibits the archetypal bacterial sodium channel NaChBac (NavBh) in a voltage- and use-dependent manner.
Rocio K. Finol-Urdaneta +8 more
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Structural Advances in Voltage-Gated Sodium Channels
Frontiers in Pharmacology, 2022 Voltage-gated sodium (NaV) channels are responsible for the rapid rising-phase of action potentials in excitable cells. Over 1,000 mutations in NaV channels are associated with human diseases including epilepsy, periodic paralysis, arrhythmias and pain ...
Daohua Jiang +5 more
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Self-organized enhancement of conductivity in biological ion channels [PDF]
, 2013 We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels.
Kaufman, Igor +9 more
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Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies
Frontiers in Pharmacology, 2012 Voltage-gated sodium channels (VGSC) are multi-molecular protein complexes expressed in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi-spanning integral membrane glycoprotein (α-subunit) that can be associated ...
Eleonora eSavio Galimberti +2 more
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A small fraction of strongly cooperative sodium channels boosts neuronal encoding of high frequencies. [PDF]
PLoS ONE, 2012 Generation of action potentials (APs) is a crucial step in neuronal information processing. Existing biophysical models for AP generation almost universally assume that individual voltage-gated sodium channels operate statistically independently, and ...
Min Huang, Maxim Volgushev, Fred Wolf
doaj +1 more source
Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels [PDF]
, 2014 Whilst fertilizing capacity depends upon a K+ conductance G? that allows the spermatozoon membrane potential Vm to be held at a negative value, the characteristics of this conductance in human sperm are virtually unknown.
Barratt, C.L.R.; id_orcid +8 more
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Pumilio binds para mRNA and requires nanos and brat to regulate sodium current in drosophila motoneurons [PDF]
, 2008 Homeostatic regulation of ionic currents is of paramount importance during periods of synaptic growth or remodeling. Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of sodium current (INa) and excitability in ...
Moffat, K G +12 more
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NaV1.6 and NaV1.7 channels are major endogenous voltage-gated sodium channels in ND7/23 cells.
PLoS ONE, 2019 ND7/23 cells are gaining traction as a host model to express peripheral sodium channels such as NaV1.8 and NaV1.9 that have been difficult to express in widely utilized heterologous cells, like CHO and HEK293.
Jisoo Lee +4 more
doaj +1 more source
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres
Frontiers in Pharmacology, 2015 Voltage-gated sodium channels are known to play a pivotal role in perception and transmission of pain sensations. Gain-of-function mutations in the genes encoding the peripheral neuronal sodium channels, hNav1.7-1.9, cause human painful diseases.
Roberta eCarbonara +8 more
doaj +1 more source
On Conduction in a Bacterial Sodium Channel
PLoS Computational Biology, 2012 Voltage-gated Na⁺-channels are transmembrane proteins that are responsible for the fast depolarizing phase of the action potential in nerve and muscular cells. Selective permeability of Na⁺ over Ca²⁺ or K⁺ ions is essential for the biological function of Na⁺-channels.
Simone Furini, Carmen Domene
openaire +5 more sources