Results 21 to 30 of about 247,522 (255)
NaV1.6 and NaV1.7 channels are major endogenous voltage-gated sodium channels in ND7/23 cells.
PLoS ONE, 2019 ND7/23 cells are gaining traction as a host model to express peripheral sodium channels such as NaV1.8 and NaV1.9 that have been difficult to express in widely utilized heterologous cells, like CHO and HEK293.
Jisoo Lee +4 more
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Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres
Frontiers in Pharmacology, 2015 Voltage-gated sodium channels are known to play a pivotal role in perception and transmission of pain sensations. Gain-of-function mutations in the genes encoding the peripheral neuronal sodium channels, hNav1.7-1.9, cause human painful diseases.
Roberta eCarbonara +8 more
doaj +1 more source
Amiloride-Sensitive Sodium Channels and Pulmonary Edema
Pulmonary Medicine, 2011 The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance.
Mike Althaus +2 more
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Cannabidiol interactions with voltage-gated sodium channels
eLife, 2020 Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two
Lily Goodyer Sait +5 more
doaj +1 more source
Frontiers in Physiology, 2015 Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH +1 more
doaj +1 more source
Sodium channels and mammalian sensory mechanotransduction
Molecular Pain, 2012 Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin +7 more
doaj +1 more source
Frontiers in Pharmacology, 2023 During the second half of the last century, the prevalent knowledge recognized the voltage-gated sodium channels (VGSCs) as the proteins responsible for the generation and propagation of action potentials in excitable cells.
Ana Laura Sanchez-Sandoval +3 more
doaj +1 more source
Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. [PDF]
PLoS Computational Biology, 2010 Sodium channels are one of the most intensively studied drug targets. Sodium channel inhibitors (e.g., local anesthetics, anticonvulsants, antiarrhythmics and analgesics) exert their effect by stabilizing an inactivated conformation of the channels ...
Robert Karoly +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Shellfish Toxins Targeting Voltage-Gated Sodium Channels
Marine Drugs, 2013 Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in excitable neurons and other cells and are targeted by commonly used local anesthetics, antiarrhythmics, and anticonvulsants. They are also
Fan Zhang +3 more
doaj +1 more source