Results 11 to 20 of about 256,495 (250)
Brain and Neuroscience Advances, 2018 In 2000, with the completion of the human genome project, nine related channels were found to comprise the complete voltage-gated sodium gene family and they were renamed Na V 1.1–Na V 1.9.
John N. Wood, Federico Iseppon
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Sodium channels and mammalian sensory mechanotransduction [PDF]
Molecular Pain, 2012 Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin +7 more
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NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels. [PDF]
PLoS ONE, 2013 NALCN is a member of the family of ion channels with four homologous, repeat domains that include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene from simple, extant multicellular organisms without nervous systems such as ...
Adriano Senatore +4 more
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The Emerging Chondrocyte Channelome [PDF]
Frontiers in Physiology, 2010 Chondrocytes are the resident cells of articular cartilage and are responsible for synthesising a range of collagenous and non-collagenous extracellular matrix macromolecules.
Richard Barrett-Jolley +3 more
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Frontiers in Pharmacology, 2023 During the second half of the last century, the prevalent knowledge recognized the voltage-gated sodium channels (VGSCs) as the proteins responsible for the generation and propagation of action potentials in excitable cells.
Ana Laura Sanchez-Sandoval +3 more
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VOLTAGE-GATED SODIUM CHANNELS AND CANCER: IS EXCITABILITY THEIR PRIMARY ROLE?
Frontiers in Pharmacology, 2015 Voltage-gated sodium channels (NaV) are molecular characteristics of excitable cells. Their activation, triggered by membrane depolarization, generates transient sodium currents that initiate action potentials in neurons and muscle cells. Sodium currents
Sébastien eRoger +3 more
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Effects of Electrical Remodeling on Atrial Fibrillation in Diabetes Mellitus
Reviews in Cardiovascular Medicine, 2023 Atrial fibrillation (AF) is one of the most common arrhythmias in medical practice. Diabetes mellitus (DM) is one of the independent risk factors for atrial fibrillation.
Ling-ling Qian +4 more
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Fenestropathy of Voltage-Gated Sodium Channels
Frontiers in Pharmacology, 2022 Voltage-gated sodium channels (Nav) are responsible for the initiation and propagation of action potentials in excitable cells. From pain to heartbeat, these integral membrane proteins are the ignition stations for every sensation and action in human ...
Tamer M. Gamal El-Din +2 more
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Excitability constraints on voltage-gated sodium channels. [PDF]
PLoS Computational Biology, 2007 We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
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Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster. [PDF]
PLoS ONE, 2013 β subunits of mammalian sodium channels play important roles in modulating the expression and gating of mammalian sodium channels. However, there are no orthologs of β subunits in insects.
Lingxin Wang +3 more
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