Results 71 to 80 of about 260,312 (303)

High-content screening identifies a role for Na+ channels in insulin production [PDF]

Royal Society Open Science, 2015
Insulin production is the central feature of functionally mature and differentiated pancreatic β-cells. Reduced insulin transcription and dedifferentiation have been implicated in type 2 diabetes, making drugs that could reverse these processes ...
Marta Szabat, Honey Modi, Reshma Ramracheya, Vroni Girbinger, Forson Chan, Jason T. C. Lee, Micah Piske, Sepehr Kamal, Yu Hsuan Carol Yang, Andrea Welling, Patrik Rorsman, James D. Johnson   +11 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Salt, sodium channels, and SGK1 [PDF]

Journal of Clinical Investigation, 2007
The hormone aldosterone increases extracellular fluid volume and blood pressure by activating epithelial Na+ channels (ENaCs). Serum- and glucocorticoid-induced kinase 1 (SGK1) is an aldosterone-stimulated signaling molecule that enhances distal nephron Na+ transport, in part by preventing the internalization of ENaCs from the plasma membrane.
David, Pearce, Thomas R, Kleyman
openaire   +2 more sources

Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability

, 2012
PubMed ID: 22870192This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Baker, MD, Alessandro Pristerà (146521), Kenji Okuse (146542), Pristera, A, Mark D Baker, Mark D. Baker (146531), Okuse, K, Kenji Okuse, Alessandro Pristerà   +8 more
core   +1 more source

Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies

Frontiers in Pharmacology, 2018
Eukaryotic voltage-gated sodium channels play key roles in physiology and are targets for many toxins and medically important drugs. Physiology, pharmacology, and general architecture of the channels has long been the subject of intensive research in ...
Denis B. Tikhonov, Boris S. Zhorov, Boris S. Zhorov   +2 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels

, 2001
Recent progress in the cloning of alpha (para) and beta (TipE) Na channel sub-units from Drosophila melanogaster (fruit fly) and Musca domestica (housefly) have facilitated functional expression studies of insect Na channels in Xenopus laevis oocytes ...
Peter N R Usherwood, Alan L Devonshire, Vais, H., Usherwood, P. N. R., Horia Vais, Martin S Williamson, Williamson, M. S., Devonshire, A. L.   +7 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

The tail of the cardiac sodium channel [PDF]

Channels, 2008
Addendum to: Human Heart Failure Is Associated With Abnormal C-Terminal Splicing Variants in the Cardiac Sodium Channel Lijuan L. Shang, Arnold E. Pfahnl, Shamarendra Sanyal, Zhe Jiao, Jon Allen, Kathrin Banach, John Fahrenbach, Daiana Weiss, W. Robert Taylor, A. Maziar Zafari, Samuel C. Dudley, Jr Circulation Research. 2007;101:1146.
Lijuan L, Shang, Ge, Gao, Samuel C, Dudley   +2 more
openaire   +2 more sources

Predictive 3D modelling of the interactions of pyrethroids with the voltage-gated sodium channels of ticks and mites

, 2014
Background: The pyrethroid insecticides are a very successful group of compounds that target invertebrate voltage-gated sodium channels and are widely used in the control of insects, ticks and mites.
Field, L.M., Williamson, M.S., González-Cabrera, J., Wallace, Bonnie A., Gozalez-Cabrera, J., Wallace, B. A., Turberg, A., Emyr Davies, T.G., Field, L. M., O'Reilly, A.O., O'Reilly, A. O., Davies, T. G. E., Williamson, M. S.   +12 more
core   +1 more source