Results 61 to 70 of about 256,495 (250)

Voltage-gated sodium channels in cancers

Biomarker Research
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate ...
Hengrui Liu, Jieling Weng, Christopher L.-H. Huang, Antony P. Jackson   +3 more
doaj   +1 more source

Alpha1 -adrenergic stimulation selectively enhances endothelium-mediated vasodilation in rat cremaster arteries. [PDF]

, 2018
We have systematically investigated how vascular smooth muscle α1 -adrenoceptor activation impacts endothelium-mediated vasodilation in isolated, myogenically active, rat cremaster muscle 1A arteries.
Braun, Andrew P, Davis, Michael J, Hill, Michael A, Mishra, Ramesh C, Rahman, Mohammad M, Wulff, Heike   +5 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects

Toxins, 2022
Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers to form ...
Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, Anne Baron   +5 more
doaj   +1 more source

Monte Carlo simulation for statistical mechanics model of ion channel cooperativity in cell membranes

, 2008
Voltage-gated ion channels are key molecules for the generation and propagation of electrical signals in excitable cell membranes. The voltage-dependent switching of these channels between conducting and nonconducting states is a major factor in ...
A. L. Hodgkin, A. V. Hill, B. Hille, D. J. Aidley, Ekrem Aydiner, P. Ghosh, Riza Erdem   +6 more
core   +1 more source

Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]

, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Kauferstein, Silke, Kendel, Yvonne, Kurz, Alexander, Mebs, Dietrich, Melaun, Christian, Nicke, Annette, Peigneur, Steve, Tytgat, Jan, Wunder, Cora   +8 more
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons

Molecular Pain, 2011
Background Voltage-gated sodium channels play key roles in acute and chronic pain processing. The molecular, biophysical, and pharmacological properties of sodium channel currents have been extensively studied for peripheral nociceptors while the ...
Smith Paula L, Mezeyova Janette, Hildebrand Michael E, Salter Michael W, Tringham Elizabeth, Snutch Terrance P   +5 more
doaj   +1 more source

When Is a Potassium Channel Not a Potassium Channel?

Function, 2022
Ever since they were first observed in Purkinje fibers of the heart, funny channels have had close connections to potassium channels. Indeed, funny channels were initially thought to produce a potassium current in the heart called IK2.
Eric Accili
doaj   +1 more source

Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines. [PDF]

, 2007
Ionic channel activity is involved in fundamental cellular behaviour and participates in cancerous features such as proliferation, migration and invasion which in turn contribute to the metastatic process.
Barascu, Aurélia, Besson, Pierre, Bougnoux, Philippe, Gruel, Yves, Iochmann, Sophie, Le Guennec, Jean-Yves, Lei, Ming, Raynal, Pierre-Ivan, Roger, Sébastien, Rollin, Jérôme   +9 more
core   +3 more sources