Results 41 to 50 of about 312,333 (268)
Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization
eLife, 2016 In CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, ATP-binding-induced dimerization of two cytosolic nucleotide binding domains (NBDs) opens the pore, and dimer disruption following ATP hydrolysis closes it.
Csaba Mihályi +2 more
doaj +1 more source
Ubiquitylation of Ion Channels
Physiology, 2005 Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ...
Abriel H, Staub O
openaire +3 more sources
Frontiers in Molecular Biosciences, 2021 Mass spectrometry-based proteomics methods are widely used to identify and quantify protein complexes involved in diverse biological processes. Specifically, tandem mass spectrometry methods represent an accurate and sensitive strategy for identifying ...
Mariela González-Avendaño +21 more
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Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
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Antibiotics, 2023 One of the global challenges of the 21st century is the increase in mortality from infectious diseases against the backdrop of the spread of antibiotic-resistant pathogenic microorganisms.
Olga S. Ostroumova, Svetlana S. Efimova
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New Challenges Resulting From the Loss of Function of Nav1.4 in Neuromuscular Diseases
Frontiers in Pharmacology, 2021 The voltage-gated sodium channel Nav1.4 is a major actor in the excitability of skeletal myofibers, driving the muscle force in response to nerve stimulation.
Sophie Nicole +3 more
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Scientific Reports, 2018 Bacterial lipopolysaccharides (LPS) activate the TRPA1 cation channels in sensory neurons, leading to acute pain and inflammation in mice and to aversive behaviors in fruit flies.
Justyna B. Startek +3 more
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CellsPacemaking activity in substantia nigra dopaminergic neurons is generated by the coordinated activity of a variety of distinct somatodendritic voltage- and calcium-gated ion channels. We investigated whether these functional interactions could arise from
Maya Belghazi +6 more
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FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons
eLife, 2014 Rapid firing of cerebellar Purkinje neurons is facilitated in part by a voltage-gated Na+ (NaV) ‘resurgent’ current, which allows renewed Na+ influx during membrane repolarization.
Haidun Yan +3 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source