Results 21 to 30 of about 312,868 (268)
Journal of Biological Chemistry, 2011 Ion channels are specialized transmembrane proteins that permit the passive flow of ions following their electrochemical gradients. In the airways, ion channels participate in the production of epithelium-based hydroelectrolytic secretions and in the control of intracellular Ca(2+) levels that will ultimately activate almost all lung cells, either ...
Miguel A, Valverde +5 more
openaire +2 more sources
Definition of two agonist types at the mammalian cold-activated channel TRPM8
eLife, 2016 Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood.
Annelies Janssens +8 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2023 BackgroundAcute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption ...
Viviana Delgado-Betancourt +26 more
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Scientific Reports, 2019 The excitability of neurons is tightly dependent on their ion channel repertoire. Among these channels, the leak sodium channel NALCN plays a crucial role in the maintenance of the resting membrane potential.
Malik Bouasse +4 more
doaj +1 more source
The diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation
Journal of Advanced Research, 2021 Background: Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl− channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid and sensation of pain.
Weiliang Bai, Mei Liu, Qinghuan Xiao
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VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
Nature Communications, 2016 The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle ...
Debapriya Ghosh +12 more
doaj +1 more source
Activity-dependent regulation of T-type calcium channels by submembrane calcium ions
eLife, 2017 Voltage-gated Ca2+ channels are involved in numerous physiological functions and various mechanisms finely tune their activity, including the Ca2+ ion itself.
Magali Cazade +3 more
doaj +1 more source
eLife, 2016 Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death.
Iordan Iordanov +3 more
doaj +1 more source
Pharmaceutical Biology, 2020 Context Ginsenoside Rb1, the main active ingredient of ginseng, exhibits ex vivo depression of store-operated calcium entry (SOCE) and related vasoconstriction in pulmonary arteries derived from pulmonary hypertension (PH) rats.
Rui-Xing Wang +8 more
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