Results 1 to 10 of about 2,648 (130)

Ca2+-activated Cl− channel TMEM16A inhibition by cholesterol promotes angiogenesis in endothelial cells

Journal of Advanced Research, 2021
Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension.
Qinghuan Xiao
exaly   +3 more sources

The diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation

Journal of Advanced Research, 2021
Background: Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl− channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid and sensation of pain.
Weiliang Bai, Qinghuan Xiao
exaly   +3 more sources

TMEM16A Ca2+-activated Cl− channel inhibition ameliorates acute pancreatitis via the IP3R/Ca2+/NFκB/IL-6 signaling pathway

Journal of Advanced Research, 2020
TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown.
Qinghuan Xiao
exaly   +3 more sources

The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin

Frontiers in Pharmacology, 2021
The transmembrane 16 (TMEM16) family contains 10 subtypes, and the function of each protein is different. TMEM16A is a calcium-activated chloride channel involved in physiological and pathological situations.
Mami Kato, Yasunori Takayama, Masataka Sunagawa   +2 more
exaly   +3 more sources

Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells [PDF]

eLife, 2015
Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-dependent chloride currents; neither the target, nor mechanism, is known. We demonstrate that secreted CLCA1 activates calcium-dependent chloride currents in HEK293T cells in a ...
Monica Sala-Rabanal, Zeynep Yurtsever, Colin G Nichols, Tom J Brett   +3 more
doaj   +3 more sources

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Frontiers in Pharmacology, 2019
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations.
Kelly Hensley, Karl Kunzelmann, Deanna Mohn   +2 more
exaly   +3 more sources

Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells

Membranes, 2021
Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi, Jiraporn Ousingsawat, Raquel Centeio, Rainer Schreiber, Karl Kunzelmann   +4 more
doaj   +1 more source

Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis

Cell Death and Disease, 2022
Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca2+-activated chloride channel, has been implicated in a variety of ...
Jiawei Guo, Zihao Song, Jie Yu, Chengyi Li, Chenchen Jin, Wei Duan, Xiu Liu, Yingying Liu, Shuai Huang, Yonghua Tuo, Fei Pei, Zhengyang Jian, Pengyu Zhou, Shaoyi Zheng, Zhaowei Zou, Feng Zhang, Quan Gong, Sijia Liang   +17 more
doaj   +1 more source

Expression of TMEM16A in Colorectal Cancer and Its Correlation With Clinical and Pathological Parameters

Frontiers in Oncology, 2021
TMEM16A is a recently identified calcium-activated chloride channel (CaCC) and its overexpression contributes to tumorigenesis and progression in several human malignancies.
Hongxia Li, Qiwei Yang, Sibo Huo, Sibo Huo, Zhenwu Du, Zhenwu Du, Fei Wu, Haiyue Zhao, Shifan Chen, Longfei Yang, Zhiming Ma, Yujie Sui   +11 more
doaj   +1 more source

Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f

Gastro Hep Advances, 2022
Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber, Ines Cabrita, Karl Kunzelmann   +2 more
doaj   +1 more source