Results 1 to 10 of about 2,953 (151)
Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression [PDF]
Cells, 2020 ANO1, a Ca2+-activated chloride channel, is highly expressed in glioblastoma cells and its surface expression is involved in their migration and invasion. However, the regulation of ANO1 surface expression in glioblastoma cells is largely unknown.
Gwan-Su Yi +2 more
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Acta Pharmaceutica Sinica B, 2021 Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca2+ activated Cl– channels (CaCCs) that are critical for physiological functions, such as epithelial secretion, smooth muscle contraction and sensory signal transduction. The attraction and interest
Yani Liu, Zongtao Liu, Kewei Wang
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ANO1: More Than Just Calcium-Activated Chloride Channel in Cancer
Frontiers in Oncology, 2022 ANO1, a calcium-activated chloride channel (CACC), is also known as transmembrane protein 16A (TMEM16A). It plays a vital role in the occurrence, development, metastasis, proliferation, and apoptosis of various malignant tumors.
Linna Zhang
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Acta Pharmaceutica Sinica B, 2021 Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic
Jian Gao, Xiangqing Xu, Kewei Wang
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Experimental and Molecular Pathology, 2020 Long non-coding RNAs (lncRNAs) have a particular expression in the testicular tissue and exhibit a regulatory function on the reproduction system. ANO1-AS2 (linc02584), as an lncRNA is located near the anoctamin1 (ANO1) gene. ANO1 is an important component of the transmembrane system exhibiting expression modifications in the idiopathic infertile men ...
Mohammadreza Saberiyan +2 more
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The emerging role of anoctamin-1 in cardiac and cerebrovascular diseases [PDF]
Frontiers in Cardiovascular MedicineCardiocerebral vascular disease has long been the leading cause of morbidity and mortality worldwide. Although there are many effective avenues for preventing and treating cardiocerebral vascular disease, further research is still needed to identify more
Jia-qi Zhang +6 more
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Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca2+ [PDF]
Nature CommunicationsANO1 plays a crucial role in determining numerous physiological functions, including epithelial secretion, yet its regulatory mechanisms remain incompletely understood. Here, we describe a fundamental dynamic regulation of ANO1 surface expression and Ca2+
Wei-Yin Lin +6 more
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Ano1 is a Prognostic Biomarker That is Correlated with Immune Infiltration in Colorectal Cancer
International Journal of General Medicine, 2022 Jun Chen,1,* Hongli Wang,2,* Fang Peng,3,* Haiyan Qiao,1 Linfeng Liu,1 Liang Wang,1 Bingbing Shang4 1Laboratory Animal Center, Dalian Medical University, Dalian, 116044, Liaoning Province, People’s Republic of China; 2Cardiology Department ...
Chen J +6 more
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Advanced Science, 2023 The application of immunotherapy in gastrointestinal (GI) cancers remains challenging because of the limited response rate and emerging therapeutic resistance.
Fangli Jiang +2 more
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ANO1: central role and clinical significance in non-neoplastic and neoplastic diseases [PDF]
Frontiers in ImmunologyAnoctamin 1 (ANO1), also known as TMEM16A, is a multifunctional protein that serves as a calcium-activated chloride channel (CaCC). It is ubiquitously expressed across various tissues, including epithelial cells, smooth muscle cells, and neurons, where ...
Yanghao Hu +10 more
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