Results 1 to 10 of about 6,059 (124)
Acta Pharmaceutica Sinica B, 2021 Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca2+ activated Cl– channels (CaCCs) that are critical for physiological functions, such as epithelial secretion, smooth muscle contraction and sensory signal transduction. The attraction and interest
Yani Liu, Zongtao Liu, Kewei Wang
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ANO1: More Than Just Calcium-Activated Chloride Channel in Cancer
Frontiers in Oncology, 2022 ANO1, a calcium-activated chloride channel (CACC), is also known as transmembrane protein 16A (TMEM16A). It plays a vital role in the occurrence, development, metastasis, proliferation, and apoptosis of various malignant tumors.
Saisai Guo, Linna Zhang, Na Li
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Acta Pharmaceutica Sinica B, 2021 Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic
Jian Gao, Xiangqing Xu, Kewei Wang
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Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression
Cells, 2020 ANO1, a Ca2+-activated chloride channel, is highly expressed in glioblastoma cells and its surface expression is involved in their migration and invasion. However, the regulation of ANO1 surface expression in glioblastoma cells is largely unknown.
Gwan-Su Yi +2 more
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Anoctamin-1 Cl Channels in Nociception: Activation by an -Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01 [PDF]
Molecular Pain, 2015 Background Anoctamin 1 (ANO1 or TMEM16A) Ca 2+ -gated Cl − channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl − concentrations ([Cl − ] i ) sensory neuronal Cl −
Farah Deba, Bret F. Bessac
doaj +2 more sources
Advanced Science, 2023 The application of immunotherapy in gastrointestinal (GI) cancers remains challenging because of the limited response rate and emerging therapeutic resistance.
Fangli Jiang +2 more
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Physiological Reports, 2020 A Ca2+‐activated Cl− channel protein, ANO1, is expressed in vascular smooth muscle cells where Cl− current is thought to potentiate contraction by contributing to membrane depolarization.
Vladimir V Matchkov +2 more
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Frontiers in Bioscience-Landmark, 2022 Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu +7 more
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Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. [PDF]
PLoS ONE, 2012 Head and neck squamous cell carcinoma (HNSCC) has the potential for early metastasis and is associated with poor survival. Ano1 (Dog1) is an established and sensitive marker for the diagnosis of gastrointestinal stromal tumors (GIST) and has recently ...
Christian Ruiz +10 more
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Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines. [PDF]
PLoS ONE, 2015 The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration.
Yohan Seo +6 more
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