Results 1 to 10 of about 2,978 (169)
Acta Pharmaceutica Sinica B, 2021 Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca2+ activated Cl– channels (CaCCs) that are critical for physiological functions, such as epithelial secretion, smooth muscle contraction and sensory signal transduction. The attraction and interest
Kewei Wang, Zong-Tao Liu, Yani Liu
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Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca2+ [PDF]
Nature CommunicationsANO1 plays a crucial role in determining numerous physiological functions, including epithelial secretion, yet its regulatory mechanisms remain incompletely understood. Here, we describe a fundamental dynamic regulation of ANO1 surface expression and Ca2+
Wei-Yin Lin +6 more
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The emerging role of anoctamin-1 in cardiac and cerebrovascular diseases [PDF]
Frontiers in Cardiovascular MedicineCardiocerebral vascular disease has long been the leading cause of morbidity and mortality worldwide. Although there are many effective avenues for preventing and treating cardiocerebral vascular disease, further research is still needed to identify more
Jia-qi Zhang +6 more
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Acta Pharmaceutica Sinica B, 2021 Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic
Kewei Wang +2 more
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ANO1: central role and clinical significance in non-neoplastic and neoplastic diseases [PDF]
Frontiers in ImmunologyAnoctamin 1 (ANO1), also known as TMEM16A, is a multifunctional protein that serves as a calcium-activated chloride channel (CaCC). It is ubiquitously expressed across various tissues, including epithelial cells, smooth muscle cells, and neurons, where ...
Yanghao Hu +10 more
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Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]
Scientific ReportsCalcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang +9 more
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Physiological Reports, 2020 A Ca2+‐activated Cl− channel protein, ANO1, is expressed in vascular smooth muscle cells where Cl− current is thought to potentiate contraction by contributing to membrane depolarization.
Vladimir Matchkov +2 more
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Mechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers [PDF]
Frontiers in ImmunologyGastrointestinal (GI) cancers are main causes of poor health, with most remaining difficult to treat effectively. Identifying new targets for treatment is crucial for improving the efficacy of tumour therapies and enhancing patient quality of life ...
Xiaoyue Zhang +6 more
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Advanced Science, 2023 The application of immunotherapy in gastrointestinal (GI) cancers remains challenging because of the limited response rate and emerging therapeutic resistance.
Cheng Zhang
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ER stress-induced ITPR1/ANO1 signaling drives trigeminal neuropathic pain through calcium-dependent neuronal hyperexcitability [PDF]
The Journal of Headache and PainBackground Endoplasmic reticulum (ER) stress has been implicated in various chronic pain conditions, but its role in trigeminal neuropathic pain (TNP) remains unclear.
Huan-Jun Lu +14 more
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