vGPCR-Mediated ANO1 Modulation of Apoptosis Regulates Lytic KSHV Infection [PDF]
VirusesKaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpesvirus that causes Kaposi’s sarcoma (KS), an endothelial cell-derived malignancy that primarily affects immunocompromised individuals.
Anisha Reddy Konakalla +3 more
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Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression
Cells, 2020 ANO1, a Ca2+-activated chloride channel, is highly expressed in glioblastoma cells and its surface expression is involved in their migration and invasion. However, the regulation of ANO1 surface expression in glioblastoma cells is largely unknown.
Jae-Yong Park +2 more
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A paradoxical increase of force development in saphenous and tail arteries from heterozygous ANO1 knockout mice [PDF]
Physiological Reports, 2020 A Ca2+‐activated Cl− channel protein, ANO1, is expressed in vascular smooth muscle cells where Cl− current is thought to potentiate contraction by contributing to membrane depolarization.
Christian Staehr +2 more
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ANO1: More Than Just Calcium-Activated Chloride Channel in Cancer
Frontiers in Oncology, 2022 ANO1, a calcium-activated chloride channel (CACC), is also known as transmembrane protein 16A (TMEM16A). It plays a vital role in the occurrence, development, metastasis, proliferation, and apoptosis of various malignant tumors.
Saisai Guo, Linna Zhang, Na Li
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Acta Pharmaceutica Sinica B, 2021 Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic
KeWei Wang, Liangren Zhang, Zhenming Liu
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ANO1 stabilizes partial EMT to drive colorectal cancer metastasis through PI3K/AKT/mTOR and ERK signaling pathways [PDF]
Scientific ReportsColorectal cancer (CRC) metastasis remains a clinically intractable challenge, where the partial epithelial-mesenchymal transition (partial EMT) state is a key driver of metastatic plasticity and treatment resistance.
Fei Wu +9 more
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The emerging role of anoctamin-1 in cardiac and cerebrovascular diseases [PDF]
Frontiers in Cardiovascular MedicineCardiocerebral vascular disease has long been the leading cause of morbidity and mortality worldwide. Although there are many effective avenues for preventing and treating cardiocerebral vascular disease, further research is still needed to identify more
Jia-qi Zhang +6 more
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Advanced Science, 2023 The application of immunotherapy in gastrointestinal (GI) cancers remains challenging because of the limited response rate and emerging therapeutic resistance.
Cheng Zhang, Lin Shen, Yuezong Bai
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Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca2+ [PDF]
Nature CommunicationsANO1 plays a crucial role in determining numerous physiological functions, including epithelial secretion, yet its regulatory mechanisms remain incompletely understood. Here, we describe a fundamental dynamic regulation of ANO1 surface expression and Ca2+
Wei-Yin Lin +6 more
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Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]
Scientific ReportsCalcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang +9 more
doaj +2 more sources