Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction [PDF]
Nature Communications, 2022 Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction.
Weijia Sun +21 more
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Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans [PDF]
Nature CommunicationsMechanotransduction channels are widely expressed in both vertebrates and invertebrates, mediating various physiological processes such as touch, hearing and blood-pressure sensing.
Wenjuan Zou +16 more
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Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1 [PDF]
Communications Biology, 2023 Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun +21 more
doaj +3 more sources
Mechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers [PDF]
Frontiers in ImmunologyGastrointestinal (GI) cancers are main causes of poor health, with most remaining difficult to treat effectively. Identifying new targets for treatment is crucial for improving the efficacy of tumour therapies and enhancing patient quality of life ...
Xiaoyue Zhang +6 more
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Role of Anoctamin-1 and Bestrophin-1 in Spinal Nerve Ligation-Induced Neuropathic Pain in Rats [PDF]
Molecular Pain, 2015 Background Calcium-activated chloride channels (CaCCs) activation induces membrane depolarization by increasing chloride efflux in primary sensory neurons that can facilitate action potential generation. Previous studies suggest that CaCCs family members
Jorge Baruch Pineda-Farias +7 more
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The emerging role of anoctamin-1 in cardiac and cerebrovascular diseases [PDF]
Frontiers in Cardiovascular MedicineCardiocerebral vascular disease has long been the leading cause of morbidity and mortality worldwide. Although there are many effective avenues for preventing and treating cardiocerebral vascular disease, further research is still needed to identify more
Jia-qi Zhang +6 more
doaj +3 more sources
Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1 [PDF]
Frontiers in PharmacologyColorectal cancer (CRC) and non-small cell lung cancer (NSCLC) remain among the most challenging malignancies to treat due to therapy complexity, adverse events, and dose-limiting toxicities, which often result in treatment failure. NSCLC, in particular,
Yohan Seo +15 more
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Design of Anticancer 2,4-Diaminopyrimidines as Novel Anoctamin 1 (ANO1) Ion Channel Blockers [PDF]
Molecules, 2020 Pyrimidine is a privileged scaffold in many synthetic compounds exhibiting diverse pharmacological activities, and is used for therapeutic applications in a broad spectrum of human diseases.
Taewoo Kim +8 more
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Anoctamin-1 affects the migration and invasion of anaplastic thyroid carcinoma cells [PDF]
Animal Cells and Systems, 2019 Anaplastic thyroid carcinoma (ATC) is a rare malignancy with very poor prognosis. The exact cause underlying its strong aggressive nature is not clear.
Jae-Young Kim +7 more
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Anoctamin 1/TMEM16A controls intestinal Cl− secretion induced by carbachol and cholera toxin [PDF]
Experimental and Molecular Medicine, 2019 Colitis: Intestinal membrane protein implicated in defective fluid secretion An ion channel, a membrane protein allowing ion transport, that controls the flow of chloride is needed for proper secretion of protective fluids in the intestine.
Byeongjun Lee +12 more
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