Mechanical Stress Modulates Calcium-Activated-Chloride Currents in Differentiating Lens Cells
Frontiers in Physiology, 2022 During accommodation, the lens changes focus by altering its shape following contraction and relaxation of the ciliary muscle. At the cellular level, these changes in shape may be accompanied by fluid flow in and out of individual lens cells.
Lisa Ebihara +3 more
doaj +1 more source
TMEM16A/ANO1: Current Strategies and Novel Drug Approaches for Cystic Fibrosis
Cells, 2021 Cystic fibrosis (CF) is the most common of rare hereditary diseases in Caucasians, and it is estimated to affect 75,000 patients globally. CF is a complex disease due to the multiplicity of mutations found in the CF transmembrane conductance regulator ...
Christie Mitri +3 more
doaj +1 more source
Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia. [PDF]
Proc Natl Acad Sci U S A, 2015 Significance Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate gland, a common disease in elderly men. Excessive testosterone is considered to cause BPH. However, its etiologic mechanisms are elusive.
Cha JY +13 more
europepmc +4 more sources
Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling
Frontiers in Physiology, 2020 Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
doaj +1 more source
Anoctamin-5-Myopathie : Klinik, Histologie und Proteom einer Hallenser Kohorte [PDF]
, 2023 Die Anoctamin-5-Myopathie ist eine der häufigsten Ursachen für hereditäre Myopathien in Nordeuropa. Klinisch und histologisch zeigt die Erkrankung ein äußerst heterogenes Bild. Ursächlich sind rezessive Mutationen im Anoctamin-5-Gen.
Richert, Caroline
core +1 more source
Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Yasunori Takayama +2 more
exaly +2 more sources
Attenuation of Ampullary Anoctamin 1 by the peritoneal fluid in rhesus macaques with spontaneous endometriosis†. [PDF]
Biol ReprodAbstract Altered peristaltic and ciliary dysfunction is a feature of females with endometriosis. To further explore this premise, we examined the ampulla of rhesus macaques (Macaca mulatta) with and without spontaneous endometriosis for the expression of adenylate kinase 7 (AK7), a mitochondrial-dwelling nucleotide converting enzyme with
Luo F, Slayden O.
europepmc +3 more sources
Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases [PDF]
, 2018 Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins.
Kevin J. Hendargo (5007257) +20 more
core +3 more sources
Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f
Gastro Hep Advances, 2022 Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber +2 more
doaj +1 more source
, 2012 We investigated the cellular distribution of the calcium-activated chloride channel (CaCC), anoctamin 1, in the urethra of mice, rats, and sheep by both immunofluorescence and PCR. We studied its role in urethral contractility by examining the effects of
Sancho González, María +2 more
core +2 more sources