Journal of Animal Reproduction and Biotechnology, 2022 Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the
Eun-A Ko, Min Seok Woo, Dawon Kang
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Definitions, 2020 Anoctamin-1 (986 aa, ~114 kDa) is encoded by the human ANO1 gene. This protein plays a role in calcium-dependent transport of chloride.
semanticscholar +2 more sources
Clinical significance of Anoctamin-1 gene at 11q13 in the development and progression of head and neck squamous cell carcinomas. [PDF]
Sci Rep, 2015 This study investigates the clinical significance of Anoctamin-1 gene mapping at 11q13 amplicon in both the development and progression of head and neck squamous cell carcinomas (HNSCC).
Rodrigo JP +10 more
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Transmembrane protein 16A/anoctamin 1 inhibitor T16A-A01 reversed monocrotaline-induced rat pulmonary arterial hypertension [PDF]
Pulmonary Circulation, 2020 Transmembrane protein 16A was involved in the development of the monocrotaline-induced pulmonary arterial hypertension model through ERK1/2 activation, and it was considered as potential target for pulmonary arterial hypertension treatment.
Jianye Xie +9 more
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Colonic Transit Disorder Mediated by Downregulation of Interstitial Cells of Cajal/Anoctamin-1 in Dextran Sodium Sulfate-induced Colitis Mice. [PDF]
J Neurogastroenterol Motil, 2019 Background/Aims Interstitial cells of Cajal (ICC) and their special calcium-activated chloride channel, anoctamin-1 (ANO1) play pivotal roles in regulating colonic transit.
Lu C +7 more
europepmc +2 more sources
Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]
Scientific ReportsCalcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang +9 more
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TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation.
Biomedicine & Pharmacotherapy, 2020 BACKGROUND Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention ...
Guijin Ma +7 more
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Temporal Expression Patterns of Clock Genes and Aquaporin 5/Anoctamin 1 in Rat Submandibular Gland Cells [PDF]
Frontiers in Physiology, 2017 Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues.
Ryouichi Satou +6 more
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Natural Product Research, 2020 Ten triterpenoid glycosides including two undescribed compounds (1 and 2) were isolated from the methanol extract of Allium ascalonicum rhizomes. These compounds were structurally elucidated to be 3β-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl-19α ...
N. Mai +12 more
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Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38–Mitogen-activated Protein Kinase–Dependent Apoptosis [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2018 Bong Sook Jhun +2 more
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