Results 41 to 50 of about 27,267,955 (206)
Anoctamin 1 mediates thermal pain as a heat sensor. [PDF]
Curr Neuropharmacol, 2013 Vertebrates can sense and avoid noxious heat that evokes pain. Many thermoTRP channels are associated with temperature sensation. TRPV1 is a representative ion channel that is activated by noxious heat. Anoctamin 1 (ANO1) is a Cl- channel activated by calcium that is highly expressed in small sensory neurons, colocalized with markers for nociceptors ...
Cho H, Oh U.
europepmc +4 more sources
Mechanical Stress Modulates Calcium-Activated-Chloride Currents in Differentiating Lens Cells
Frontiers in Physiology, 2022 During accommodation, the lens changes focus by altering its shape following contraction and relaxation of the ciliary muscle. At the cellular level, these changes in shape may be accompanied by fluid flow in and out of individual lens cells.
Lisa Ebihara +3 more
doaj +1 more source
TMEM16A/ANO1: Current Strategies and Novel Drug Approaches for Cystic Fibrosis
Cells, 2021 Cystic fibrosis (CF) is the most common of rare hereditary diseases in Caucasians, and it is estimated to affect 75,000 patients globally. CF is a complex disease due to the multiplicity of mutations found in the CF transmembrane conductance regulator ...
Christie Mitri +3 more
doaj +1 more source
Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia. [PDF]
Proc Natl Acad Sci U S A, 2015 Significance Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate gland, a common disease in elderly men. Excessive testosterone is considered to cause BPH. However, its etiologic mechanisms are elusive.
Cha JY +13 more
europepmc +4 more sources
Cellular Expression Profile for Interstitial Cells of Cajal in Bladder - A Cell Often Misidentified as Myocyte or Myofibroblast [PDF]
, 2012 Background: Interstitial cells of Cajal (ICC) have been identified in urinary bladder of several species, but their presence in mice remains uncertain.
Hill, Warren Gary +2 more
core +11 more sources
Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Yasunori Takayama +2 more
exaly +2 more sources
Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling
Frontiers in Physiology, 2020 Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
doaj +1 more source
Pain, 2022 Itch is an unpleasant sensation that evokes a desire to scratch. Pathologic conditions such as allergy or atopic dermatitis produce severe itching sensation. Mas-related G protein receptors (Mrgprs) are receptors for many endogenous pruritogens. However,
Hyesu Kim +11 more
semanticscholar +1 more source
British Journal of Pharmacology, 2022 Pharmacological inhibitors of TMEM16A (ANO1), a Ca2+‐activated Cl− channel, are important tools of research and possible therapeutic agents acting on smooth muscle, airway epithelia and cancer cells.
M. Genovese +6 more
semanticscholar +1 more source
Biochemical Pharmacology, 2022 Calcium-activated chloride channels (CaCC) provide a depolarizing stimulus to a variety of tissues through chloride efflux in response to a rise in internal Ca2+ and voltage.
Connor Jimenez +3 more
semanticscholar +1 more source