Role of Anoctamin-1 and Bestrophin-1 in Spinal Nerve Ligation-Induced Neuropathic Pain in Rats [PDF]
Molecular Pain, 2015 Background Calcium-activated chloride channels (CaCCs) activation induces membrane depolarization by increasing chloride efflux in primary sensory neurons that can facilitate action potential generation. Previous studies suggest that CaCCs family members
Jorge Baruch Pineda-Farias +7 more
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Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction [PDF]
Nature Communications, 2022 Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction.
Weijia Sun +21 more
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Design of Anticancer 2,4-Diaminopyrimidines as Novel Anoctamin 1 (ANO1) Ion Channel Blockers [PDF]
Molecules, 2020 Pyrimidine is a privileged scaffold in many synthetic compounds exhibiting diverse pharmacological activities, and is used for therapeutic applications in a broad spectrum of human diseases.
Taewoo Kim +8 more
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Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans [PDF]
Nature CommunicationsMechanotransduction channels are widely expressed in both vertebrates and invertebrates, mediating various physiological processes such as touch, hearing and blood-pressure sensing.
Wenjuan Zou +16 more
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Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1 [PDF]
Communications Biology, 2023 Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun +21 more
doaj +2 more sources
Anoctamin-1 in the juvenile rat urinary bladder. [PDF]
PLoS ONE, 2014 PURPOSE: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. MATERIALS AND METHODS: Bladders from 3 week old Wistar rats were studied.
Dominika A Bijos +2 more
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Transient Magnetothermal Neuronal Silencing Using the Chloride Channel Anoctamin 1 (TMEM16A) [PDF]
Frontiers in Neuroscience, 2018 Determining the role and necessity of specific neurons in a network calls for precisely timed, reversible removal of these neurons from the circuit via remotely triggered transient silencing.
Rahul Munshi +2 more
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Anoctamin-1 Cl− Channels in Nociception: Activation by an N-Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01 [PDF]
Molecular Pain, 2015 Farah Deba, Bret F Bessac
exaly +4 more sources
Mechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers [PDF]
Frontiers in ImmunologyGastrointestinal (GI) cancers are main causes of poor health, with most remaining difficult to treat effectively. Identifying new targets for treatment is crucial for improving the efficacy of tumour therapies and enhancing patient quality of life ...
Xiaoyue Zhang +6 more
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The emerging role of anoctamin-1 in cardiac and cerebrovascular diseases [PDF]
Frontiers in Cardiovascular MedicineCardiocerebral vascular disease has long been the leading cause of morbidity and mortality worldwide. Although there are many effective avenues for preventing and treating cardiocerebral vascular disease, further research is still needed to identify more
Jia-qi Zhang +6 more
doaj +2 more sources