Calcium-activated chloride channels anoctamin 1 and 2 promote murine uterine smooth muscle contractility [PDF]
American Journal of Obstetrics and Gynecology, 2014 Joy Vink +2 more
exaly +2 more sources
Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing [PDF]
BMC Molecular Biology, 2011 Abstract Background TMEM16A (Anoctamin 1; ANO1) is an eight transmembrane protein that functions as a calcium-activated chloride channel. TMEM16A in human exhibits alternatively spliced exons (6b, 13 and 15), which confer important roles in the regulation of channel function. Mouse Tmem16a is reported to consist of 25
O'Driscoll, Kate E +2 more
openaire +2 more sources
MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
Nature Communications, 2017 Downregulation of the anoctamin 1 calcium channel in airway epithelial cells contributes to pathology in cystic fibrosis. Here the authors show that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improves mucus dynamics in mouse ...
Florence Sonneville +7 more
doaj +1 more source
Disulfide Bond Connectivity and Oligomeric State of Anoctamin-1 [PDF]
Biophysical Journal, 2013 TMEM16A(a)/anoctamin-1 (Ano1) has been identified as a Ca-activated chloride channel. Using blue native PAGE, SDS-PAGE and chemical cross-linking, we have shown that the mouse Ano1 channel (mAno1) shares an obligate homodimeric architecture with the hCLC-1 channel (Fallah et al. Molecular & Cellular Proteomics 10.1074/mcp. M110.004697, 2011).
Schmalzing, Gunther +4 more
openaire +1 more source
Chloride – The Underrated Ion in Nociceptors
Frontiers in Neuroscience, 2020 In contrast to pain processing neurons in the spinal cord, where the importance of chloride conductances is already well established, chloride homeostasis in primary afferent neurons has received less attention.
Bettina U. Wilke +3 more
doaj +1 more source
Mechanical Stress Modulates Calcium-Activated-Chloride Currents in Differentiating Lens Cells
Frontiers in Physiology, 2022 During accommodation, the lens changes focus by altering its shape following contraction and relaxation of the ciliary muscle. At the cellular level, these changes in shape may be accompanied by fluid flow in and out of individual lens cells.
Lisa Ebihara +3 more
doaj +1 more source
Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f
Gastro Hep Advances, 2022 Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber +2 more
doaj +1 more source
Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract. [PDF]
Pflugers Arch, 2023 AbstractInflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide and ivermectin, are intensively discussed for the treatment of viral inflammatory airway infections.
Ousingsawat J +3 more
europepmc +4 more sources
Cells, 2020 TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik +2 more
doaj +1 more source
Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation
Cells, 2020 Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels
Madalena C. Pinto +6 more
doaj +1 more source