Results 51 to 60 of about 2,953 (148)
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
Structure-Function Analysis of the Anion-Selective Pore of Anoctamin-1 [PDF]
Biophysical Journal, 2011 The anoctamins are a newly described family of anion channels. It has been proposed that anoctamin-1 (Ano1) has 8 transmembrane segments (TMDs) with a re-entrant loop between the 5th and 6th TMD that participates in forming the selectivity filter. To clarify the detailed structure and function of this region, we used cysteine accessibility scanning ...
Yu, Kuai +2 more
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Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. [PDF]
PLoS ONE, 2013 Calcium (Ca(2+))-activated chloride (Cl(-)) channels (CaCCs) play a role in the modulation of action potentials and synaptic responses in the somatodendritic regions of central neurons. In the vertebrate retina, large Ca(2+)-activated Cl(-) currents (ICl(
Ji Hyun Jeon +4 more
doaj +1 more source
TMEM16A channel signalling microdomains in the regulation of vascular function
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley +1 more source
Anoctamin‐1 is expressed and functional in the Pulmonary Vascular Endothelium
The FASEB Journal, 2013 Background and Objective The expression and functional role of Anoctamin‐1 (ANO1), a Ca2+ activated Cl channel in the endothelial cells (EC) is unclear. We sought to confirm the presence of ANO1 in the pulmonary vascular EC (PVEC) and the effect of ANO1 activation on EC membrane potential (Vm).
Ayed Mamdouh Allawzi +3 more
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Histological and histochemical study of effect of dietary fibre in motility of stomach in male mice
Journal of the Pakistan Medical AssociationObjective: To investigate the relationship between dietary fibres and muscularis externa layer. Method: The experimental study was conducted at the Anatomy Department of the College of Medicine, Al- Nahrain University, Iraq, from November 2020 to April ...
Khulood Ayad Majeed +2 more
doaj +1 more source
Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow
The Journal of Physiology, EarlyView.Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley +1 more source
Anoctamin 1, a multi-modal player in pain and itch
Cell CalciumAnoctamin 1 (ANO1/TMEM16A) encodes a Ca2+-activated Cl- channel. Among ANO1's many physiological functions, it plays a significant role in mediating nociception and itch. ANO1 is activated by intracellular Ca2+ and depolarization. Additionally, ANO1 is activated by heat above 44 °C, suggesting heat as another activation stimulus.
Hyungsup Kim, Won-Sik Shim, Uhtaek Oh
openaire +2 more sources
TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
Frontiers in Pharmacology, 2019 The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann +8 more
doaj +1 more source