Results 71 to 80 of about 29,991,200 (152)
Update on cellular expression and function of ANO1 channels in urethral smooth muscle
The Journal of Physiology, EarlyView.Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley +1 more source
Expression of Anoctamin 1 in adult zebrafish [PDF]
, 2015 Anoctamin 1 (Ano1) codes for a calcium activated chloride channel that has recently been identified as a marker for gastrointestinal stromal tumors, as well as been shown to be selectively expressed by interstitial cells of Cajal (ICC) in the muscle ...
Brady, Clayton
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BMC Neuroscience, 2017 Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dependent Ca2+-activated Cl ...
Casilda V. Mura +4 more
doaj +1 more source
Anoctamin 5 (ANO5) Muscle Disorders: A Narrative Review
, 2022 Anoctaminopathy-5 refers to a group of hereditary skeletal muscle or bone disorders due to mutations in the anoctamin 5 (ANO5)-encoding gene, ANO5. ANO5 is a 913-amino acid protein of the anoctamin family that functions predominantly in phospholipid ...
Soontrapa, Pannathat +3 more
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Annals of Neurology, Volume 100, Issue 3, Page 547-558, September 2026.Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens +9 more
wiley +1 more source
Cloning and Heterologous Expression of Anoctamin Isoforms [PDF]
, 2013 학위논문 (석사)-- 서울대학교 치의학대학원 : 치의학과, 2013. 2. Frank Hong Yu.Anoctamin1 (Ano1) has Ca2+-activated Cl- channel (CaCC) character which has an important role in salivation.
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Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy
PROTEOMICS, Volume 26, Issue 9, Page 6-23, September 2026.ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling +6 more
wiley +1 more source
Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines. [PDF]
PLoS ONE, 2015 The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration.
Yohan Seo +6 more
doaj +1 more source
Molecular Mechanisms of Electric Signals Generated at Corneal Wounds
The FASEB Journal, Volume 40, Issue 16, 31 August 2026.Corneal injury triggers cell signaling (including calcium waves) leading to ion channel up‐regulation, increased ion pumping, and enhanced wound electric signals which stimulate wound healing. ABSTRACT Over 150 years ago, it was demonstrated that wounds produce electric fields and currents.
Brian Reid, Guillaume Luxardi, Min Zhao
wiley +1 more source
Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing [PDF]
, 2011 Background TMEM16A (Anoctamin 1; ANO1) is an eight transmembrane protein that functions as a calcium-activated chloride channel. TMEM16A in human exhibits alternatively spliced exons (6b, 13 and 15), which confer important roles in the ...
Fiona C Britton +2 more
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