Results 71 to 80 of about 5,018 (188)

Structure-Function Analysis of the Anion-Selective Pore of Anoctamin-1 [PDF]

Biophysical Journal, 2011
The anoctamins are a newly described family of anion channels. It has been proposed that anoctamin-1 (Ano1) has 8 transmembrane segments (TMDs) with a re-entrant loop between the 5th and 6th TMD that participates in forming the selectivity filter. To clarify the detailed structure and function of this region, we used cysteine accessibility scanning ...
Yu, Kuai, Cui, Yuanyuan, Hartzell, H. Criss   +2 more
openaire   +1 more source

Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. [PDF]

PLoS ONE, 2013
Calcium (Ca(2+))-activated chloride (Cl(-)) channels (CaCCs) play a role in the modulation of action potentials and synaptic responses in the somatodendritic regions of central neurons. In the vertebrate retina, large Ca(2+)-activated Cl(-) currents (ICl(
Ji Hyun Jeon, Sun Sook Paik, Myung-Hoon Chun, Uhtaek Oh, In-Beom Kim   +4 more
doaj   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Anoctamin‐1 is expressed and functional in the Pulmonary Vascular Endothelium

The FASEB Journal, 2013
Background and Objective The expression and functional role of Anoctamin‐1 (ANO1), a Ca2+ activated Cl channel in the endothelial cells (EC) is unclear. We sought to confirm the presence of ANO1 in the pulmonary vascular EC (PVEC) and the effect of ANO1 activation on EC membrane potential (Vm).
Ayed Mamdouh Allawzi, Alexander Vang, Anlong Li, Gaurav Choudhary   +3 more
openaire   +1 more source

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Frontiers in Pharmacology, 2019
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann, Jiraporn Ousingsawat, Inês Cabrita, Tereza Doušová, Andrea Bähr, Andrea Bähr, Melanie Janda, Rainer Schreiber, Roberta Benedetto   +8 more
doaj   +1 more source

Profound Re-Organization of Cell Surface Proteome in Equine Retinal Pigment Epithelial Cells in Response to In Vitro Culturing [PDF]

, 2012
The purpose of this study was to characterize the cell surface proteome of native compared to cultured equine retinal pigment epithelium (RPE) cells. The RPE plays an essential role in visual function and represents the outer blood-retinal barrier.
Aisenbrey, Alcazar, Alge, Bhutto, Bodaghi, Burke, Campochiaro, Christoph Szober, Chu, Claudia Alge-Priglinger, Clegg, Cornelia Deeg, Deeg, Deeg, Deeg, Deeg, Deeg, Degroote, Doherty, Dunn, Eberhardt, Ehrenhofer, Greer, Gullapalli, Gundersen, Ham, Hamel, Hauck, Hauck, Hauck, Hauck, Ho, Huang, Karl, Kerstin Euler, Kristina Fröhlich, Li, Limb, Machemer, Marius Ueffing, McBee, Milyushina, Mochizuki, Muramatsu, Nagai, Parker, Philp, Rizzolo, Rotilio, Singer, Stefanie Hauck, Strauss, Vacanti, Wolf, Wu   +54 more
core   +3 more sources

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Anoctamin 1, a multi-modal player in pain and itch

Cell Calcium
Anoctamin 1 (ANO1/TMEM16A) encodes a Ca2+-activated Cl- channel. Among ANO1's many physiological functions, it plays a significant role in mediating nociception and itch. ANO1 is activated by intracellular Ca2+ and depolarization. Additionally, ANO1 is activated by heat above 44 °C, suggesting heat as another activation stimulus.
Hyungsup Kim, Won-Sik Shim, Uhtaek Oh
openaire   +2 more sources

Histological and histochemical study of effect of dietary fibre in motility of stomach in male mice

Journal of the Pakistan Medical Association
Objective: To investigate the relationship between dietary fibres and muscularis externa layer. Method: The experimental study was conducted at the Anatomy Department of the College of Medicine, Al- Nahrain University, Iraq, from November 2020 to April ...
Khulood Ayad Majeed, Haider Abdal-Rasool Jaafar, Hussein Abbas Jarullah   +2 more
doaj   +1 more source

Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

Acta Pharmaceutica Sinica B, 2021
Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic
Yuxi Wang, Jian Gao, Song Zhao, Yan Song, Han Huang, Guiwang Zhu, Peili Jiao, Xiangqing Xu, Guisen Zhang, Kewei Wang, Liangren Zhang, Zhenming Liu   +11 more
doaj   +1 more source