Results 41 to 50 of about 5,018 (188)
Disulfide Bond Connectivity and Oligomeric State of Anoctamin-1 [PDF]
Biophysical Journal, 2013 TMEM16A(a)/anoctamin-1 (Ano1) has been identified as a Ca-activated chloride channel. Using blue native PAGE, SDS-PAGE and chemical cross-linking, we have shown that the mouse Ano1 channel (mAno1) shares an obligate homodimeric architecture with the hCLC-1 channel (Fallah et al. Molecular & Cellular Proteomics 10.1074/mcp. M110.004697, 2011).
Schmalzing, Gunther +4 more
openaire +1 more source
Chloride – The Underrated Ion in Nociceptors
Frontiers in Neuroscience, 2020 In contrast to pain processing neurons in the spinal cord, where the importance of chloride conductances is already well established, chloride homeostasis in primary afferent neurons has received less attention.
Bettina U. Wilke +3 more
doaj +1 more source
Molecular Sensors and Modulators of Thermoreception [PDF]
, 2015 Peer ...
Zhang, Xuming
core +1 more source
Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract. [PDF]
Pflugers Arch, 2023 AbstractInflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide and ivermectin, are intensively discussed for the treatment of viral inflammatory airway infections.
Ousingsawat J +3 more
europepmc +4 more sources
Cells, 2020 TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik +2 more
doaj +1 more source
Mechanical Stress Modulates Calcium-Activated-Chloride Currents in Differentiating Lens Cells
Frontiers in Physiology, 2022 During accommodation, the lens changes focus by altering its shape following contraction and relaxation of the ciliary muscle. At the cellular level, these changes in shape may be accompanied by fluid flow in and out of individual lens cells.
Lisa Ebihara +3 more
doaj +1 more source
Sublethal salinity stress contributes to habitat limitation in an endangered estuarine fish. [PDF]
, 2016 As global change alters multiple environmental conditions, predicting species' responses can be challenging without understanding how each environmental factor influences organismal performance.
Connon, Richard E +6 more
core +1 more source
Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f
Gastro Hep Advances, 2022 Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber +2 more
doaj +1 more source
ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human SCC-25 cells [PDF]
, 2013 Objectives: The purpose of this study is to confirm that ANO1 correlates with occurrence and metastasis of OSCC. Study Design: Immunohistochemistry was used to detect the expression of ANO1 in 160 specimens of OSCC and normal tissues.
Hong, Suling, Li, Yadong, Zhang, Jinsong
core +2 more sources
Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation
Cells, 2020 Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels
Madalena C. Pinto +6 more
doaj +1 more source