Results 41 to 50 of about 29,991,200 (152)

Anoctamin 6 regulates C2C12 myoblast proliferation. [PDF]

, 2014
Anoctamin 6 (Ano6) belongs to a conserved gene family (TMEM16) predicted to code for eight transmembrane proteins with putative Ca2+-activated chloride channel (CaCC) activity.
Andrew Mariano, Lixia Zhao, Lixia Zhao (174165), Sadia Mohsin, Audrey Torcaso (541543), Audrey Torcaso, Piming Zhao (439983), Andrew Mariano (541544), Renzhi Han (276195), Renzhi Han, Sadia Mohsin (541545), Piming Zhao, Li Xu, Li Xu (108702)   +13 more
core   +1 more source

Control of Ion Transport by Tmem16a Expressed in Murine Intestine

Frontiers in Physiology, 2019
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann, Raquel Centeio, Podchanart Wanitchakool, Inês Cabrita, Roberta Benedetto, Tultul Saha, Kazi Mirajul Hoque, Kazi Mirajul Hoque, Rainer Schreiber   +8 more
doaj   +1 more source

Effects of protein diet on expression of Anoctamin1 of Cajal cell in the nervous plexus of the stomach in male mice

Journal of the Pakistan Medical Association
Objective: To determine the association between a protein-rich diet and the expression of anoctamin 1 in Interstitial cells of Cajal within the muscle layer of the stomach wall in male mice.
Khulood Ayad Majeed, Haider Abdal-Rasool Jaafar, Hiba Majed Rasol   +2 more
doaj   +1 more source

Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells

, 2014
Polycystic kidney diseases are characterized by multiple bilateral renal cysts that gradually enlarge and lead to a decline in renal function. Cyst enlargement is driven by transepithelial chloride secretion, stimulated by enhanced levels of cyclic ...
Faria, Diana, Kunzelmann, Karl, Schreiber, Rainer, Eckardt, Kai-Uwe, Buchholz, Bjoern, Schley, Gunnar   +5 more
core   +1 more source

Novel mutations in the anoctamin 5 gene ( ANO5 ) associated with limb‐girdle muscular dystrophy 2L [PDF]

, 2013
Introduction: We present a Jordanian man with the typical LGMD 2L phenotype of early, asymmetric quadriceps weakness and subsequent biceps brachii weakness. Methods: Case report.
Little, Ann A., Mckeever, Paul E., Gruis, Kirsten L.   +2 more
core   +1 more source

Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

Nature Communications, 2019
The Ca2+-activated Cl- channel TMEM16A/Anoctamin 1 (ANO1) mediates secretion and intestinal motility in gastrointestinal epithelia and smooth muscle cells.
Anamika Dayal, Shu Fun J. Ng, Manfred Grabner   +2 more
doaj   +1 more source

Relationship between TMEM16A/anoctamin 1 and LRRC8A

, 2016
TMEM16A/anoctamin 1/ANO1 and VRAC/LRRC8 are independent chloride channels activated either by increase in intracellular Ca2+ or cell swelling, respectively. In previous studies, we observed overlapping properties for both types of channels.
Cabrita, Ines, Wanitchakool, Podchanart, Ousingsawat, Jiraporn, Amaral, Margarida, Kunzelmann, Karl, Benedetto, Roberta, Schreiber, Rainer, Sirianant, Lalida, Pankonien, Ines   +8 more
core   +1 more source

Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line

Stem Cell Research, 2022
The Transmembrane member 16A (TMEM16A), also known as anoctamin-1 (ANO1), is a calcium-activated chloride channel present in the airway epithelium. It is known to be involved in the apical chloride secretion indicating that TMEM16A could be addressed for
Mark-Christian Jaboreck, Jonathan Lukas Lühmann, Mia Mielenz, Frauke Stanke, Gudrun Göhring, Ulrich Martin, Ruth Olmer, Sylvia Merkert   +7 more
doaj   +1 more source

The Nature of Cell‐Penetrating Poly(disulfide)s

Angewandte Chemie International Edition, EarlyView.
The mode of action of cell‐penetrating poly(disulfide)s (CPDs) is elucidated to understand thiol‐mediated uptake (TMU) in general and guide future efforts to control cellular entry for chemicals delivery and pathogen defense. ABSTRACT Cell‐penetrating poly(disulfide)s (CPDs) are the most popular thiol‐mediated uptake (TMU) tools for delivering attached
Saidbakhrom Saidjalolov, Giacomo Renno, Yuheng Zhang, Michael Cognet, Justin Neuman, Andreas Hennig, Naomi Sakai, Stefan Matile   +7 more
wiley   +1 more source

Channelopathies – subcellular localisation of mutant proteins taking anoctamin-4 und bestrophin-1 as examples [PDF]

Einleitung: Ziel der immunzytochemischen Versuche war es, Anoctamin-4 (ein calciumabhängiger Kationenkanal) und Bestrophin-1 (ein calciumabhängiger Chloridkanal) sowie verschiedene Mutanten dieser Ionenkanäle hinsichtlich ihrer zellulären Lokalisation zu
Sturm, Ronja Fini
core   +1 more source