Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]
Scientific ReportsCalcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang +9 more
doaj +2 more sources
The role of anoctamin 1 in liver disease. [PDF]
J Cell Mol MedAbstractLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the ...
Li X +6 more
europepmc +3 more sources
Interaction between thermosensitive TRP channels and anoctamin 1. [PDF]
J Physiol SciSome thermosensitive transient receptor potential (TRP) channels form a protein complex with anoctamin 1 (ANO1, also called TMEM16A). TRP channels have high calcium permeability, and the calcium entering cells through TRP channel activation activates ANO1, a calcium-activated chloride channel, involved in many physiological and pathological conditions.
Takayama Y.
europepmc +3 more sources
Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38–Mitogen-activated Protein Kinase–Dependent Apoptosis [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2018 Bong Sook Jhun +2 more
exaly +2 more sources
Anoctamin 1 mediates thermal pain as a heat sensor. [PDF]
Curr Neuropharmacol, 2013 Vertebrates can sense and avoid noxious heat that evokes pain. Many thermoTRP channels are associated with temperature sensation. TRPV1 is a representative ion channel that is activated by noxious heat. Anoctamin 1 (ANO1) is a Cl- channel activated by calcium that is highly expressed in small sensory neurons, colocalized with markers for nociceptors ...
Cho H, Oh U.
europepmc +4 more sources
Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia. [PDF]
Proc Natl Acad Sci U S A, 2015 Significance Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate gland, a common disease in elderly men. Excessive testosterone is considered to cause BPH. However, its etiologic mechanisms are elusive.
Cha JY +13 more
europepmc +4 more sources
Frontiers in Pharmacology, 2023 Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growth and ...
SeonJu Park +20 more
doaj +1 more source
Combined quantification of the global proteome, phosphoproteome, and proteolytic cleavage to characterize altered platelet functions in the human Scott syndrome [PDF]
, 2016 The Scott syndrome is a very rare and likely underdiagnosed bleeding disorder associated with mutations in the gene encoding anoctamin-6. Platelets from Scott patients are impaired in various Ca(2+)-dependent responses, including phosphatidylserine ...
Burkhart, Julia M. +8 more
core +10 more sources
Folia Morphologica, 2023 BACKGROUND: Interstitial cells of Cajal (ICC) are widely distributed in human gastrointestinal (GI) tract, especially in the layer of muscularis externa between neurons and smooth muscles.
A. Al-Ahmadi +4 more
doaj +1 more source
Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling
Frontiers in Physiology, 2020 Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
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