Results 21 to 30 of about 2,959 (146)

Interaction between thermosensitive TRP channels and anoctamin 1. [PDF]

J Physiol Sci
Some thermosensitive transient receptor potential (TRP) channels form a protein complex with anoctamin 1 (ANO1, also called TMEM16A). TRP channels have high calcium permeability, and the calcium entering cells through TRP channel activation activates ANO1, a calcium-activated chloride channel, involved in many physiological and pathological conditions.
Takayama Y.
europepmc   +3 more sources

Anoctamin 1 mediates thermal pain as a heat sensor. [PDF]

Curr Neuropharmacol, 2013
Vertebrates can sense and avoid noxious heat that evokes pain. Many thermoTRP channels are associated with temperature sensation. TRPV1 is a representative ion channel that is activated by noxious heat. Anoctamin 1 (ANO1) is a Cl- channel activated by calcium that is highly expressed in small sensory neurons, colocalized with markers for nociceptors ...
Cho H, Oh U.
europepmc   +4 more sources

Chloride secretion, anoctamin 1 and Ca(2+) signaling. [PDF]

Channels (Austin), 2014
Kunzelmann K, Schreiber R.
europepmc   +4 more sources

Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2015
Daisuke Uta, Hidemasa Furue, Makoto Tominaga   +2 more
exaly   +2 more sources

ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers

Frontiers in Pharmacology, 2023
Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growth and ...
SeonJu Park, Raju Das, Nguyen Xuan Nhiem, Nguyen Xuan Nhiem, Sung Baek Jeong, Minuk Kim, Dongguk Kim, Hye In Oh, Su-Hyeon Cho, Oh-Bin Kwon, Jae-Hyeog Choi, Chul Soon Park, Song-Rae Kim, Uk Yeol Moon, Boksik Cha, Dong Kyu Choi, Sungwoo Lee, Wan Namkung, Joohan Woo, Joohan Woo, Yohan Seo   +20 more
doaj   +1 more source

Anoctamin 1 and c-Kit immunohistochemical study of interstitial cells of Cajal in the muscularis externa of human gastrointestinal tract

Folia Morphologica, 2023
BACKGROUND: Interstitial cells of Cajal (ICC) are widely distributed in human gastrointestinal (GI) tract, especially in the layer of muscularis externa between neurons and smooth muscles.
A. Al-Ahmadi, R. A. Mohammed, M. Atteya, T. A. Al-Matrafi, M. A. Alfayez   +4 more
doaj   +1 more source

Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling

Frontiers in Physiology, 2020
Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
doaj   +1 more source

Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells

Membranes, 2021
Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi, Jiraporn Ousingsawat, Raquel Centeio, Rainer Schreiber, Karl Kunzelmann   +4 more
doaj   +1 more source

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

FASEB BioAdvances, 2020
The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and secretion and
Henry Danahay, Roy Fox, Sarah Lilley, Holly Charlton, Kathryn Adley, Lee Christie, Ejaz Ansari, Camille Ehre, Alexis Flen, Michael J. Tuvim, Burton F. Dickey, Colin Williams, Sarah Beaudoin, Stephen P Collingwood, Martin Gosling   +14 more
doaj   +1 more source

Attenuation of Ampullary Anoctamin 1 by the peritoneal fluid in rhesus macaques with spontaneous endometriosis†. [PDF]

Biol Reprod
Abstract Altered peristaltic and ciliary dysfunction is a feature of females with endometriosis. To further explore this premise, we examined the ampulla of rhesus macaques (Macaca mulatta) with and without spontaneous endometriosis for the expression of adenylate kinase 7 (AK7), a mitochondrial-dwelling nucleotide converting enzyme with
Luo F, Slayden O.
europepmc   +3 more sources