Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling
Frontiers in Physiology, 2020 Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
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Frontiers in Bioscience-Landmark, 2022 Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu +7 more
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Anoctamin-5-Myopathie : Klinik, Histologie und Proteom einer Hallenser Kohorte [PDF]
, 2023 Die Anoctamin-5-Myopathie ist eine der häufigsten Ursachen für hereditäre Myopathien in Nordeuropa. Klinisch und histologisch zeigt die Erkrankung ein äußerst heterogenes Bild. Ursächlich sind rezessive Mutationen im Anoctamin-5-Gen.
Richert, Caroline
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Membranes, 2021 Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi +4 more
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Anoctamin-1 Cl(-) channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01. [PDF]
Molecular Pain, 2015 Bret F Bessac
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Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases [PDF]
, 2018 Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins.
Kevin J. Hendargo (5007257) +20 more
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FASEB BioAdvances, 2020 The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and secretion and
Henry Danahay +14 more
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Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract [PDF]
, 2023 Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide and ivermectin, are intensively discussed for the treatment of viral ...
Centeio, Raquel +3 more
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Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Daisuke Uta +2 more
exaly +2 more sources
Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract. [PDF]
Pflugers Arch, 2023 <jats:title>Abstract</jats:title><jats:p>Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines.
Ousingsawat J +3 more
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