Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity [PDF]
Molecular Pain, 2014 Background: Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli.
Byeongjun Lee +5 more
doaj +2 more sources
Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1 [PDF]
Frontiers in PharmacologyColorectal cancer (CRC) and non-small cell lung cancer (NSCLC) remain among the most challenging malignancies to treat due to therapy complexity, adverse events, and dose-limiting toxicities, which often result in treatment failure. NSCLC, in particular,
Yohan Seo +15 more
doaj +2 more sources
Light conditions affect rhythmic expression of aquaporin 5 and anoctamin 1 in rat submandibular glands [PDF]
Heliyon, 2019 Circadian rhythms regulate various physiological functions and are, therefore, essential for health. Light helps regulate the master and peripheral clocks. The secretion rates of saliva and electrolytes follow a circadian rhythm as well.
Ryouichi Satou +3 more
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Transmembrane protein 16A/anoctamin 1 inhibitor T16A-A01 reversed monocrotaline-induced rat pulmonary arterial hypertension [PDF]
Pulmonary Circulation, 2020 Transmembrane protein 16A was involved in the development of the monocrotaline-induced pulmonary arterial hypertension model through ERK1/2 activation, and it was considered as potential target for pulmonary arterial hypertension treatment.
Jianye Xie +9 more
doaj +2 more sources
Anoctamin 1/TMEM16A controls intestinal Cl− secretion induced by carbachol and cholera toxin [PDF]
Experimental and Molecular Medicine, 2019 Colitis: Intestinal membrane protein implicated in defective fluid secretion An ion channel, a membrane protein allowing ion transport, that controls the flow of chloride is needed for proper secretion of protective fluids in the intestine.
Byeongjun Lee +12 more
doaj +2 more sources
Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]
Scientific ReportsCalcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang +9 more
doaj +2 more sources
Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38-Mitogen-activated Protein Kinase-Dependent Apoptosis. [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2018 Gaurav Choudhary +2 more
exaly +2 more sources
Chloride secretion, anoctamin 1 and Ca2+ signaling [PDF]
Channels, 2014 Karl Kunzelmann, Rainer Schreiber
exaly +2 more sources
Frontiers in Pharmacology, 2023 Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growth and ...
SeonJu Park +20 more
doaj +1 more source
Folia Morphologica, 2023 BACKGROUND: Interstitial cells of Cajal (ICC) are widely distributed in human gastrointestinal (GI) tract, especially in the layer of muscularis externa between neurons and smooth muscles.
A. Al-Ahmadi +4 more
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