Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity [PDF]
Molecular Pain, 2014 Background: Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli.
Byeongjun Lee +5 more
doaj +5 more sources
Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate gland, a common disease in elderly men. Excessive testosterone is considered to cause BPH. However, its etiologic mechanisms are elusive. We found that ANO1, a Ca 2+ -activated
Ho-Young Lee +2 more
exaly +5 more sources
Anoctamin-1 is induced by TGF-β and contributes to lung myofibroblast differentiation
American Journal of Physiology - Lung Cellular and Molecular PhysiologyThis study describes a novel mechanism of differentiation of human lung fibroblasts (HLFs) to myofibroblasts: the key process in the pathogenesis of pulmonary fibrosis. Transforming growth factor-β (TGF-β) drives the expression of calcium-activated chloride channel anoctmin-1 (ANO1) leading to an increase in intracellular levels of chloride. The latter
Nickolai Dulin +2 more
exaly +4 more sources
Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1 [PDF]
Frontiers in PharmacologyColorectal cancer (CRC) and non-small cell lung cancer (NSCLC) remain among the most challenging malignancies to treat due to therapy complexity, adverse events, and dose-limiting toxicities, which often result in treatment failure. NSCLC, in particular,
Yohan Seo +15 more
doaj +2 more sources
Light conditions affect rhythmic expression of aquaporin 5 and anoctamin 1 in rat submandibular glands [PDF]
Heliyon, 2019 Circadian rhythms regulate various physiological functions and are, therefore, essential for health. Light helps regulate the master and peripheral clocks. The secretion rates of saliva and electrolytes follow a circadian rhythm as well.
Ryouichi Satou +3 more
doaj +2 more sources
Transmembrane protein 16A/anoctamin 1 inhibitor T16A-A01 reversed monocrotaline-induced rat pulmonary arterial hypertension [PDF]
Pulmonary Circulation, 2020 Transmembrane protein 16A was involved in the development of the monocrotaline-induced pulmonary arterial hypertension model through ERK1/2 activation, and it was considered as potential target for pulmonary arterial hypertension treatment.
Jianye Xie +9 more
doaj +2 more sources
Frontiers in Bioscience-Landmark, 2022 Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu +7 more
doaj +3 more sources
Anoctamin 1/TMEM16A controls intestinal Cl− secretion induced by carbachol and cholera toxin [PDF]
Experimental and Molecular Medicine, 2019 Colitis: Intestinal membrane protein implicated in defective fluid secretion An ion channel, a membrane protein allowing ion transport, that controls the flow of chloride is needed for proper secretion of protective fluids in the intestine.
Byeongjun Lee +12 more
doaj +2 more sources
Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]
Scientific ReportsCalcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang +9 more
doaj +2 more sources
The role of anoctamin 1 in liver disease. [PDF]
J Cell Mol MedAbstractLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the ...
Li X +6 more
europepmc +3 more sources