Chloride secretion, anoctamin 1 and Ca 2+ signaling [PDF]
Channels, 2014 Karl Kunzelmann, Rainer Schreiber
exaly +5 more sources
Voltage-Dependent Protonation of the Calcium Pocket Enable Activation of the Calcium-Activated Chloride Channel Anoctamin-1 (TMEM16A). [PDF]
Sci Rep, 2020 Anoctamin-1 (ANO1 or TMEM16A) is a homo-dimeric Ca 2+ -activated Cl − channel responsible for essential physiological processes. Each monomer harbours a pore and a Ca 2+ -binding pocket; the voltage-dependent binding of two intracellular Ca 2+ ions to ...
Segura-Covarrubias G +5 more
europepmc +3 more sources
Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials. [PDF]
J PhysiolCa2+ signalling plays a crucial role in determining lymphatic muscle cell excitability and contractility through its interaction with the Ca2+‐activated Cl− channel anoctamin 1 (ANO1).
Harlow RC +9 more
europepmc +2 more sources
Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis. [PDF]
J Allergy Clin Immunol, 2020 Background: The pathology of eosinophilic esophagitis (EoE) is characterized by eosinophil-rich inflammation, basal zone hyperplasia (BZH), and dilated intercellular spaces, and the underlying processes that drive the pathologic manifestations of the ...
Vanoni S +22 more
europepmc +2 more sources
miR-106a Targets Anoctamin 1 (ANO1) to Regulate Lipopolysaccharide (LPS)-Induced Inflammatory Response in Macrophages. [PDF]
Med Sci Monit, 2020 Background Sepsis is an organ dysfunction characterized by systemic inflammatory response. Micro(mi)ribonucleic acids take part in the regulation of the inflammatory response in many conditions. However, the role and mechanism of miR-106a and anoctamin 1
Heng J, Wu D, Lu S, Zhao Y.
europepmc +2 more sources
Transient Magnetothermal Neuronal Silencing Using the Chloride Channel Anoctamin 1 (TMEM16A) [PDF]
Frontiers in Neuroscience, 2018 Determining the role and necessity of specific neurons in a network calls for precisely timed, reversible removal of these neurons from the circuit via remotely triggered transient silencing.
Rahul Munshi +2 more
doaj +2 more sources
Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation
bioRxiv, 2023 Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs and resulting in deterioration in lung function.
E. Reed +10 more
semanticscholar +3 more sources
Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing [PDF]
BMC Molecular Biology, 2011 Background TMEM16A (Anoctamin 1; ANO1) is an eight transmembrane protein that functions as a calcium-activated chloride channel. TMEM16A in human exhibits alternatively spliced exons (6b, 13 and 15), which confer important roles in the ...
Kate E O'Driscoll +2 more
core +4 more sources
Anoctamin 1, a multi-modal player in pain and itch.
Cell CalciumAnoctamin 1 (ANO1/TMEM16A) encodes a Ca2+-activated Cl- channel. Among ANO1's many physiological functions, it plays a significant role in mediating nociception and itch. ANO1 is activated by intracellular Ca2+ and depolarization.
Hyungsup Kim, W. Shim, Uhtaek Oh
semanticscholar +3 more sources
Light conditions affect rhythmic expression of aquaporin 5 and anoctamin 1 in rat submandibular glands [PDF]
Heliyon, 2019 Circadian rhythms regulate various physiological functions and are, therefore, essential for health. Light helps regulate the master and peripheral clocks. The secretion rates of saliva and electrolytes follow a circadian rhythm as well.
Ryouichi Satou +3 more
doaj +2 more sources