Results 21 to 30 of about 21,238,471 (180)

Differential expression of anoctamin 1 in human epithelial ovarian cancer.

, 2021
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published and public microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of ...
Shahan Mamoor
openaire   +3 more sources

Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins

Frontiers in Bioscience-Landmark, 2022
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu, Meihan Chen, Qingwen Xu, Cheng Xue, Lili Fu, Kun Ling, Jinghua Hu, Changlin Mei   +7 more
doaj   +3 more sources

Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]

Scientific Reports
Calcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang, Kai Zheng, Liu Yang, Liying Liu, Haojian Han, Shuang Chen, Zhanning Qu, Kai Qin, Wansheng Zhang, Feng Hao   +9 more
doaj   +2 more sources

Triterpenoid glycosides from the rhizomes of Allium ascalonicum and their anoctamin-1 inhibitory activity

Natural Product Research, 2020
Ten triterpenoid glycosides including two undescribed compounds (1 and 2) were isolated from the methanol extract of Allium ascalonicum rhizomes. These compounds were structurally elucidated to be 3β-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl-19α-hydroxyolean-12-ene-28-oic acid 28-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl] ester (1), 3-O-β ...
Nguyễn Thị, Dương Thị Dung, Trần Thúy Nga, Vu Thi Xuan, Vũ Văn Đoán, Bùi Hữu Tài, Nguyễn Xuân Nhiệm, Phạm Hải Yến, Phan Văn Kiệm, Yohan Seo, W. Namkung, SeonJu Park, Seung Hyun Kim   +12 more
openaire   +3 more sources

Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
Cystic fibrosis (CF) airway epithelium is constantly subjected to injury events due to chronic infection and inflammation. Moreover, abnormalities in CF airway epithelium repair have been described and contribute to the lung function decline seen in CF patients. In the last past years, it has been proposed that anoctamin 1 (ANO1), a Ca(2+)-activated Cl(
Ruffin, Manon, Voland, Mélanie, Marie, Solenne, Bonora, Monique, Blanchard, Elise, Blouquit-Laye, Sabine, Naline, Emmanuel, Puyo, Philippe, Le Rouzic, Philippe, Guillot, Loic, Corvol, Harriet, Clement, Annick, Tabary, Olivier   +12 more
openaire   +5 more sources

Anoctamin-1 Cl Channels in Nociception: Activation by an -Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01 [PDF]

Molecular Pain, 2015
Background Anoctamin 1 (ANO1 or TMEM16A) Ca 2+ -gated Cl − channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl − concentrations ([Cl − ] i ) sensory neuronal Cl −
Farah Deba, Bret F. Bessac
doaj   +2 more sources

The role of anoctamin 1 in liver disease. [PDF]

J Cell Mol Med
AbstractLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the ...
Li X, Wang Y, Zhang L, Yao S, Liu Q, Jin H, Tuo B.   +6 more
europepmc   +3 more sources

Interaction between thermosensitive TRP channels and anoctamin 1. [PDF]

J Physiol Sci
Some thermosensitive transient receptor potential (TRP) channels form a protein complex with anoctamin 1 (ANO1, also called TMEM16A). TRP channels have high calcium permeability, and the calcium entering cells through TRP channel activation activates ANO1, a calcium-activated chloride channel, involved in many physiological and pathological conditions.
Takayama Y.
europepmc   +3 more sources

Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38–Mitogen-activated Protein Kinase–Dependent Apoptosis [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2018
Bong Sook Jhun, Dmitry Terentyev, Jin O-Uchi   +2 more
exaly   +2 more sources

Anoctamin 1 mediates thermal pain as a heat sensor. [PDF]

Curr Neuropharmacol, 2013
Vertebrates can sense and avoid noxious heat that evokes pain. Many thermoTRP channels are associated with temperature sensation. TRPV1 is a representative ion channel that is activated by noxious heat. Anoctamin 1 (ANO1) is a Cl- channel activated by calcium that is highly expressed in small sensory neurons, colocalized with markers for nociceptors ...
Cho H, Oh U.
europepmc   +4 more sources