Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice [PDF]
Frontiers in Nutrition, 2019 Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet.
Maria Paula Cornejo +2 more
exaly +11 more sources
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice [PDF]
BMC Neuroscience, 2001 Background The presynaptic protein α-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in α-synuclein null mutant mice.
Schoepfer Ralf, Specht Christian G
doaj +6 more sources
Susceptibility and transcriptional characteristics of inbred C57BL/6J and outbred ICR mice in CDAHFD-induced MASH models [PDF]
Laboratory Animal ResearchBackground Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive fibrotic liver disease, the underlying mechanisms of which have not been fully elucidated.
Jing Zhou +9 more
doaj +2 more sources
Inbred C57BL/6J and C57BL/6N mice exhibit differential vascular dysfunction compared with outbred UM-HET3 mice [PDF]
American Journal of Physiology-Heart and Circulatory PhysiologyWe observed major vascular physiological differences between C57BL/6J and C57BL/6N mice, indicating C57BL/6N mice have greater vascular function. However, in comparison to either C57BL/6 substrain, outbred, genetically diverse UM-HET3 mice have a greater vascular function characterized by lower aortic stiffness and greater endothelial-dependent ...
Mostafa Sabouri +6 more
openaire +3 more sources
Outbred mice as an appropriate model for evaluating the immunogenicity of vaccines against porcine circovirus 2 [PDF]
Open Veterinary JournalBackground: Porcine circovirus type 2 (PCV2) is the causative agent of porcine circovirus-associated diseases, leading to substantial economic losses in global swine production.
Vitor Barbosa Fialho Martins +9 more
doaj +2 more sources
Bone Brittleness Varies with Genetic Background in A/J and C57BL/6J Inbred Mice [PDF]
Journal of Bone and Mineral Research, 2001 Abstract The contribution of genetic and environmental factors to variations in bone quality are understood poorly. We tested whether bone brittleness varies with genetic background using the A/J and C57BL/6J inbred mouse strains.
Karl Jepsen +2 more
exaly +3 more sources
Growth Hormone Receptor Antagonism Extends Lifespan. [PDF]
Aging CellThis study provides proof of concept that GH antagonism in GH‐producing mice extends lifespan, supporting further investigation of GH antagonists as potential anti‐aging interventions in animals and humans. ABSTRACT Interventions that disrupt growth hormone (GH) action are recognized as some of the most potent methods for extending lifespan ...
List EO +5 more
europepmc +2 more sources
Shortcoming of the Mouse Model of Postoperative Ileus: Small Intestinal Lengths Have Similar Variations in In- and Outbred Mice and Cannot Be Predicted by Allometric Parameters [PDF]
BiomedicinesBackground/Objectives: The mouse model of postoperative ileus separates the gastrointestinal tract into 15 sections, 10 of which are in the small intestine, to measure intestinal transit time.
Maximiliane von Stumberg +3 more
doaj +2 more sources
Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice [PDF]
Physiology & Behavior, 2013 Human alcoholics display dramatic disruptions of circadian rhythms that may contribute to the maintenance of excessive drinking, thus creating a vicious cycle. While clinical studies cannot establish direct causal mechanisms, recent animal experiments have revealed bidirectional interactions between circadian rhythms and ethanol intake, suggesting that
Alan M, Rosenwasser, Michael C, Fixaris
openaire +2 more sources
OncoImmunology, 2022 Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic ...
Justin B. Hackett +9 more
doaj +1 more source