Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice [PDF]
Frontiers in Nutrition, 2019 Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet.
Maria Paula Cornejo +2 more
exaly +12 more sources
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice [PDF]
BMC Neuroscience, 2001 Background The presynaptic protein α-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in α-synuclein null mutant mice.
Schoepfer Ralf, Specht Christian G
doaj +6 more sources
Mixed genetic background better recapitulates developmental and psychiatric phenotypes and heterogeneity than inbred C57BL/6J mice [PDF]
Scientific ReportsPreclinical models of neurodevelopmental and psychiatric conditions often rely on inbred mouse strains like C57BL/6J (B6), which exhibit limited genetic and behavioral variability.
Ana Dudas +6 more
doaj +3 more sources
Susceptibility and transcriptional characteristics of inbred C57BL/6J and outbred ICR mice in CDAHFD-induced MASH models [PDF]
Laboratory Animal ResearchBackground Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive fibrotic liver disease, the underlying mechanisms of which have not been fully elucidated.
Jing Zhou +9 more
doaj +2 more sources
Shortcoming of the Mouse Model of Postoperative Ileus: Small Intestinal Lengths Have Similar Variations in In- and Outbred Mice and Cannot Be Predicted by Allometric Parameters [PDF]
BiomedicinesBackground/Objectives: The mouse model of postoperative ileus separates the gastrointestinal tract into 15 sections, 10 of which are in the small intestine, to measure intestinal transit time.
Maximiliane von Stumberg +3 more
doaj +2 more sources
Bone Brittleness Varies with Genetic Background in A/J and C57BL/6J Inbred Mice [PDF]
Journal of Bone and Mineral Research, 2001 Abstract The contribution of genetic and environmental factors to variations in bone quality are understood poorly. We tested whether bone brittleness varies with genetic background using the A/J and C57BL/6J inbred mouse strains.
Karl Jepsen +2 more
exaly +3 more sources
Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice [PDF]
Physiology & Behavior, 2013 Human alcoholics display dramatic disruptions of circadian rhythms that may contribute to the maintenance of excessive drinking, thus creating a vicious cycle. While clinical studies cannot establish direct causal mechanisms, recent animal experiments have revealed bidirectional interactions between circadian rhythms and ethanol intake, suggesting that
Alan M, Rosenwasser, Michael C, Fixaris
openaire +2 more sources
OncoImmunology, 2022 Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic ...
Justin B. Hackett +9 more
doaj +1 more source
Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks [PDF]
Neuroscience Letters, 2017 Inbred mouse strains have been used preferentially for behavioral testing over outbred counterparts, even though outbred mice reflect the genetic diversity in the human population better. Here, we compare the sociability of widely available outbred CD1 mice with the commonly used inbred C57BL/6J (C57) mice in the one-chamber social interaction test and
Lawrence S, Hsieh +4 more
openaire +2 more sources
Bone Reports, 2021 Mechanical unloading decreases bone volume and strength. In humans and mice, bone mineral density is highly heritable, and in mice the response to changes in loading varies with genetic background.
Michael A. Friedman +7 more
doaj +1 more source