Results 11 to 20 of about 1,340,693 (219)

Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity [PDF]

BMC Neuroscience, 2005
Background Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body.
Wu Fangbai, Enzinger Katherine M, Robbins Alicia I, Airey David C, Collins Christine E   +4 more
doaj   +2 more sources

Mixed genetic background better recapitulates developmental and psychiatric phenotypes and heterogeneity than inbred C57BL/6J mice

Scientific Reports
Preclinical models of neurodevelopmental and psychiatric conditions often rely on inbred mouse strains like C57BL/6J (B6), which exhibit limited genetic and behavioral variability.
Ana Dudas, Ana Novak, Caroline Gora, Emmanuel Pecnard, Nicolas Azzopardi, Séverine Morisset-Lopez, Lucie P. Pellissier   +6 more
doaj   +2 more sources

Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks [PDF]

Neuroscience Letters, 2017
Inbred mouse strains have been used preferentially for behavioral testing over outbred counterparts, even though outbred mice reflect the genetic diversity in the human population better. Here, we compare the sociability of widely available outbred CD1 mice with the commonly used inbred C57BL/6J (C57) mice in the one-chamber social interaction test and
Lawrence S, Hsieh, John H, Wen, Laura, Miyares, Paul J, Lombroso, Angélique, Bordey   +4 more
openaire   +2 more sources

Genetic variability affects the skeletal response to immobilization in founder strains of the diversity outbred mouse population

Bone Reports, 2021
Mechanical unloading decreases bone volume and strength. In humans and mice, bone mineral density is highly heritable, and in mice the response to changes in loading varies with genetic background.
Michael A. Friedman, Abdullah Abood, Bhavya Senwar, Yue Zhang, Camilla Reina Maroni, Virginia L. Ferguson, Charles R. Farber, Henry J. Donahue   +7 more
doaj   +1 more source

Generation of live offspring from vitrified mouse oocytes of C57BL/6J strain. [PDF]

PLoS ONE, 2013
In mammals, unfertilized oocytes are one of the most available stages for cryopreservation because the cryopreserved oocytes can be used for assisted reproductive technologies, including in vitro fertilization (IVF) and intracytoplasmic sperm injection ...
Natsuki Kohaya, Katsuyoshi Fujiwara, Junya Ito, Naomi Kashiwazaki   +3 more
doaj   +1 more source

Use of C57BL/6N mice on the variety of immunological researches

Laboratory Animal Research, 2017
Inbred mice are an essential animal strain for research as they can improve the reproducibility and reliability of study results. The establishment of new inbred lines is continuing, and new inbred lines are being used in many research fields. C57BL/6 is
Hyun Keun Song, Dae Youn Hwang
doaj   +1 more source

What’s in a (Sub)strain?

Stem Cell Reports, 2018
C57BL/6J and C57BL/6N inbred mice are widely, and often interchangeably, used for stem cell research; yet, these substrains harbor discrete genetic differences that can cause phenotypic disparities.
Jill M. Goldstein, Amy J. Wagers
doaj   +1 more source

Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells [PDF]

, 1975
Vaccinia virus specific cytotoxicity against infected target cells was observed in vitro. Spleen lymphocytes from normal and immunized mice of the inbred strains C3H and DBA/2 were incubated with vaccinia virus-infected and non-infected 51Cr-labeled ...
Koszinowski, Ulrich H., Thomssen, R., Thomssen, R, Koszinowski, U   +3 more
core   +1 more source

Absence of Embigin accelerates hearing loss and causes sub-viability, brain and heart defects in C57BL/6N mice due to interaction with Cdh23ahl

iScience, 2023
Summary: Mouse studies continue to help elaborate upon the genetic landscape of mammalian disease and the underlying molecular mechanisms. Here, we have investigated an Embigintm1b allele maintained on a standard C57BL/6N background and on a co-isogenic ...
Sherylanne Newton, Carlos Aguilar, Rosie K. Bunton-Stasyshyn, Marisa Flook, Michelle Stewart, Walter Marcotti, Steve Brown, Michael R. Bowl   +7 more
doaj   +1 more source

Inter-strain differences of serotonergic inhibitory pain control in inbred mice [PDF]

, 2010
Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Albuquerque Boris, Irmgard Tegeder, Tegeder Irmgard, Laura Popp, Wijnvoord, Nina, Myrczek, Thekla, Tegeder, Irmgard, Wijnvoord Nina, Popp, Laura, Annett Häussler, Häussler, Annett, Nina Wijnvoord, Myrczek Thekla, Häussler Annett, Popp Laura, Boris Albuquerque, Albuquerque, Boris, Thekla Myrczek   +17 more
core   +1 more source