Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice [PDF]
Frontiers in Nutrition, 2019 Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet.
Pablo N. De Francesco +6 more
doaj +7 more sources
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice [PDF]
BMC Neuroscience, 2001 Background The presynaptic protein α-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in α-synuclein null mutant mice.
Schoepfer Ralf, Specht Christian G
doaj +4 more sources
Bone Brittleness Varies with Genetic Background in A/J and C57BL/6J Inbred Mice [PDF]
Journal of Bone and Mineral Research, 2001 Abstract The contribution of genetic and environmental factors to variations in bone quality are understood poorly. We tested whether bone brittleness varies with genetic background using the A/J and C57BL/6J inbred mouse strains.
K J, Jepsen +4 more
openaire +4 more sources
Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice [PDF]
Physiology & Behavior, 2013 Human alcoholics display dramatic disruptions of circadian rhythms that may contribute to the maintenance of excessive drinking, thus creating a vicious cycle. While clinical studies cannot establish direct causal mechanisms, recent animal experiments have revealed bidirectional interactions between circadian rhythms and ethanol intake, suggesting that
Alan M, Rosenwasser, Michael C, Fixaris
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Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks [PDF]
Neuroscience Letters, 2017 Inbred mouse strains have been used preferentially for behavioral testing over outbred counterparts, even though outbred mice reflect the genetic diversity in the human population better. Here, we compare the sociability of widely available outbred CD1 mice with the commonly used inbred C57BL/6J (C57) mice in the one-chamber social interaction test and
Lawrence S, Hsieh +4 more
openaire +2 more sources
Quantitative Trait Loci That Determine BMD in C57BL/6J and 129S1/SvImJ Inbred Mice [PDF]
Journal of Bone and Mineral Research, 2006 Abstract BMD is highly heritable; however, little is known about the genes. To identify loci controlling BMD, we conducted a QTL analysis in a (B6 × 129) F2 population of mice. We report on additional QTLs and also narrow one QTL by combining the data from multiple crosses and through haplotype analysis.
Ishimori, N +12 more
openaire +3 more sources
Corticotropin-releasing factor receptors couple to multiple g-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning [PDF]
, 2003 Corticotropin-releasing factor (CRF) exerts a key neuroregulatory control on stress responses in various regions of the mammalian brain, including the hippocampus.
Blank, T. (Thomas) +5 more
core +2 more sources
iScience, 2023 Summary: Mouse studies continue to help elaborate upon the genetic landscape of mammalian disease and the underlying molecular mechanisms. Here, we have investigated an Embigintm1b allele maintained on a standard C57BL/6N background and on a co-isogenic ...
Sherylanne Newton +7 more
doaj +1 more source
Inter-strain differences of serotonergic inhibitory pain control in inbred mice [PDF]
, 2010 Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Wijnvoord, Nina +5 more
core +2 more sources
Experimentation with Animals: A Key Aspect of the 3Rs. The Genetic Quality [PDF]
, 2019 The genetic quality of laboratory animals is essential for reproducibility of scientific research. Working with animals of certifiedgenetic quality is still a pending issue in Argentina due to the lack of routine genetic controls, of information on the ...
Castillo, Nadia Sabiela +4 more
core +1 more source