Results 11 to 20 of about 1,442,388 (221)
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice [PDF]
BMC Neuroscience, 2001 Background The presynaptic protein α-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in α-synuclein null mutant mice.
Schoepfer Ralf, Specht Christian G
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Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice [PDF]
Frontiers in Nutrition, 2019 Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet.
Pablo N. De Francesco +6 more
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Susceptibility and transcriptional characteristics of inbred C57BL/6J and outbred ICR mice in CDAHFD-induced MASH models [PDF]
Laboratory Animal ResearchBackground Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive fibrotic liver disease, the underlying mechanisms of which have not been fully elucidated.
Jing Zhou +9 more
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Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity [PDF]
BMC Neuroscience, 2005 Background Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body.
Wu Fangbai +4 more
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PLoS ONE, 2014 We generated C57BL/6NTac mice carrying a tyrosinase loss-of function mutation and a reversion of the nonagouti locus to agouti. This strain has a high superovulation response, allows visual detection of chimeric coat color contribution of C57BL/6 ES ...
Branko Zevnik +5 more
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Outbred mice as an appropriate model for evaluating the immunogenicity of vaccines against porcine circovirus 2 [PDF]
Open Veterinary JournalBackground: Porcine circovirus type 2 (PCV2) is the causative agent of porcine circovirus-associated diseases, leading to substantial economic losses in global swine production.
Vitor Barbosa Fialho Martins +9 more
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Repairing Atp10D in C57Bl/6J mice restores protein expression but does not mitigate metabolic stress from high fat diet [PDF]
Scientific ReportsC57BL/6J mice are widely used in biomedical research and are susceptible to insulin resistance and dyslipidemia when challenged with high fat diets relative to other inbred strains.
Alexander J. Mansueto +13 more
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Scientific ReportsPreclinical models of neurodevelopmental and psychiatric conditions often rely on inbred mouse strains like C57BL/6J (B6), which exhibit limited genetic and behavioral variability.
Ana Dudas +6 more
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Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice [PDF]
Physiology & Behavior, 2013 Human alcoholics display dramatic disruptions of circadian rhythms that may contribute to the maintenance of excessive drinking, thus creating a vicious cycle. While clinical studies cannot establish direct causal mechanisms, recent animal experiments have revealed bidirectional interactions between circadian rhythms and ethanol intake, suggesting that
Alan M, Rosenwasser, Michael C, Fixaris
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OncoImmunology, 2022 Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic ...
Justin B. Hackett +9 more
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