Results 41 to 50 of about 209,389 (213)

Delayed Clinical and Pathological Signs in Twitcher (Globoid Cell Leukodystrophy) Mice on a C57BL/6 × CAST/Ei Background

Neurobiology of Disease, 2002
Modifier genes may account for the phenotypic variability observed in the late-onset forms of globoid cell leukodystrophy (GCL) in humans. In order to begin a search for modifier genes, the effect of genetic background on the clinical and pathological ...
Sangita Biswas, Homigol Biesiada, Todd D. Williams, Steven M. LeVine   +3 more
doaj   +1 more source

Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma. [PDF]

PLoS ONE, 2017
Asthma is a chronic inflammatory disease characterized by bronchial hyperresponsiveness, mucus overproduction and airway remodeling. Notably, we have recently demonstrated that insulin-like growth factor 1 receptor (IGF1R) deficiency in mice attenuates ...
Sergio Piñeiro-Hermida, Elvira Alfaro-Arnedo, Joshua A Gregory, Raquel Torrens, Carlos Ruíz-Martínez, Mikael Adner, Icíar P López, José G Pichel   +7 more
doaj   +1 more source

Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice [PDF]

, 2021
Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet.
Cornejo, María Paula, Valdivia Torres, Lesly Spring, Andreoli, Maria Florencia, Perelló, Mario Carlos, De Francesco, Pablo Nicolás, Barrile, Franco, García Romero, Guadalupe   +6 more
core  

Stimulus Complexity and Mouse Strain Drive Escalation of Operant Sensation Seeking Within and Across Sessions in C57BL/6J and DBA/2J Mice

Frontiers in Behavioral Neuroscience, 2020
Sensation seeking is a heritable trait that is genetically correlated with substance use; the shared genetic mechanisms underlying these traits are largely unknown.
Price E. Dickson, Guy Mittleman
doaj   +1 more source

Genetic and morphometric characteristics of Korean wild mice (KWM/Hym) captured at Chuncheon, South Korea

Laboratory Animal Research, 2018
Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a ...
Hajin Nam, Yoo Yeon Kim, Boyoung Kim, Won Kee Yoon, Hyoung-Chin Kim, Jun Gyo Suh   +5 more
doaj   +1 more source

Differential Effects on Survival, Humoral Immune Responses and Brain Lesions in Inbred BALB/C, CBA/CA, and C57BL/6 Mice Experimentally Infected with Neospora caninum Tachyzoites [PDF]

, 2013
C57BL/6, BALB/c, and CBA/Ca mouse strains with different MHC-I haplotypes were compared with respect to susceptibility to Neospora caninum infection. Groups of 5 mice received , , or tachyzoites of the NC-Liverpool isolate by intraperitoneal injection ...
Monney, Thierry, Mols-Vorstermans, Tanja, Boerhout, Eveline, Andrew Hemphill, Dick Schaap, Schaap, Dick, Hemphill, Andrew, Thierry Monney, Eveline Boerhout, Tanja Mols-Vorstermans   +9 more
core   +1 more source

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

Animal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang, Yan Zan, Tiantian Ma, Xiaoquan Huang, Junwei Li, Liangjun Xia, Yuping Sa, Youbing Xia   +7 more
wiley   +1 more source

Animal research in the UK: Regulation, implementation, welfare and development of new approach methodologies

Animal Models and Experimental Medicine, EarlyView.
Scientific research with animals in the UK is regulated by the Animals (Scientific Procedures) Act 1986 with the National Centre for the Replacement, Refinement and Reduction of Animals in Research providing support for best practice and facilitating development of new approach methodologies.
Ewan St. John Smith, James Bussell, Maggie Gentry, Elliot Lilley, Cathy Merry, Judy MacArthur Clark, William Reynolds   +6 more
wiley   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

High-Resolution Maps of Mouse Reference Populations

G3: Genes, Genomes, Genetics, 2017
Genetic reference panels are widely used to map complex, quantitative traits in model organisms. We have generated new high-resolution genetic maps of 259 mouse inbred strains from recombinant inbred strain panels (C57BL/6J × DBA/2J, ILS/IbgTejJ × ISS ...
Petr Simecek, Jiri Forejt, Robert W. Williams, Toshihiko Shiroishi, Toyoyuki Takada, Lu Lu, Thomas E. Johnson, Beth Bennett, Christian F. Deschepper, Marie-Pier Scott-Boyer, Fernando Pardo-Manuel de Villena, Gary A. Churchill   +11 more
doaj   +1 more source