Results 51 to 60 of about 1,340,693 (219)

High-Resolution Maps of Mouse Reference Populations

G3: Genes, Genomes, Genetics, 2017
Genetic reference panels are widely used to map complex, quantitative traits in model organisms. We have generated new high-resolution genetic maps of 259 mouse inbred strains from recombinant inbred strain panels (C57BL/6J × DBA/2J, ILS/IbgTejJ × ISS ...
Petr Simecek, Jiri Forejt, Robert W. Williams, Toshihiko Shiroishi, Toyoyuki Takada, Lu Lu, Thomas E. Johnson, Beth Bennett, Christian F. Deschepper, Marie-Pier Scott-Boyer, Fernando Pardo-Manuel de Villena, Gary A. Churchill   +11 more
doaj   +1 more source

Baseline podocyte‐associated state and persistent cell–matrix transcriptional programs are associated with BALB/c substrain differences in adriamycin nephropathy

Animal Models and Experimental Medicine, EarlyView.
Two closely related BALB/c substrains exhibit different early responses to adriamycin (ADR)‐induced nephropathy. BALB/cByJcl mice showed lower baseline WT1‐positive nuclei counts and NPHS1 immunoreactivity than BALB/cAJcl mice, together with extracellular matrix and integrin programs that were enriched at baseline and persisted at Day 5.
Ryuya Nakagawa, Masaki Watanabe, Koyuki Kawamoto, Momoka Hiratsuka, Takeru Sasaki, Nobuya Sasaki   +5 more
wiley   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Inbred mouse strains and genetic stability: a review

Animal, 2011
Inbred mice were essential animal models for scientific research during the 20th century and will contribute decisive results in the current and next centuries.
J. Casellas
doaj   +1 more source

Genetic variation in testicular development in mice of the C57BL/10ScSn, C57BL/6By and BALB/cBy strains and the CXB recombinant-inbred lines [PDF]

Reproduction, 1989
Summary. When compared with C57BL/6By mice, BALB/cBy mice had testes that were 41% heavier at 60 days of age and seminiferous tubules that were 41% greater in cross-sectional area at 120 days. Absolute testicular weight did not increase between 60 and 120 days of age in either C57BL/6By or C57BL/10ScSn mice but did in BALB mice, paralleling changes in ...
N M, Shukri, J G, Shire
openaire   +2 more sources

Exclusive enteral nutrition containing transforming growth factor‐β improves intestinal barrier function in a colitis mouse model

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Exclusive enteral nutrition (EEN) is the first‐line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the anti‐inflammatory effects of EEN, studying the nutritional composition and transforming growth factor‐β (TGF‐β) effects, in ...
Kawthar Boumessid, Vickie Lacroix, Ekaterina Ovtchinnikova, Sophie Thenet, Marie Carriere, Frédérick Barreau, Emmanuel Mas   +6 more
wiley   +1 more source

A schematic representation of tularemia pathogenesis in vaccinated inbred C57Bl/6 versus outbred SW Mice.

, 2018
Vaccinated outbred SW and inbred C57BL/6 mice handle the progression and outcome of tularemia disease in different ways. Vaccinated SW mice in comparison to C57BL/6 mice engage early Th1 and Th17 cytokines, along with controlled production of pro ...
Edmund J. Gosselin (212969), Sudeep Kumar (205149), Sarah J. Rosa (6069251), Raju Sunagar (727875), Prachi Namjoshi (5879546), Karsten R. O. Hazlett (212973)   +5 more
core   +1 more source

Immune responses of different mouse strains after challenge with equivalent lethal doses of toxoplasma Gondii

Parasite, 2004
Most immunological studies that utilize different strains of inbred mice following T. gondii infection fail to compensate for differences in host susceptibility to the size of the parasite innoculum.
Lee Y.H., Kasper L.H.
doaj   +1 more source

Geometric morphometrics defines shape differences in the cortical area map of C57BL/6J and DBA/2J inbred mice

BMC Neuroscience, 2006
Background We previously described planar areal differences in adult mouse visual, somatosensory, and neocortex that collectively discriminated C57BL/6J and DBA/2J inbred strain identity.
Guan Monica, Wu Fangbai, Airey David C, Collins Christine E   +3 more
doaj   +1 more source

Quantitative analysis of mouse urine volatiles: in search of MHC-dependent differences. [PDF]

PLoS ONE, 2007
Genes of the major histocompatibility complex (MHC), which play a critical role in immune recognition, influence mating preference and other social behaviors in mice.
Frank Röck, Karl-Peter Hadeler, Hans-Georg Rammensee, Peter Overath   +3 more
doaj   +1 more source