Results 31 to 40 of about 1,340,693 (219)

C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells.

PLoS ONE, 2014
We generated C57BL/6NTac mice carrying a tyrosinase loss-of function mutation and a reversion of the nonagouti locus to agouti. This strain has a high superovulation response, allows visual detection of chimeric coat color contribution of C57BL/6 ES ...
Branko Zevnik, Nathalie C Uyttersprot, Ana V Perez, Gerald W M Bothe, Heidrun Kern, Gunther Kauselmann   +5 more
doaj   +1 more source

Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice [PDF]

, 2012
Although genetic background alters responses to ethanol, there has not yet been a methodical quantification of differences in ethanol-related behaviors between inbred and hybrid mice commonly used in gene-targeting studies. Here, we compared C57BL/6NTac ×
Zou, Mimi E, Messing, Robert O, Robert O. Messing, Mimi E. Zou, Jana P. Lim, Janak, Patricia H, Lim, Jana P, Patricia H. Janak   +7 more
core   +1 more source

Corticotropin-releasing factor receptors couple to multiple g-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning [PDF]

, 2003
Corticotropin-releasing factor (CRF) exerts a key neuroregulatory control on stress responses in various regions of the mammalian brain, including the hippocampus.
Nijholt, I., Thomas Blank, Spiess, Joachim, Blank, Thomas, Spiess, J., Randeva, H., Hillhouse, E., Nijholt, Ingrid, Edward W. Hillhouse, Grammatopoulos, Dimitris K., Grammatopoulos, D. K., Grammatopoulos, D., Joachim Spiess, Blank, T., Randeva, Harpal S., Grammatopoulos, Dimitris, Blank, T. (Thomas), Dimitris K. Grammatopoulos, Hillhouse, Edward W., Randeva, H. S., Harpal S. Randeva, Hillhouse, E. W., Ingrid Nijholt   +22 more
core   +1 more source

Delayed Clinical and Pathological Signs in Twitcher (Globoid Cell Leukodystrophy) Mice on a C57BL/6 × CAST/Ei Background

Neurobiology of Disease, 2002
Modifier genes may account for the phenotypic variability observed in the late-onset forms of globoid cell leukodystrophy (GCL) in humans. In order to begin a search for modifier genes, the effect of genetic background on the clinical and pathological ...
Sangita Biswas, Homigol Biesiada, Todd D. Williams, Steven M. LeVine   +3 more
doaj   +1 more source

Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma. [PDF]

PLoS ONE, 2017
Asthma is a chronic inflammatory disease characterized by bronchial hyperresponsiveness, mucus overproduction and airway remodeling. Notably, we have recently demonstrated that insulin-like growth factor 1 receptor (IGF1R) deficiency in mice attenuates ...
Sergio Piñeiro-Hermida, Elvira Alfaro-Arnedo, Joshua A Gregory, Raquel Torrens, Carlos Ruíz-Martínez, Mikael Adner, Icíar P López, José G Pichel   +7 more
doaj   +1 more source

Stimulus Complexity and Mouse Strain Drive Escalation of Operant Sensation Seeking Within and Across Sessions in C57BL/6J and DBA/2J Mice

Frontiers in Behavioral Neuroscience, 2020
Sensation seeking is a heritable trait that is genetically correlated with substance use; the shared genetic mechanisms underlying these traits are largely unknown.
Price E. Dickson, Guy Mittleman
doaj   +1 more source

Anxiety-related behaviour in C57BL/6?BALB/c chimeric mice. [PDF]

, 2004
In a previous study on anxiety-related behaviours of the genetically and behaviourally distant inbred mouse strains C57BL/6 and BALB/c using the Elevated plus-maze (EPM) and Open-field (OF) apparatuses, we identified a number of variables, the factorial ...
BRUNAMONTI E., MANGIA F., D'OLIMPIO, Francesca, CAROLA V., BEVILACQUA A., RENZI P.   +5 more
core   +2 more sources

Genetic and morphometric characteristics of Korean wild mice (KWM/Hym) captured at Chuncheon, South Korea

Laboratory Animal Research, 2018
Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a ...
Hajin Nam, Yoo Yeon Kim, Boyoung Kim, Won Kee Yoon, Hyoung-Chin Kim, Jun Gyo Suh   +5 more
doaj   +1 more source

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim, Schlöndorff, Detlef   +1 more
core   +1 more source

Compensatory role of C3 convertase on the strain difference for C3 protein expression in FVB/N, C3H/HeN and C57BL/6N mice

Laboratory Animal Research, 2020
To investigate the role of complement C3 (C3) convertase on the strain difference for C3 protein expression in three inbred mice strains, we compared the levels of C2, C3 and C4 mRNA, as well as C3 protein and C3 convertase activity in the serum and ...
Ji Won Park, Ji Eun Kim, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Dae Youn Hwang   +5 more
doaj   +1 more source