Results 1 to 10 of about 13,142 (173)

Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity [PDF]

BMC Neuroscience, 2005
Abstract Background Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regional growth and tissue identity by regulating regional ...
Wu Fangbai, Enzinger Katherine M, Robbins Alicia I, Airey David C, Collins Christine E   +4 more
openaire   +4 more sources

Geometric morphometrics defines shape differences in the cortical area map of C57BL/6J and DBA/2J inbred mice [PDF]

BMC Neuroscience, 2006
We previously described planar areal differences in adult mouse visual, somatosensory, and neocortex that collectively discriminated C57BL/6J and DBA/2J inbred strain identity. Here we use a novel application of established methods of two-dimensional geometric morphometrics to examine shape differences in the cortical area maps of these inbred strains ...
Guan Monica, Wu Fangbai, Airey David C, Collins Christine E   +3 more
openaire   +4 more sources

Genetic variation in the Nr1d1 transcription factor binding site shapes metabolism-related protein networks associated with cognitive resilience in an Alzheimer's disease mouse reference panel. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Our previous work established the AD‐BXD mouse panel as an innovative model for studying the genetic complexity and heterogeneity underlying Alzheimer's disease (AD). In this study, we leveraged this model and proteomics approach to identify protein signatures linked to cognitive resilience in AD.
Chen Y, Stevenson TK, Cao Y, Fish LA, Robbins JE, Merrihew GE, Park J, Hohman TJ, MacCoss MJ, Kaczorowski CC.   +9 more
europepmc   +2 more sources

Efficient Derivation and Transcriptional Characterization of Mouse Extra‐Embryonic Endoderm Stem Cell Lines Generated by Somatic Cell Nuclear Transfer [PDF]

Stem Cells Int
Somatic cell nuclear transfer (SCNT) holds great promise for regenerative medicine and agriculture, but its application is severely hampered by low efficiency, primarily attributable to aberrant epigenetic reprogramming. Although embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) have been successfully derived from cloned embryos, an in ...
Li S, Wei S, Li G, Hu M, Lin J, Bao W.
europepmc   +2 more sources

Susceptibility Analysis in Several Mouse Strains Reveals Robust T-Cell Responses After Mycoplasma pneumoniae Infection in DBA/2 Mice

Frontiers in Cellular and Infection Microbiology, 2021
Mycoplasma pneumoniae (Mp) is a highly contagious respiratory pathogen responsible for human community-acquired pneumonia. The number of antibiotic-resistant Mp strains is increasing; therefore, to develop novel therapeutics, it is crucial to precisely ...
Shigeyuki Tamiya, Shigeyuki Tamiya, Shigeyuki Tamiya, Eisuke Yoshikawa, Eisuke Yoshikawa, Eisuke Yoshikawa, Koichiro Suzuki, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka   +11 more
doaj   +1 more source

Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure. [PDF]

Sci Rep
Drug addiction is a multifactorial syndrome in which genetic predispositions and exposure to environmental stressors constitute major risk factors for the early onset, escalation, and relapse of addictive behaviors.
Morel C, Parise LF, Van der Zee YY, Issler O, Cai M, Browne CJ, Blando A, LeClair KB, Aubry AV, Haynes S, Williams RW, Mulligan MK, Russo SJ, Nestler EJ, Han MH.   +14 more
europepmc   +2 more sources

Behavioral and Metabolome Differences between C57BL/6 and DBA/2 Mouse Strains: Implications for Their Use as Models for Depression- and Anxiety-Like Phenotypes

Metabolites, 2021
Mouse models are widely used to study behavioral phenotypes related to neuropsychiatric disorders. However, different mouse strains vary in their inherent behavioral and molecular characteristics, which needs to be taken into account depending on the ...
Michaela D. Filiou, Markus Nussbaumer, Larysa Teplytska, Christoph W. Turck   +3 more
doaj   +1 more source

Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice [PDF]

Physiology & Behavior, 2013
Human alcoholics display dramatic disruptions of circadian rhythms that may contribute to the maintenance of excessive drinking, thus creating a vicious cycle. While clinical studies cannot establish direct causal mechanisms, recent animal experiments have revealed bidirectional interactions between circadian rhythms and ethanol intake, suggesting that
Alan M, Rosenwasser, Michael C, Fixaris
openaire   +2 more sources

Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases. [PDF]

PLoS ONE, 2012
Mouse embryonic stem (ES) cells are derived from the inner cell mass of blastocyst stage embryos and are used primarily for the creation of genetically engineered strains through gene targeting.
Laura G Reinholdt, Gareth R Howell, Anne M Czechanski, Danilo G Macalinao, Katharine H Macnicoll, Chyuan-Sheng Lin, Leah Rae Donahue, Simon W M John   +7 more
doaj   +1 more source

Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains

mBio, 2022
Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Elaine M. Kohn, Cleison Taira, Hanah Dobson, Lucas Dos Santos Dias, Uju Okaa, Darin L. Wiesner, Marcel Wüthrich, Bruce S. Klein   +7 more
doaj   +1 more source